ENSG00000198911

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361204 ENSG00000198911 HEK293_OSMI2_2hA HEK293_TMG_2hB SREBF2 protein_coding protein_coding 61.52385 80.00165 43.63682 6.383261 0.5836612 -0.8743335 55.41846 76.5795177 37.947617 6.06312664 0.9983927 -1.012758 0.89315417 0.957333333 0.8695 -0.08783333 2.221881e-07 1.473975e-07 FALSE  
ENST00000462539 ENSG00000198911 HEK293_OSMI2_2hA HEK293_TMG_2hB SREBF2 protein_coding retained_intron 61.52385 80.00165 43.63682 6.383261 0.5836612 -0.8743335 2.11539 0.1466934 3.237567 0.07834438 0.6408570 4.373343 0.04035833 0.001666667 0.0745 0.07283333 1.473975e-07 1.473975e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198911 E001 1.1437748 0.0108647759 3.201880e-02 7.589732e-02 22 41833079 41833104 26 + 0.526 0.161 -2.391
ENSG00000198911 E002 2.4034638 0.0062298632 1.034505e-03 4.077823e-03 22 41833105 41833115 11 + 0.791 0.279 -2.529
ENSG00000198911 E003 102.8305802 0.0155474618 2.710474e-10 4.440429e-09 22 41833116 41833163 48 + 2.220 1.806 -1.390
ENSG00000198911 E004 307.5566303 0.0089577122 1.827576e-09 2.578794e-08 22 41833164 41833358 195 + 2.620 2.346 -0.913
ENSG00000198911 E005 728.2998247 0.0012607097 1.322132e-14 4.277219e-13 22 41866831 41867280 450 + 2.914 2.770 -0.479
ENSG00000198911 E006 498.2251641 0.0010245602 8.627955e-11 1.539840e-09 22 41868611 41868792 182 + 2.736 2.611 -0.417
ENSG00000198911 E007 478.4867305 0.0025267865 7.733848e-07 6.581709e-06 22 41870889 41871035 147 + 2.719 2.595 -0.411
ENSG00000198911 E008 1.6596163 0.0083453470 2.293196e-01 3.616257e-01 22 41873689 41873797 109 + 0.526 0.327 -1.070
ENSG00000198911 E009 693.5533703 0.0024699274 1.504019e-07 1.476101e-06 22 41873798 41874019 222 + 2.878 2.757 -0.400
ENSG00000198911 E010 491.6641379 0.0003470867 1.563489e-05 9.936872e-05 22 41875337 41875430 94 + 2.689 2.625 -0.212
ENSG00000198911 E011 352.6163571 0.0008910210 2.853887e-05 1.706253e-04 22 41875431 41875451 21 + 2.559 2.476 -0.277
ENSG00000198911 E012 0.2965864 0.3045940692 6.015273e-01   22 41875452 41875542 91 + 0.001 0.157 8.308
ENSG00000198911 E013 702.6797152 0.0008371097 9.858482e-06 6.563094e-05 22 41875543 41875724 182 + 2.847 2.780 -0.221
ENSG00000198911 E014 665.8206900 0.0001014797 2.906800e-09 3.956351e-08 22 41877229 41877421 193 + 2.824 2.752 -0.239
ENSG00000198911 E015 636.2566846 0.0014027138 2.949845e-03 1.011649e-02 22 41877942 41878123 182 + 2.790 2.742 -0.160
ENSG00000198911 E016 3.7266763 0.0041264344 4.221428e-02 9.511732e-02 22 41878659 41878758 100 + 0.823 0.540 -1.196
ENSG00000198911 E017 711.2705672 0.0031968473 9.647723e-01 9.817914e-01 22 41880716 41880992 277 + 2.791 2.812 0.070
ENSG00000198911 E018 601.9463521 0.0014453709 3.933614e-01 5.372557e-01 22 41884842 41885011 170 + 2.731 2.732 0.004
ENSG00000198911 E019 4.0890293 0.0044448264 6.714911e-03 2.048172e-02 22 41885596 41886164 569 + 0.907 0.540 -1.519
ENSG00000198911 E020 2.5067162 0.0098729212 8.658667e-02 1.699431e-01 22 41886269 41886308 40 + 0.679 0.411 -1.261
ENSG00000198911 E021 3.2314443 0.0054631913 3.354237e-01 4.792090e-01 22 41891250 41891399 150 + 0.679 0.541 -0.609
ENSG00000198911 E022 703.6650742 0.0002114354 7.498124e-01 8.366531e-01 22 41893117 41893285 169 + 2.789 2.802 0.043
ENSG00000198911 E023 599.8355804 0.0004784435 2.778663e-01 4.174912e-01 22 41894820 41894937 118 + 2.701 2.740 0.130
ENSG00000198911 E024 203.4151704 0.0003842901 8.766917e-01 9.248528e-01 22 41897052 41897067 16 + 2.245 2.267 0.073
ENSG00000198911 E025 387.9174349 0.0001626075 2.816694e-02 6.834111e-02 22 41897068 41897161 94 + 2.493 2.556 0.209
ENSG00000198911 E026 284.0425049 0.0001935012 2.022471e-01 3.290234e-01 22 41898649 41898675 27 + 2.372 2.419 0.159
ENSG00000198911 E027 544.6380055 0.0001319888 1.022709e-03 4.037030e-03 22 41898676 41898781 106 + 2.632 2.707 0.249
ENSG00000198911 E028 13.3856325 0.0016571718 4.147721e-02 9.376545e-02 22 41898782 41899188 407 + 1.231 1.054 -0.634
ENSG00000198911 E029 13.0527445 0.0013403421 1.112668e-03 4.346041e-03 22 41899237 41899553 317 + 1.288 0.999 -1.033
ENSG00000198911 E030 6.9860177 0.0093068236 2.413833e-01 3.758019e-01 22 41900020 41900082 63 + 0.955 0.821 -0.513
ENSG00000198911 E031 6.0993911 0.0136707690 3.725570e-01 5.169962e-01 22 41900083 41900122 40 + 0.881 0.775 -0.414
ENSG00000198911 E032 8.5284257 0.0275760539 7.445366e-02 1.506590e-01 22 41900123 41900329 207 + 1.074 0.853 -0.824
ENSG00000198911 E033 725.6699950 0.0001017117 2.855976e-05 1.707340e-04 22 41900330 41900498 169 + 2.752 2.833 0.268
ENSG00000198911 E034 690.3681923 0.0007645694 9.905269e-04 3.926028e-03 22 41902970 41903155 186 + 2.729 2.813 0.282
ENSG00000198911 E035 7.8802310 0.0021166655 4.942021e-01 6.311691e-01 22 41904535 41904732 198 + 0.955 0.889 -0.251
ENSG00000198911 E036 434.4876237 0.0012978862 8.057271e-07 6.826701e-06 22 41904863 41904974 112 + 2.479 2.628 0.494
ENSG00000198911 E037 1786.5728031 0.0024647867 9.299146e-08 9.497010e-07 22 41905440 41906145 706 + 3.093 3.244 0.500
ENSG00000198911 E038 531.2574203 0.0041554136 1.842294e-04 8.959722e-04 22 41906146 41906278 133 + 2.564 2.719 0.516
ENSG00000198911 E039 1649.4533394 0.0042185458 7.104386e-14 2.061110e-12 22 41906279 41907356 1078 + 2.975 3.230 0.850