ENSG00000198909

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361357 ENSG00000198909 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K3 protein_coding protein_coding 26.23517 33.45174 20.0926 1.359586 1.248236 -0.7351303 6.293843 8.977351 5.067022 0.8929344 0.5327822 -0.8239135 0.23762083 0.2677333 0.2518667 -0.01586667 8.763036e-01 2.183861e-24 FALSE TRUE
ENST00000361733 ENSG00000198909 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K3 protein_coding protein_coding 26.23517 33.45174 20.0926 1.359586 1.248236 -0.7351303 9.122827 15.103573 4.314295 1.2323200 0.7671278 -1.8053079 0.32553333 0.4531667 0.2193667 -0.23380000 2.260886e-02 2.183861e-24 FALSE TRUE
ENST00000577395 ENSG00000198909 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K3 protein_coding protein_coding 26.23517 33.45174 20.0926 1.359586 1.248236 -0.7351303 1.570787 0.000000 2.891493 0.0000000 0.5089799 8.1806518 0.07431667 0.0000000 0.1436000 0.14360000 2.183861e-24 2.183861e-24 FALSE TRUE
ENST00000578622 ENSG00000198909 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K3 protein_coding retained_intron 26.23517 33.45174 20.0926 1.359586 1.248236 -0.7351303 1.621174 1.676845 1.804845 0.3948618 0.4872346 0.1055192 0.06483333 0.0499000 0.0878000 0.03790000 3.483091e-01 2.183861e-24 FALSE FALSE
MSTRG.14901.8 ENSG00000198909 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K3 protein_coding   26.23517 33.45174 20.0926 1.359586 1.248236 -0.7351303 2.166602 2.050690 1.965960 0.5954886 0.1200604 -0.0605733 0.08331250 0.0601000 0.0979000 0.03780000 2.946541e-01 2.183861e-24 FALSE TRUE
MSTRG.14901.9 ENSG00000198909 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K3 protein_coding   26.23517 33.45174 20.0926 1.359586 1.248236 -0.7351303 3.071719 4.349510 2.078958 0.5390238 0.8552925 -1.0613824 0.11769583 0.1297333 0.1017667 -0.02796667 7.058812e-01 2.183861e-24 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198909 E001 0.8438776 0.2788365253 7.186192e-01 8.136549e-01 17 63622415 63622416 2 + 0.269 0.242 -0.203
ENSG00000198909 E002 0.8438776 0.2788365253 7.186192e-01 8.136549e-01 17 63622417 63622424 8 + 0.269 0.242 -0.203
ENSG00000198909 E003 2.0982811 0.1555140467 2.057934e-01 3.334117e-01 17 63622425 63622437 13 + 0.603 0.395 -1.022
ENSG00000198909 E004 2.2143090 0.0267896632 8.508121e-02 1.675351e-01 17 63622438 63622441 4 + 0.647 0.394 -1.215
ENSG00000198909 E005 3.7997423 0.1425599979 7.188194e-02 1.464733e-01 17 63622442 63622450 9 + 0.846 0.537 -1.300
ENSG00000198909 E006 5.4132881 0.2219549018 9.952298e-02 1.897578e-01 17 63622451 63622465 15 + 0.962 0.668 -1.161
ENSG00000198909 E007 12.5273399 0.1131618601 2.642669e-05 1.592891e-04 17 63622466 63622595 130 + 1.441 0.755 -2.505
ENSG00000198909 E008 22.5877142 0.0042123673 1.641782e-11 3.300061e-10 17 63622596 63622709 114 + 1.598 1.134 -1.614
ENSG00000198909 E009 16.6499075 0.0090057180 4.666781e-05 2.648853e-04 17 63622710 63622716 7 + 1.406 1.084 -1.134
ENSG00000198909 E010 40.1617983 0.0007855455 3.288515e-09 4.428241e-08 17 63622717 63622763 47 + 1.747 1.472 -0.938
ENSG00000198909 E011 106.4733495 0.0002721033 9.287216e-17 4.016975e-15 17 63632681 63632798 118 + 2.143 1.912 -0.774
ENSG00000198909 E012 72.2168402 0.0017978935 4.750891e-08 5.149571e-07 17 63632799 63632802 4 + 1.955 1.761 -0.656
ENSG00000198909 E013 42.7169292 0.0015499364 2.096042e-04 1.004928e-03 17 63634709 63634801 93 + 1.713 1.560 -0.520
ENSG00000198909 E014 100.1053424 0.0005195361 3.318080e-06 2.460564e-05 17 63646034 63646074 41 + 2.048 1.932 -0.389
ENSG00000198909 E015 135.9323746 0.0003174778 1.289605e-03 4.941381e-03 17 63652557 63652656 100 + 2.135 2.089 -0.155
ENSG00000198909 E016 127.8598693 0.0005263396 1.461226e-03 5.510816e-03 17 63657794 63657907 114 + 2.111 2.061 -0.168
ENSG00000198909 E017 84.2724674 0.0003523620 7.751826e-03 2.315591e-02 17 63666940 63666985 46 + 1.932 1.881 -0.170
ENSG00000198909 E018 99.3790122 0.0006008824 1.731059e-02 4.562509e-02 17 63666986 63667060 75 + 1.995 1.961 -0.114
ENSG00000198909 E019 0.2987644 0.0273651153 7.226372e-02   17 63668146 63668334 189 + 0.269 0.000 -12.269
ENSG00000198909 E020 0.1482932 0.0418576593 1.000000e+00   17 63672845 63672914 70 + 0.000 0.096 9.326
ENSG00000198909 E021 136.8672967 0.0005798009 1.037082e-02 2.967409e-02 17 63681766 63681899 134 + 2.128 2.101 -0.091
ENSG00000198909 E022 110.3480150 0.0014772086 1.462567e-02 3.965238e-02 17 63685517 63685578 62 + 2.043 2.005 -0.126
ENSG00000198909 E023 48.2503833 0.0149568621 4.924612e-01 6.296376e-01 17 63685579 63685590 12 + 1.663 1.667 0.011
ENSG00000198909 E024 20.3911850 0.0030369487 3.224651e-02 7.632535e-02 17 63688199 63688526 328 + 1.383 1.267 -0.404
ENSG00000198909 E025 74.7716989 0.0036013321 1.299547e-01 2.341061e-01 17 63688527 63688528 2 + 1.866 1.848 -0.063
ENSG00000198909 E026 137.2825423 0.0009753190 1.945531e-02 5.032198e-02 17 63688529 63688594 66 + 2.128 2.106 -0.076
ENSG00000198909 E027 0.5848434 0.0205960536 6.427276e-03 1.973338e-02 17 63688742 63688788 47 + 0.434 0.000 -13.403
ENSG00000198909 E028 165.2611122 0.0002494939 1.493976e-03 5.616516e-03 17 63688789 63688881 93 + 2.213 2.177 -0.118
ENSG00000198909 E029 0.9127647 0.0351293032 1.102316e-01 2.058822e-01 17 63689287 63689543 257 + 0.434 0.174 -1.798
ENSG00000198909 E030 232.9314422 0.0001896312 1.475806e-02 3.994556e-02 17 63689544 63689735 192 + 2.340 2.338 -0.009
ENSG00000198909 E031 9.2087330 0.0019954030 1.101799e-01 2.058060e-01 17 63689736 63689997 262 + 1.069 0.949 -0.442
ENSG00000198909 E032 135.5042772 0.0002986683 4.775195e-03 1.530410e-02 17 63690264 63690329 66 + 2.127 2.093 -0.113
ENSG00000198909 E033 165.5422993 0.0002302705 3.237898e-03 1.096687e-02 17 63690330 63690412 83 + 2.211 2.183 -0.093
ENSG00000198909 E034 5.0928032 0.0033446737 1.009355e-03 3.990719e-03 17 63690993 63691101 109 + 0.981 0.598 -1.534
ENSG00000198909 E035 188.4919261 0.0018021922 3.402319e-01 4.841941e-01 17 63691102 63691233 132 + 2.231 2.256 0.083
ENSG00000198909 E036 220.0325464 0.0019934527 3.280631e-01 4.715103e-01 17 63691733 63691862 130 + 2.296 2.321 0.082
ENSG00000198909 E037 231.5877282 0.0007576652 6.709940e-01 7.773410e-01 17 63692242 63692419 178 + 2.287 2.356 0.230
ENSG00000198909 E038 326.6776243 0.0002014689 4.271828e-01 5.700113e-01 17 63693549 63693864 316 + 2.433 2.507 0.248
ENSG00000198909 E039 1040.9318748 0.0035210052 4.617725e-05 2.624233e-04 17 63693865 63695353 1489 + 2.869 3.035 0.553
ENSG00000198909 E040 788.8771161 0.0042948187 2.621134e-20 1.733919e-18 17 63695354 63696305 952 + 2.600 2.954 1.178