ENSG00000198900

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361337 ENSG00000198900 HEK293_OSMI2_2hA HEK293_TMG_2hB TOP1 protein_coding protein_coding 61.82448 36.12074 88.02076 0.7468817 2.619916 1.284781 60.034787 29.388181 87.7499080 2.042717 2.58632401 1.577835 0.95355833 0.8136000 0.9969333 0.1833333 1.870738e-13 1.870738e-13 FALSE TRUE
ENST00000680945 ENSG00000198900 HEK293_OSMI2_2hA HEK293_TMG_2hB TOP1 protein_coding protein_coding 61.82448 36.12074 88.02076 0.7468817 2.619916 1.284781 1.564429 6.671016 0.0861167 1.993573 0.04308639 -6.119137 0.04262917 0.1846667 0.0010000 -0.1836667 2.225312e-10 1.870738e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198900 E001 185.5263949 0.0080261943 1.702990e-08 2.011637e-07 20 41028822 41028913 92 + 2.299 2.030 -0.900
ENSG00000198900 E002 399.4642286 0.0050086747 3.225778e-12 7.283837e-11 20 41028914 41029100 187 + 2.626 2.380 -0.820
ENSG00000198900 E003 215.3033026 0.0072373864 1.345238e-08 1.619029e-07 20 41029431 41029455 25 + 2.360 2.103 -0.857
ENSG00000198900 E004 395.9897028 0.0003083612 1.010925e-28 1.519975e-26 20 41061394 41061490 97 + 2.616 2.404 -0.704
ENSG00000198900 E005 243.0864307 0.0011466157 5.657156e-15 1.932440e-13 20 41076171 41076182 12 + 2.405 2.198 -0.693
ENSG00000198900 E006 435.6153710 0.0002847349 1.104552e-23 1.056305e-21 20 41076183 41076294 112 + 2.649 2.476 -0.576
ENSG00000198900 E007 1.0309706 0.0134150694 6.449650e-02 1.342101e-01 20 41076295 41077581 1287 + 0.373 0.000 -11.451
ENSG00000198900 E008 306.9850370 0.0001566385 1.394720e-11 2.836865e-10 20 41077582 41077637 56 + 2.484 2.364 -0.400
ENSG00000198900 E009 337.1972483 0.0009115590 2.213007e-14 6.919417e-13 20 41080085 41080180 96 + 2.535 2.369 -0.554
ENSG00000198900 E010 299.4661891 0.0006873918 8.081565e-14 2.329268e-12 20 41081165 41081240 76 + 2.483 2.321 -0.543
ENSG00000198900 E011 312.3365948 0.0013089126 1.595210e-08 1.893651e-07 20 41084462 41084568 107 + 2.494 2.368 -0.418
ENSG00000198900 E012 0.1451727 0.0428629456 1.000000e+00   20 41091578 41091699 122 + 0.077 0.000 -8.644
ENSG00000198900 E013 323.0963348 0.0001723943 6.916296e-05 3.759962e-04 20 41092472 41092587 116 + 2.489 2.438 -0.169
ENSG00000198900 E014 3.8481827 0.0039213582 5.476570e-02 1.175873e-01 20 41092588 41095021 2434 + 0.722 0.421 -1.388
ENSG00000198900 E015 3.8317364 0.0461709800 8.823115e-02 1.724240e-01 20 41095022 41096825 1804 + 0.723 0.421 -1.390
ENSG00000198900 E016 0.8868421 0.0331204766 5.272456e-01 6.603667e-01 20 41096826 41097013 188 + 0.295 0.189 -0.839
ENSG00000198900 E017 0.7448917 0.0677796803 1.584723e-01 2.730896e-01 20 41097014 41097219 206 + 0.295 0.000 -10.967
ENSG00000198900 E018 375.6663050 0.0001926879 4.059312e-05 2.335970e-04 20 41097220 41097341 122 + 2.554 2.506 -0.158
ENSG00000198900 E019 328.2162335 0.0006243538 4.396538e-04 1.926786e-03 20 41098215 41098274 60 + 2.495 2.446 -0.162
ENSG00000198900 E020 373.6136565 0.0007156653 1.349646e-03 5.142011e-03 20 41098275 41098337 63 + 2.549 2.510 -0.127
ENSG00000198900 E021 578.6433573 0.0001079841 7.785189e-03 2.324001e-02 20 41100056 41100243 188 + 2.728 2.723 -0.017
ENSG00000198900 E022 532.3656490 0.0006858710 9.582234e-02 1.841194e-01 20 41101209 41101353 145 + 2.689 2.694 0.016
ENSG00000198900 E023 0.9545818 0.0143849649 7.797814e-01 8.584363e-01 20 41104102 41104453 352 + 0.250 0.320 0.487
ENSG00000198900 E024 582.6208444 0.0007837425 3.714965e-02 8.576412e-02 20 41112782 41112925 144 + 2.731 2.727 -0.014
ENSG00000198900 E025 578.0894288 0.0005951456 6.239770e-02 1.306844e-01 20 41113970 41114155 186 + 2.702 2.777 0.249
ENSG00000198900 E026 376.5307473 0.0001664034 2.467578e-08 2.825307e-07 20 41115371 41115439 69 + 2.489 2.638 0.496
ENSG00000198900 E027 486.7513123 0.0003613171 1.001685e-06 8.309234e-06 20 41116278 41116392 115 + 2.607 2.737 0.435
ENSG00000198900 E028 546.0376361 0.0001465199 3.528119e-04 1.591181e-03 20 41118169 41118296 128 + 2.668 2.767 0.328
ENSG00000198900 E029 566.7977080 0.0001117197 1.766567e-02 4.641695e-02 20 41121696 41121790 95 + 2.692 2.770 0.258
ENSG00000198900 E030 315.0801218 0.0001948327 4.489237e-02 1.000064e-01 20 41122006 41122010 5 + 2.437 2.520 0.277
ENSG00000198900 E031 727.6159093 0.0001410313 1.599836e-06 1.271060e-05 20 41122011 41122155 145 + 2.791 2.900 0.362
ENSG00000198900 E032 1964.1248641 0.0029330558 1.922624e-31 3.563947e-29 20 41123195 41124487 1293 + 3.137 3.449 1.037