ENSG00000198887

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361138 ENSG00000198887 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC5 protein_coding protein_coding 14.25613 2.554148 23.59697 0.296497 0.415818 3.202662 7.831003 2.12462025 13.709027 0.27721590 0.6010685 2.684127 0.61691667 0.830900000 0.58076667 -0.25013333 2.925737e-05 2.925737e-05 FALSE TRUE
ENST00000471372 ENSG00000198887 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC5 protein_coding retained_intron 14.25613 2.554148 23.59697 0.296497 0.415818 3.202662 2.809104 0.13419124 3.838601 0.08925986 0.6118847 4.738279 0.17992083 0.062833333 0.16240000 0.09956667 3.026462e-01 2.925737e-05 FALSE TRUE
MSTRG.32851.1 ENSG00000198887 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC5 protein_coding   14.25613 2.554148 23.59697 0.296497 0.415818 3.202662 1.365147 0.10195866 2.387580 0.05834241 0.2170656 4.420541 0.08317083 0.035433333 0.10113333 0.06570000 7.402511e-02 2.925737e-05 FALSE TRUE
MSTRG.32851.5 ENSG00000198887 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC5 protein_coding   14.25613 2.554148 23.59697 0.296497 0.415818 3.202662 0.744000 0.01180594 1.696625 0.01180594 0.8370557 6.290282 0.03368333 0.004533333 0.07196667 0.06743333 6.365146e-02 2.925737e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198887 E001 5.038863 0.0389889031 2.015123e-02 5.180115e-02 9 70258937 70258977 41 + 0.620 0.001 -10.990
ENSG00000198887 E002 22.273047 0.0688842673 1.573159e-01 2.715309e-01 9 70258978 70259012 35 + 1.146 1.013 -0.481
ENSG00000198887 E003 67.943439 0.0196506849 1.301847e-02 3.595466e-02 9 70259013 70259263 251 + 1.610 1.473 -0.468
ENSG00000198887 E004 69.192888 0.0036576710 6.839890e-05 3.724303e-04 9 70264304 70264445 142 + 1.624 1.396 -0.782
ENSG00000198887 E005 51.885084 0.0004725004 3.013081e-04 1.384979e-03 9 70267923 70267975 53 + 1.503 1.283 -0.763
ENSG00000198887 E006 80.094054 0.0003797637 4.700504e-05 2.665917e-04 9 70277310 70277472 163 + 1.684 1.501 -0.623
ENSG00000198887 E007 85.267491 0.0003825043 1.318711e-04 6.670559e-04 9 70278491 70278625 135 + 1.709 1.559 -0.510
ENSG00000198887 E008 92.978535 0.0003224366 1.371738e-04 6.910747e-04 9 70280759 70280899 141 + 1.745 1.610 -0.458
ENSG00000198887 E009 56.703047 0.0005397987 5.672959e-04 2.411211e-03 9 70282422 70282471 50 + 1.539 1.354 -0.637
ENSG00000198887 E010 81.061456 0.0042636662 7.471275e-05 4.028607e-04 9 70282472 70282583 112 + 1.691 1.485 -0.702
ENSG00000198887 E011 1.208409 0.0130298900 8.048111e-01 8.758059e-01 9 70284966 70285039 74 + 0.218 0.330 0.801
ENSG00000198887 E012 67.121576 0.0005738881 5.608640e-05 3.121354e-04 9 70286200 70286271 72 + 1.611 1.396 -0.738
ENSG00000198887 E013 2.280064 0.0067860569 6.661588e-01 7.736543e-01 9 70286746 70286879 134 + 0.345 0.515 0.907
ENSG00000198887 E014 129.142100 0.0009568933 4.300971e-09 5.667428e-08 9 70297966 70298221 256 + 1.893 1.645 -0.836
ENSG00000198887 E015 87.206943 0.0003354011 1.422219e-05 9.117937e-05 9 70300046 70300200 155 + 1.721 1.531 -0.648
ENSG00000198887 E016 60.273020 0.0004325064 1.677775e-02 4.444576e-02 9 70305247 70305360 114 + 1.556 1.485 -0.243
ENSG00000198887 E017 64.254170 0.0003756855 9.358003e-03 2.717713e-02 9 70314742 70314836 95 + 1.583 1.501 -0.281
ENSG00000198887 E018 80.114676 0.0003321918 2.691361e-03 9.348385e-03 9 70315446 70315578 133 + 1.676 1.585 -0.308
ENSG00000198887 E019 94.067442 0.0003540356 6.276152e-02 1.313041e-01 9 70318514 70318687 174 + 1.737 1.745 0.025
ENSG00000198887 E020 99.167397 0.0002902143 3.489256e-03 1.169445e-02 9 70318794 70318963 170 + 1.767 1.707 -0.202
ENSG00000198887 E021 63.553374 0.0045705084 1.918453e-02 4.973795e-02 9 70323483 70323572 90 + 1.581 1.501 -0.274
ENSG00000198887 E022 44.896483 0.0035883844 6.708766e-03 2.046660e-02 9 70323573 70323606 34 + 1.439 1.283 -0.541
ENSG00000198887 E023 67.822628 0.0004088674 9.113853e-02 1.769153e-01 9 70324021 70324143 123 + 1.600 1.598 -0.005
ENSG00000198887 E024 77.260199 0.0027641189 5.611443e-01 6.890199e-01 9 70344144 70344269 126 + 1.646 1.727 0.274
ENSG00000198887 E025 6.924406 0.0029645490 8.281237e-01 8.919970e-01 9 70344270 70344674 405 + 0.683 0.744 0.251
ENSG00000198887 E026 13.703468 0.0054261932 4.670579e-01 6.065737e-01 9 70346392 70346604 213 + 0.951 0.951 0.003
ENSG00000198887 E027 57.320122 0.0008980808 4.463844e-01 5.878857e-01 9 70346605 70346649 45 + 1.523 1.585 0.213
ENSG00000198887 E028 86.702761 0.0002994739 3.603560e-01 5.046731e-01 9 70347066 70347161 96 + 1.697 1.762 0.221
ENSG00000198887 E029 89.721215 0.0002993547 9.743943e-01 9.880166e-01 9 70347613 70347717 105 + 1.706 1.825 0.405
ENSG00000198887 E030 78.507011 0.0003385423 1.307332e-01 2.351775e-01 9 70347919 70348038 120 + 1.636 1.847 0.715
ENSG00000198887 E031 90.544718 0.0002942030 1.192319e-02 3.334975e-02 9 70350114 70350293 180 + 1.689 1.947 0.869
ENSG00000198887 E032 79.428318 0.0006395502 9.241055e-01 9.561962e-01 9 70350376 70350471 96 + 1.651 1.779 0.432
ENSG00000198887 E033 91.333720 0.0105994986 8.044858e-01 8.756330e-01 9 70352191 70352336 146 + 1.712 1.824 0.379
ENSG00000198887 E034 496.584653 0.0122478566 7.378713e-22 5.778731e-20 9 70352337 70354873 2537 + 2.364 2.918 1.845
ENSG00000198887 E035 0.147249 0.0436585744 6.235048e-01   9 70357547 70357712 166 + 0.039 0.001 -5.886