ENSG00000198860

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000423085 ENSG00000198860 HEK293_OSMI2_2hA HEK293_TMG_2hB TSEN15 protein_coding protein_coding 27.92406 19.03751 39.007 1.944802 0.8026948 1.034501 4.042500 3.062859 5.2760081 0.3824148 0.30953392 0.782597 0.1463292 0.1610 0.13570000 -0.0253000 6.097344e-01 8.056789e-18 FALSE TRUE
ENST00000643231 ENSG00000198860 HEK293_OSMI2_2hA HEK293_TMG_2hB TSEN15 protein_coding protein_coding 27.92406 19.03751 39.007 1.944802 0.8026948 1.034501 1.921466 3.623272 0.9202105 0.4185467 0.06743344 -1.965640 0.1101167 0.1924 0.02366667 -0.1687333 8.056789e-18 8.056789e-18 FALSE TRUE
ENST00000645668 ENSG00000198860 HEK293_OSMI2_2hA HEK293_TMG_2hB TSEN15 protein_coding protein_coding 27.92406 19.03751 39.007 1.944802 0.8026948 1.034501 18.315744 9.577723 26.8533438 1.1564794 1.05818201 1.486379 0.6047542 0.5018 0.68790000 0.1861000 4.083709e-07 8.056789e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198860 E001 1.9542307 0.0071747615 3.825693e-02 8.783444e-02 1 184051651 184051675 25 + 0.642 0.227 -2.302
ENSG00000198860 E002 2.4389659 0.0062068041 4.730461e-02 1.043759e-01 1 184051676 184051678 3 + 0.699 0.308 -1.958
ENSG00000198860 E003 2.9141362 0.0050541833 1.504579e-01 2.623065e-01 1 184051679 184051685 7 + 0.725 0.434 -1.329
ENSG00000198860 E004 3.6505056 0.0057516437 4.667988e-01 6.063411e-01 1 184051686 184051698 13 + 0.750 0.574 -0.749
ENSG00000198860 E005 4.3222306 0.0070437214 3.528231e-01 4.970832e-01 1 184051699 184051711 13 + 0.816 0.612 -0.842
ENSG00000198860 E006 7.5535495 0.0022332212 7.907248e-01 8.661688e-01 1 184051712 184051717 6 + 0.984 0.877 -0.402
ENSG00000198860 E007 9.4669160 0.0018364394 6.068594e-01 7.269305e-01 1 184051718 184051721 4 + 1.036 1.012 -0.088
ENSG00000198860 E008 12.2775923 0.0013948628 2.768587e-01 4.163391e-01 1 184051722 184051729 8 + 1.115 1.137 0.081
ENSG00000198860 E009 14.7520578 0.0012358240 5.353062e-01 6.671717e-01 1 184051730 184051732 3 + 1.215 1.188 -0.095
ENSG00000198860 E010 69.6528116 0.0006080420 5.375165e-02 1.158169e-01 1 184051733 184051755 23 + 1.855 1.852 -0.010
ENSG00000198860 E011 107.0479629 0.0042780053 1.772452e-03 6.511512e-03 1 184051756 184051793 38 + 2.007 2.058 0.170
ENSG00000198860 E012 169.3731804 0.0027599079 5.130059e-04 2.208380e-03 1 184051794 184051864 71 + 2.215 2.248 0.111
ENSG00000198860 E013 152.4453596 0.0017928442 8.340188e-06 5.642445e-05 1 184051865 184051890 26 + 2.154 2.216 0.208
ENSG00000198860 E014 125.5271815 0.0008950662 5.135230e-07 4.532280e-06 1 184054354 184054360 7 + 2.060 2.141 0.273
ENSG00000198860 E015 246.9155869 0.0011941301 1.645088e-09 2.342934e-08 1 184054361 184054435 75 + 2.359 2.430 0.236
ENSG00000198860 E016 356.7999081 0.0002019277 2.973385e-13 7.897236e-12 1 184054728 184054863 136 + 2.533 2.580 0.157
ENSG00000198860 E017 1.2396417 0.1653637657 8.669568e-01 9.183902e-01 1 184054864 184055069 206 + 0.404 0.307 -0.582
ENSG00000198860 E018 0.4355181 0.6056176494 3.776035e-01 5.219271e-01 1 184058161 184058240 80 + 0.283 0.000 -10.546
ENSG00000198860 E019 5.5467577 0.0768953851 3.223182e-01 4.656388e-01 1 184070616 184070732 117 + 0.939 0.676 -1.037
ENSG00000198860 E020 4.1612415 0.0037169403 9.319596e-03 2.708136e-02 1 184070733 184071220 488 + 0.891 0.434 -1.980
ENSG00000198860 E021 1.7273837 0.0603632845 8.585522e-01 9.127342e-01 1 184072051 184072156 106 + 0.455 0.433 -0.112
ENSG00000198860 E022 120.8574572 0.0003094355 1.138627e-21 8.736712e-20 1 184072157 184072194 38 + 2.255 1.847 -1.368
ENSG00000198860 E023 145.9160218 0.0002281488 6.261808e-21 4.474843e-19 1 184072195 184072298 104 + 2.323 1.954 -1.236
ENSG00000198860 E024 5.1723005 0.0039602221 7.729765e-02 1.551565e-01 1 184072299 184072310 12 + 0.924 0.612 -1.258
ENSG00000198860 E025 5.2916629 0.0054399684 8.122707e-02 1.614663e-01 1 184072311 184072826 516 + 0.924 0.612 -1.256
ENSG00000198860 E026 851.2422682 0.0192061105 1.008927e-06 8.360520e-06 1 184072827 184074212 1386 + 3.069 2.747 -1.071
ENSG00000198860 E027 10.5372469 0.0017387595 3.769907e-10 6.038704e-09 1 184093625 184093724 100 + 0.642 1.260 2.342
ENSG00000198860 E028 1.6220656 0.0085579918 6.328208e-01 7.476147e-01 1 184093725 184095030 1306 + 0.405 0.434 0.157
ENSG00000198860 E029 4.8845369 0.0032965280 2.678665e-07 2.503774e-06 1 184095031 184095092 62 + 0.284 0.982 3.216
ENSG00000198860 E030 3.0989152 0.3688676461 7.361715e-02 1.493190e-01 1 184095093 184095617 525 + 0.284 0.777 2.437
ENSG00000198860 E031 121.3768059 0.0008372195 3.396286e-93 8.356054e-90 1 184095690 184097485 1796 + 1.604 2.304 2.355
ENSG00000198860 E032 0.3729606 0.0265466715 8.194219e-01 8.859838e-01 1 184112865 184112960 96 + 0.117 0.129 0.160
ENSG00000198860 E033 0.3268771 0.0288145907 8.208349e-01   1 184119042 184119719 678 + 0.117 0.128 0.158
ENSG00000198860 E034 1.1834270 0.0116991376 4.380624e-01 5.799332e-01 1 184119720 184119835 116 + 0.284 0.376 0.573
ENSG00000198860 E035 1.6638958 0.0580569473 6.455509e-01 7.576365e-01 1 184120965 184121250 286 + 0.405 0.435 0.160
ENSG00000198860 E036 2.5099373 0.0060844035 3.992234e-01 5.429682e-01 1 184121787 184122418 632 + 0.499 0.574 0.351
ENSG00000198860 E037 0.5514428 0.0200759313 4.612996e-02 1.022772e-01 1 184122419 184122529 111 + 0.000 0.308 11.130
ENSG00000198860 E038 4.7919704 0.0039119498 2.161347e-02 5.487352e-02 1 184123001 184123978 978 + 0.611 0.857 1.006