ENSG00000198853

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361226 ENSG00000198853 HEK293_OSMI2_2hA HEK293_TMG_2hB RUSC2 protein_coding protein_coding 3.118773 5.065886 1.521473 0.2545553 0.07952201 -1.728739 1.69007226 2.2543660 0.9419760 0.32937147 0.16541067 -1.2501101 0.60880833 0.4421667 0.6155333 0.17336667 0.41255203 0.0479265 FALSE TRUE
ENST00000455600 ENSG00000198853 HEK293_OSMI2_2hA HEK293_TMG_2hB RUSC2 protein_coding protein_coding 3.118773 5.065886 1.521473 0.2545553 0.07952201 -1.728739 0.14286453 0.2131991 0.1700511 0.06693732 0.04436873 -0.3099246 0.05993333 0.0410000 0.1154667 0.07446667 0.19310096 0.0479265 FALSE TRUE
MSTRG.32616.1 ENSG00000198853 HEK293_OSMI2_2hA HEK293_TMG_2hB RUSC2 protein_coding   3.118773 5.065886 1.521473 0.2545553 0.07952201 -1.728739 1.23722685 2.5983210 0.1957354 0.24177047 0.11036739 -3.6642595 0.30404583 0.5168667 0.1218667 -0.39500000 0.04792650 0.0479265 FALSE TRUE
MSTRG.32616.2 ENSG00000198853 HEK293_OSMI2_2hA HEK293_TMG_2hB RUSC2 protein_coding   3.118773 5.065886 1.521473 0.2545553 0.07952201 -1.728739 0.04351852 0.0000000 0.2137108 0.00000000 0.11505184 4.4835631 0.02336667 0.0000000 0.1471000 0.14710000 0.07094346 0.0479265 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198853 E001 6.577770 0.0031746691 0.0176859764 0.046458058 9 35490111 35490172 62 + 1.018 0.711 -1.185
ENSG00000198853 E002 1.761938 0.0095985229 0.6497173714 0.760881299 9 35538632 35538979 348 + 0.442 0.354 -0.485
ENSG00000198853 E003 1.882207 0.0081455035 0.0296059740 0.071183518 9 35538980 35539108 129 + 0.656 0.279 -1.971
ENSG00000198853 E004 116.308771 0.0097268702 0.0008029434 0.003269607 9 35546430 35548535 2106 + 2.100 1.931 -0.565
ENSG00000198853 E005 70.070318 0.0021368734 0.4882728362 0.625866548 9 35555060 35555701 642 + 1.781 1.742 -0.133
ENSG00000198853 E006 38.255555 0.0006355779 0.5500158258 0.679696600 9 35555952 35556137 186 + 1.531 1.487 -0.150
ENSG00000198853 E007 38.430091 0.0088625490 0.3680987359 0.512496335 9 35556308 35556448 141 + 1.560 1.489 -0.243
ENSG00000198853 E008 26.011550 0.0161696880 0.9941878954 1.000000000 9 35557914 35557990 77 + 1.346 1.342 -0.013
ENSG00000198853 E009 42.672006 0.0011340760 0.6473395981 0.759021024 9 35558197 35558371 175 + 1.567 1.534 -0.115
ENSG00000198853 E010 34.966369 0.0008026328 0.2998123570 0.441397114 9 35558462 35558567 106 + 1.400 1.469 0.238
ENSG00000198853 E011 24.903243 0.0008790323 0.0588299937 0.124628645 9 35559226 35559272 47 + 1.180 1.340 0.565
ENSG00000198853 E012 52.209432 0.0158984680 0.0426837904 0.095967483 9 35560029 35560422 394 + 1.491 1.662 0.582
ENSG00000198853 E013 55.175784 0.0155086311 0.0331733121 0.078148977 9 35560423 35560851 429 + 1.515 1.685 0.580
ENSG00000198853 E014 35.467433 0.0134557891 0.2154301486 0.344945699 9 35560960 35561097 138 + 1.379 1.488 0.375
ENSG00000198853 E015 88.281534 0.0090356018 0.1636958083 0.279946918 9 35561181 35561898 718 + 1.790 1.871 0.275