ENSG00000198837

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361217 ENSG00000198837 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND4B protein_coding protein_coding 35.35476 30.57241 31.17017 3.153619 1.560518 0.0279268 5.444244 8.6823451 2.533942 0.70022827 0.7462860 -1.7726800 0.15465417 0.28593333 0.08316667 -0.202766667 2.755732e-03 1.364578e-06 FALSE TRUE
ENST00000464048 ENSG00000198837 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND4B protein_coding retained_intron 35.35476 30.57241 31.17017 3.153619 1.560518 0.0279268 2.565911 0.8542991 2.568152 0.13813647 0.2452577 1.5767346 0.06961250 0.02800000 0.08213333 0.054133333 1.364578e-06 1.364578e-06 FALSE FALSE
ENST00000480340 ENSG00000198837 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND4B protein_coding retained_intron 35.35476 30.57241 31.17017 3.153619 1.560518 0.0279268 3.057901 2.0762497 2.337025 0.05530851 0.1148766 0.1699211 0.08647500 0.06946667 0.07500000 0.005533333 8.613548e-01 1.364578e-06 TRUE FALSE
ENST00000485359 ENSG00000198837 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND4B protein_coding retained_intron 35.35476 30.57241 31.17017 3.153619 1.560518 0.0279268 3.614570 1.3174646 3.991853 0.31858106 0.3966428 1.5919948 0.09970417 0.04170000 0.12753333 0.085833333 5.735414e-06 1.364578e-06 FALSE TRUE
ENST00000492898 ENSG00000198837 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND4B protein_coding retained_intron 35.35476 30.57241 31.17017 3.153619 1.560518 0.0279268 2.386338 1.9812571 1.806533 0.50716077 0.5393840 -0.1324916 0.06591667 0.06556667 0.05960000 -0.005966667 9.138494e-01 1.364578e-06 TRUE TRUE
MSTRG.2258.1 ENSG00000198837 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND4B protein_coding   35.35476 30.57241 31.17017 3.153619 1.560518 0.0279268 7.782213 10.1468798 7.757848 0.93253168 0.9500765 -0.3868704 0.23322500 0.33363333 0.24803333 -0.085600000 1.288150e-01 1.364578e-06 FALSE TRUE
MSTRG.2258.5 ENSG00000198837 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND4B protein_coding   35.35476 30.57241 31.17017 3.153619 1.560518 0.0279268 3.226170 1.0446548 3.524465 0.81441193 0.5594464 1.7447211 0.08946667 0.03380000 0.11253333 0.078733333 3.163486e-01 1.364578e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198837 E001 4.3771754 0.0039933674 3.416607e-03 1.148714e-02 1 153929483 153929500 18 - 0.340 0.821 2.240
ENSG00000198837 E002 317.4238381 0.0077058306 4.706095e-13 1.216477e-11 1 153929501 153929821 321 - 2.217 2.583 1.221
ENSG00000198837 E003 195.9387008 0.0012724662 1.089816e-17 5.328063e-16 1 153929822 153929925 104 - 2.061 2.355 0.980
ENSG00000198837 E004 188.7300589 0.0022394117 5.351431e-07 4.706214e-06 1 153929926 153929985 60 - 2.126 2.316 0.635
ENSG00000198837 E005 179.2337068 0.0027601887 1.011477e-04 5.271850e-04 1 153929986 153930015 30 - 2.129 2.286 0.525
ENSG00000198837 E006 362.7497283 0.0002424203 1.049620e-06 8.670422e-06 1 153930016 153930245 230 - 2.466 2.574 0.359
ENSG00000198837 E007 329.9714321 0.0003161032 1.272375e-04 6.467087e-04 1 153930246 153930442 197 - 2.434 2.525 0.306
ENSG00000198837 E008 211.2525105 0.0002545287 1.403757e-06 1.128719e-05 1 153930539 153930603 65 - 2.213 2.348 0.453
ENSG00000198837 E009 12.4926683 0.0014241481 4.753384e-02 1.047926e-01 1 153930604 153930691 88 - 1.216 1.037 -0.645
ENSG00000198837 E010 155.6929915 0.0037373967 1.420490e-02 3.868879e-02 1 153930692 153930741 50 - 2.098 2.211 0.377
ENSG00000198837 E011 214.3231133 0.0002341573 5.034900e-06 3.581716e-05 1 153930742 153930857 116 - 2.223 2.350 0.426
ENSG00000198837 E012 12.8558376 0.0039385276 7.189153e-07 6.158829e-06 1 153930858 153930946 89 - 1.366 0.900 -1.677
ENSG00000198837 E013 186.8567955 0.0001963978 1.358485e-01 2.422791e-01 1 153930947 153931022 76 - 2.219 2.267 0.161
ENSG00000198837 E014 178.0898048 0.0001983107 3.126099e-01 4.551380e-01 1 153931023 153931064 42 - 2.206 2.242 0.119
ENSG00000198837 E015 6.9980136 0.0083684891 6.463298e-03 1.982758e-02 1 153932176 153932203 28 - 1.053 0.724 -1.263
ENSG00000198837 E016 157.0625091 0.0002486750 1.743297e-01 2.938095e-01 1 153932204 153932255 52 - 2.143 2.191 0.161
ENSG00000198837 E017 289.3141245 0.0002069318 2.705024e-03 9.388786e-03 1 153932256 153932440 185 - 2.387 2.462 0.250
ENSG00000198837 E018 13.5460994 0.0012501459 9.822160e-09 1.213182e-07 1 153932441 153932538 98 - 1.401 0.885 -1.856
ENSG00000198837 E019 12.5617509 0.0014381431 1.613323e-06 1.280754e-05 1 153932539 153932641 103 - 1.343 0.900 -1.596
ENSG00000198837 E020 228.3334596 0.0008606523 6.019300e-02 1.269398e-01 1 153932642 153932777 136 - 2.296 2.357 0.203
ENSG00000198837 E021 10.7402844 0.0015778495 5.428088e-04 2.320224e-03 1 153932778 153932860 83 - 1.237 0.900 -1.226
ENSG00000198837 E022 264.3597342 0.0002256464 5.697911e-02 1.214245e-01 1 153932861 153933030 170 - 2.364 2.416 0.174
ENSG00000198837 E023 10.4866873 0.0031520639 9.964800e-05 5.201839e-04 1 153933031 153933196 166 - 1.247 0.854 -1.437
ENSG00000198837 E024 187.8281391 0.0002324654 1.189382e-01 2.184185e-01 1 153933197 153933319 123 - 2.217 2.267 0.169
ENSG00000198837 E025 299.9466573 0.0005745924 2.270812e-03 8.062191e-03 1 153933483 153933871 389 - 2.398 2.480 0.275
ENSG00000198837 E026 179.7419522 0.0002493532 5.973753e-02 1.261745e-01 1 153934135 153934302 168 - 2.190 2.251 0.204
ENSG00000198837 E027 207.9083402 0.0039436424 3.114380e-01 4.538922e-01 1 153934760 153934964 205 - 2.262 2.315 0.178
ENSG00000198837 E028 9.5253672 0.0146697272 3.861564e-02 8.847779e-02 1 153935833 153936059 227 - 1.136 0.902 -0.862
ENSG00000198837 E029 172.2674184 0.0004850955 3.847645e-01 5.289116e-01 1 153936060 153936188 129 - 2.225 2.208 -0.058
ENSG00000198837 E030 230.9298361 0.0007635730 2.765681e-05 1.658647e-04 1 153936542 153936748 207 - 2.407 2.304 -0.345
ENSG00000198837 E031 221.1185967 0.0001995165 7.861344e-05 4.214347e-04 1 153937488 153937614 127 - 2.378 2.289 -0.299
ENSG00000198837 E032 235.3743402 0.0001765111 1.022294e-03 4.035967e-03 1 153937724 153937863 140 - 2.394 2.323 -0.236
ENSG00000198837 E033 206.7385193 0.0002303968 6.509008e-02 1.351770e-01 1 153938900 153939045 146 - 2.319 2.279 -0.133
ENSG00000198837 E034 0.9943357 0.0127614081 1.912848e-01 3.153435e-01 1 153939588 153939588 1 - 0.413 0.186 -1.568
ENSG00000198837 E035 229.2769188 0.0001820412 2.689756e-04 1.253453e-03 1 153939589 153939804 216 - 2.388 2.308 -0.268
ENSG00000198837 E036 35.0796680 0.0011329620 6.490607e-21 4.629616e-19 1 153939805 153940155 351 - 1.806 1.238 -1.950
ENSG00000198837 E037 167.1431869 0.0008488793 6.989487e-05 3.795286e-04 1 153940156 153940256 101 - 2.271 2.157 -0.379
ENSG00000198837 E038 190.4131103 0.0003102317 2.728747e-10 4.469591e-09 1 153940431 153940606 176 - 2.353 2.192 -0.537
ENSG00000198837 E039 7.5779806 0.0054854100 8.441212e-06 5.703350e-05 1 153940607 153940652 46 - 1.173 0.651 -1.998
ENSG00000198837 E040 4.1849714 0.0109611138 1.241583e-02 3.453748e-02 1 153940895 153940903 9 - 0.889 0.533 -1.484
ENSG00000198837 E041 129.4997086 0.0002504647 2.752562e-05 1.651877e-04 1 153940904 153941048 145 - 2.169 2.044 -0.420
ENSG00000198837 E042 8.6817493 0.0100640274 9.120040e-07 7.636527e-06 1 153941049 153941230 182 - 1.247 0.675 -2.156
ENSG00000198837 E043 56.2495830 0.0004113337 6.538682e-03 2.002512e-02 1 153941231 153941233 3 - 1.806 1.684 -0.414
ENSG00000198837 E044 98.7623330 0.0003832014 1.943528e-05 1.209340e-04 1 153941234 153941289 56 - 2.061 1.913 -0.499
ENSG00000198837 E045 81.8760027 0.0003148403 7.034402e-05 3.817781e-04 1 153941374 153941394 21 - 1.985 1.835 -0.504
ENSG00000198837 E046 94.7895019 0.0002961123 1.072335e-07 1.083355e-06 1 153941395 153941440 46 - 2.070 1.883 -0.629
ENSG00000198837 E047 89.5857996 0.0003310101 1.537418e-05 9.787924e-05 1 153941869 153941928 60 - 2.027 1.871 -0.526
ENSG00000198837 E048 110.4902204 0.0023285175 1.165502e-02 3.271270e-02 1 153941929 153942113 185 - 2.080 1.987 -0.313
ENSG00000198837 E049 3.8479803 0.0042485081 5.411488e-05 3.023000e-04 1 153942114 153942186 73 - 0.951 0.368 -2.570
ENSG00000198837 E050 47.2006162 0.0029864075 5.285411e-01 6.614603e-01 1 153942187 153942278 92 - 1.676 1.648 -0.094
ENSG00000198837 E051 42.6786954 0.0005769028 7.421584e-02 1.502840e-01 1 153942279 153942356 78 - 1.672 1.582 -0.308
ENSG00000198837 E052 15.2496994 0.0011301936 2.331590e-10 3.858764e-09 1 153942357 153942555 199 - 1.459 0.915 -1.944
ENSG00000198837 E053 62.0516747 0.0197415459 3.382892e-01 4.821501e-01 1 153942556 153942625 70 - 1.820 1.755 -0.218
ENSG00000198837 E054 175.6045169 0.0106625594 3.711835e-02 8.569918e-02 1 153942878 153943130 253 - 2.289 2.186 -0.345
ENSG00000198837 E055 172.5410623 0.0015776449 5.192892e-08 5.581347e-07 1 153944058 153944397 340 - 2.316 2.147 -0.565
ENSG00000198837 E056 2.5580111 0.0738374946 2.788994e-01 4.185777e-01 1 153945135 153945283 149 - 0.660 0.457 -0.941
ENSG00000198837 E057 0.8909948 0.0134977672 3.042789e-02 7.280028e-02 1 153945826 153945880 55 - 0.475 0.103 -2.889
ENSG00000198837 E058 17.1106794 0.0012294574 6.932286e-05 3.767571e-04 1 153946297 153946300 4 - 1.408 1.087 -1.130
ENSG00000198837 E059 53.2774890 0.0239060622 8.283050e-05 4.414435e-04 1 153946301 153946882 582 - 1.893 1.564 -1.114