ENSG00000198836

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361510 ENSG00000198836 HEK293_OSMI2_2hA HEK293_TMG_2hB OPA1 protein_coding protein_coding 18.94341 4.022157 29.63889 0.5817581 0.6764488 2.878354 0.6467229 0.0000000 2.0674420 0.0000000 0.2589188 7.698664 0.02858333 0.00000000 0.069400000 0.06940000 1.937356e-07 1.937356e-07 FALSE TRUE
ENST00000361828 ENSG00000198836 HEK293_OSMI2_2hA HEK293_TMG_2hB OPA1 protein_coding protein_coding 18.94341 4.022157 29.63889 0.5817581 0.6764488 2.878354 1.1251513 0.5705840 2.4375831 0.2178362 0.7522300 2.075781 0.09881250 0.16120000 0.081900000 -0.07930000 6.749238e-01 1.937356e-07 FALSE TRUE
ENST00000361908 ENSG00000198836 HEK293_OSMI2_2hA HEK293_TMG_2hB OPA1 protein_coding protein_coding 18.94341 4.022157 29.63889 0.5817581 0.6764488 2.878354 3.4178660 0.9313659 4.4085557 0.1810525 0.6344509 2.230747 0.18797917 0.23023333 0.149866667 -0.08036667 2.644934e-01 1.937356e-07 FALSE TRUE
ENST00000392436 ENSG00000198836 HEK293_OSMI2_2hA HEK293_TMG_2hB OPA1 protein_coding protein_coding 18.94341 4.022157 29.63889 0.5817581 0.6764488 2.878354 4.2481703 0.1505235 7.8015771 0.1196413 0.7320699 5.604757 0.16869583 0.03163333 0.264233333 0.23260000 6.641825e-03 1.937356e-07 FALSE TRUE
ENST00000392437 ENSG00000198836 HEK293_OSMI2_2hA HEK293_TMG_2hB OPA1 protein_coding protein_coding 18.94341 4.022157 29.63889 0.5817581 0.6764488 2.878354 0.6121442 0.2167252 0.1851446 0.2167252 0.1851446 -0.216401 0.03348333 0.06676667 0.006033333 -0.06073333 7.995570e-01 1.937356e-07 FALSE TRUE
ENST00000475899 ENSG00000198836 HEK293_OSMI2_2hA HEK293_TMG_2hB OPA1 protein_coding retained_intron 18.94341 4.022157 29.63889 0.5817581 0.6764488 2.878354 1.7645518 0.0000000 1.8230499 0.0000000 1.0781685 7.518102 0.05505000 0.00000000 0.059933333 0.05993333 4.549371e-01 1.937356e-07 FALSE TRUE
ENST00000482865 ENSG00000198836 HEK293_OSMI2_2hA HEK293_TMG_2hB OPA1 protein_coding retained_intron 18.94341 4.022157 29.63889 0.5817581 0.6764488 2.878354 4.5037626 0.6889073 6.4963322 0.4849397 0.3457566 3.218671 0.22203333 0.14520000 0.219166667 0.07396667 6.658821e-01 1.937356e-07 FALSE FALSE
ENST00000646544 ENSG00000198836 HEK293_OSMI2_2hA HEK293_TMG_2hB OPA1 protein_coding protein_coding 18.94341 4.022157 29.63889 0.5817581 0.6764488 2.878354 0.1988384 0.5612497 0.0000000 0.5612497 0.0000000 -5.836050 0.04818333 0.15333333 0.000000000 -0.15333333 5.111218e-01 1.937356e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198836 E001 4.8539468 0.0417855977 4.780867e-01 6.165351e-01 3 193593144 193593185 42 + 0.660 0.555 -0.462
ENSG00000198836 E002 8.1240812 0.0082777774 5.417428e-01 6.726840e-01 3 193593186 193593207 22 + 0.839 0.790 -0.190
ENSG00000198836 E003 8.5616756 0.0076192618 4.474343e-01 5.888263e-01 3 193593208 193593215 8 + 0.861 0.790 -0.278
ENSG00000198836 E004 8.7111147 0.0022938900 4.091595e-01 5.527754e-01 3 193593216 193593216 1 + 0.869 0.790 -0.305
ENSG00000198836 E005 8.7111147 0.0022938900 4.091595e-01 5.527754e-01 3 193593217 193593217 1 + 0.869 0.790 -0.305
ENSG00000198836 E006 8.8626301 0.0020303297 3.813754e-01 5.256718e-01 3 193593218 193593219 2 + 0.876 0.790 -0.333
ENSG00000198836 E007 8.8626301 0.0020303297 3.813754e-01 5.256718e-01 3 193593220 193593221 2 + 0.876 0.790 -0.333
ENSG00000198836 E008 10.1966316 0.0016518838 1.953871e-01 3.204417e-01 3 193593222 193593227 6 + 0.935 0.790 -0.559
ENSG00000198836 E009 18.1530673 0.0009592997 5.350351e-02 1.153860e-01 3 193593228 193593246 19 + 1.166 0.983 -0.662
ENSG00000198836 E010 23.3967873 0.0007888369 1.740004e-01 2.933798e-01 3 193593247 193593279 33 + 1.257 1.170 -0.309
ENSG00000198836 E011 20.5064087 0.0009063482 1.993650e-01 3.254470e-01 3 193593280 193593280 1 + 1.204 1.116 -0.313
ENSG00000198836 E012 22.2996608 0.0008659835 1.618435e-01 2.775332e-01 3 193593281 193593286 6 + 1.239 1.144 -0.338
ENSG00000198836 E013 22.4490999 0.0008522115 1.528152e-01 2.654780e-01 3 193593287 193593291 5 + 1.242 1.144 -0.349
ENSG00000198836 E014 46.9089046 0.0035128911 2.006675e-02 5.162602e-02 3 193593292 193593409 118 + 1.552 1.415 -0.469
ENSG00000198836 E015 0.2944980 0.4048837871 1.000000e+00   3 193596800 193596946 147 + 0.095 0.000 -11.051
ENSG00000198836 E016 2.0565395 0.0073590653 1.243960e-01 2.262438e-01 3 193603500 193603557 58 + 0.323 0.648 1.641
ENSG00000198836 E017 0.0000000       3 193614722 193614722 1 +      
ENSG00000198836 E018 36.6594369 0.0013033479 6.867287e-04 2.850853e-03 3 193614723 193614761 39 + 1.461 1.195 -0.928
ENSG00000198836 E019 122.5054178 0.0002836271 2.089577e-08 2.427125e-07 3 193614762 193615030 269 + 1.968 1.736 -0.782
ENSG00000198836 E020 48.4949957 0.0007724740 2.381934e-03 8.403954e-03 3 193615031 193615041 11 + 1.570 1.385 -0.634
ENSG00000198836 E021 60.4263674 0.0004090672 1.051960e-04 5.460467e-04 3 193615674 193615702 29 + 1.667 1.443 -0.767
ENSG00000198836 E022 78.7237867 0.0003459899 1.053192e-04 5.465516e-04 3 193615703 193615770 68 + 1.775 1.590 -0.628
ENSG00000198836 E023 86.1598579 0.0003144465 2.619713e-05 1.580714e-04 3 193617178 193617285 108 + 1.814 1.618 -0.662
ENSG00000198836 E024 11.2306711 0.0518102800 4.856949e-02 1.066254e-01 3 193617784 193617837 54 + 0.982 0.653 -1.298
ENSG00000198836 E025 0.3729606 0.0305762672 1.890844e-01 3.125810e-01 3 193618703 193618826 124 + 0.050 0.270 2.813
ENSG00000198836 E026 0.4482035 0.0276482754 1.000000e+00 1.000000e+00 3 193618827 193618868 42 + 0.136 0.000 -11.636
ENSG00000198836 E027 83.7129450 0.0007307819 8.732504e-07 7.344921e-06 3 193618869 193618936 68 + 1.808 1.550 -0.875
ENSG00000198836 E028 0.2966881 0.0269763220 1.000000e+00   3 193618937 193618937 1 + 0.095 0.000 -11.051
ENSG00000198836 E029 0.3729606 0.0305762672 1.890844e-01 3.125810e-01 3 193626058 193626091 34 + 0.050 0.270 2.813
ENSG00000198836 E030 41.9495802 0.0005181732 6.893341e-03 2.094638e-02 3 193626092 193626202 111 + 1.506 1.336 -0.587
ENSG00000198836 E031 1.9971938 0.0070849474 4.855750e-01 6.234504e-01 3 193628509 193628616 108 + 0.393 0.270 -0.774
ENSG00000198836 E032 66.4617597 0.0004283009 5.301918e-06 3.751522e-05 3 193631612 193631665 54 + 1.710 1.443 -0.911
ENSG00000198836 E033 0.5954526 0.0184110722 7.058711e-01 8.041539e-01 3 193631755 193631769 15 + 0.174 0.000 -12.051
ENSG00000198836 E034 75.1745288 0.0010972217 5.373121e-03 1.694333e-02 3 193635418 193635522 105 + 1.747 1.628 -0.404
ENSG00000198836 E035 36.2285173 0.0005704737 2.403846e-01 3.745939e-01 3 193637195 193637215 21 + 1.428 1.385 -0.148
ENSG00000198836 E036 61.1680965 0.0004090663 1.896522e-03 6.903458e-03 3 193637216 193637281 66 + 1.665 1.506 -0.543
ENSG00000198836 E037 73.4771819 0.0011438595 1.169499e-03 4.537333e-03 3 193637952 193638018 67 + 1.744 1.590 -0.521
ENSG00000198836 E038 69.8356928 0.0460123990 9.345809e-02 1.805246e-01 3 193638019 193638065 47 + 1.718 1.597 -0.409
ENSG00000198836 E039 85.9941422 0.0333719820 6.838316e-02 1.406958e-01 3 193642765 193642845 81 + 1.806 1.691 -0.388
ENSG00000198836 E040 82.3718895 0.0314922063 3.216957e-01 4.649467e-01 3 193642975 193643049 75 + 1.775 1.752 -0.077
ENSG00000198836 E041 81.5824936 0.0168181783 2.108980e-01 3.396060e-01 3 193643373 193643444 72 + 1.773 1.735 -0.129
ENSG00000198836 E042 81.1464226 0.0003328732 1.079318e-02 3.066996e-02 3 193643528 193643627 100 + 1.777 1.685 -0.312
ENSG00000198836 E043 0.2903454 0.3200739109 1.000000e+00   3 193643952 193643974 23 + 0.095 0.000 -11.047
ENSG00000198836 E044 93.3675816 0.0003442523 3.671179e-03 1.221429e-02 3 193643975 193644105 131 + 1.839 1.736 -0.346
ENSG00000198836 E045 0.0000000       3 193644106 193644151 46 +      
ENSG00000198836 E046 70.9163051 0.0010285061 1.886294e-02 4.903304e-02 3 193645553 193645611 59 + 1.720 1.627 -0.315
ENSG00000198836 E047 47.2538232 0.0006368914 2.826793e-01 4.227103e-01 3 193645612 193645625 14 + 1.540 1.517 -0.078
ENSG00000198836 E048 71.2949244 0.0007800499 1.559840e-01 2.697733e-01 3 193645728 193645800 73 + 1.715 1.685 -0.101
ENSG00000198836 E049 0.0000000       3 193646485 193646579 95 +      
ENSG00000198836 E050 99.5861349 0.0012196759 3.966390e-01 5.404037e-01 3 193647065 193647180 116 + 1.853 1.866 0.043
ENSG00000198836 E051 80.5592237 0.0003644427 6.797065e-01 7.838061e-01 3 193648070 193648134 65 + 1.750 1.829 0.264
ENSG00000198836 E052 2.9871745 0.0099061181 1.663041e-01 2.833868e-01 3 193648135 193648460 326 + 0.435 0.725 1.326
ENSG00000198836 E053 1.9991814 0.0399032519 4.042953e-01 5.480161e-01 3 193648766 193648794 29 + 0.348 0.554 1.071
ENSG00000198836 E054 90.9259605 0.0008145495 7.571771e-01 8.420799e-01 3 193648795 193648871 77 + 1.804 1.876 0.243
ENSG00000198836 E055 127.1422187 0.0004416733 7.154433e-01 8.113562e-01 3 193654862 193655027 166 + 1.947 2.019 0.242
ENSG00000198836 E056 0.2966881 0.0269763220 1.000000e+00   3 193655028 193655052 25 + 0.095 0.000 -11.051
ENSG00000198836 E057 119.5995550 0.0010807294 1.740385e-01 2.934309e-01 3 193657080 193657232 153 + 1.912 2.030 0.395
ENSG00000198836 E058 102.6610317 0.0003186635 2.047279e-02 5.248605e-02 3 193658887 193658995 109 + 1.839 2.001 0.542
ENSG00000198836 E059 91.1651764 0.0003271470 6.827073e-04 2.835830e-03 3 193659482 193659561 80 + 1.774 1.989 0.727
ENSG00000198836 E060 88.9100137 0.0003543954 1.776599e-01 2.981911e-01 3 193662822 193662890 69 + 1.782 1.905 0.416
ENSG00000198836 E061 104.7488408 0.0002797248 5.360917e-01 6.678498e-01 3 193662891 193662962 72 + 1.860 1.945 0.287
ENSG00000198836 E062 126.5532632 0.0003334390 9.927177e-01 9.995450e-01 3 193664880 193664996 117 + 1.947 2.004 0.191
ENSG00000198836 E063 116.3341282 0.0041510267 1.912983e-01 3.153575e-01 3 193666296 193666389 94 + 1.901 2.025 0.417
ENSG00000198836 E064 69.9278267 0.0031639965 7.244276e-01 8.179456e-01 3 193667170 193667175 6 + 1.692 1.769 0.261
ENSG00000198836 E065 117.1794733 0.0002854861 7.315023e-02 1.485597e-01 3 193667176 193667280 105 + 1.903 2.036 0.447
ENSG00000198836 E066 0.1515154 0.0431140191 9.211835e-01   3 193667371 193667455 85 + 0.050 0.000 -10.052
ENSG00000198836 E067 0.3289534 0.0297480182 1.895338e-01   3 193668315 193668333 19 + 0.050 0.270 2.811
ENSG00000198836 E068 1.4318415 0.0391991229 3.451276e-02 8.073619e-02 3 193668334 193668484 151 + 0.208 0.648 2.488
ENSG00000198836 E069 2.1766288 0.0069149901 7.316226e-06 5.013880e-05 3 193668485 193668931 447 + 0.174 0.942 3.980
ENSG00000198836 E070 0.1817044 0.0394677744 5.895957e-02   3 193689069 193689170 102 + 0.000 0.270 15.397
ENSG00000198836 E071 0.0000000       3 193691394 193692062 669 +      
ENSG00000198836 E072 73.1352067 0.0004014652 1.004576e-05 6.672544e-05 3 193692063 193692132 70 + 1.669 1.949 0.943
ENSG00000198836 E073 508.6162565 0.0213144427 6.769565e-07 5.829956e-06 3 193694606 193697811 3206 + 2.479 2.852 1.241