ENSG00000198830

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361427 ENSG00000198830 HEK293_OSMI2_2hA HEK293_TMG_2hB HMGN2 protein_coding protein_coding 966.3283 1487.525 758.9552 122.5287 28.28286 -0.9708175 912.2712 1455.706 693.2517 122.4625 28.47643 -1.070257 0.934975 0.9783 0.9132 -0.0651 1.694668e-20 4.580667e-25    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198830 E001 3.426849 2.898375e-02 8.315862e-02 1.645119e-01 1 26472332 26472395 64 + 0.359 0.697 1.631
ENSG00000198830 E002 15.796317 8.635077e-03 7.872730e-02 1.574770e-01 1 26472396 26472439 44 + 1.278 1.143 -0.477
ENSG00000198830 E003 17.637653 2.060135e-03 1.661800e-02 4.409534e-02 1 26472440 26472449 10 + 1.342 1.179 -0.572
ENSG00000198830 E004 36.663351 1.056464e-02 8.230364e-01 8.884634e-01 1 26472450 26472462 13 + 1.536 1.552 0.055
ENSG00000198830 E005 68.222282 5.865787e-03 8.331594e-03 2.462203e-02 1 26472463 26472476 14 + 1.670 1.866 0.662
ENSG00000198830 E006 402.128465 1.710748e-04 3.358909e-06 2.487823e-05 1 26472477 26472505 29 + 2.612 2.562 -0.164
ENSG00000198830 E007 463.763487 3.545948e-04 8.873320e-03 2.596376e-02 1 26472506 26472510 5 + 2.648 2.637 -0.039
ENSG00000198830 E008 498.702481 4.503540e-04 6.762496e-02 1.394083e-01 1 26472511 26472514 4 + 2.670 2.673 0.009
ENSG00000198830 E009 550.760071 1.483999e-03 1.494035e-04 7.444321e-04 1 26472515 26472516 2 + 2.752 2.694 -0.193
ENSG00000198830 E010 5636.253031 2.176236e-03 7.102046e-03 2.149299e-02 1 26472517 26472562 46 + 3.741 3.713 -0.092
ENSG00000198830 E011 7469.843319 1.924529e-03 8.599287e-03 2.528612e-02 1 26472563 26472607 45 + 3.859 3.838 -0.070
ENSG00000198830 E012 6344.124794 1.125097e-03 9.695633e-06 6.466953e-05 1 26472608 26472627 20 + 3.799 3.761 -0.127
ENSG00000198830 E013 137.778274 6.065001e-03 8.588913e-50 5.132946e-47 1 26473206 26473428 223 + 2.455 1.744 -2.381
ENSG00000198830 E014 96.963707 4.026586e-04 2.997140e-77 5.793870e-74 1 26473429 26473459 31 + 2.287 1.634 -2.196
ENSG00000198830 E015 109.768759 1.544265e-03 2.561766e-47 1.355640e-44 1 26473460 26473482 23 + 2.295 1.777 -1.738
ENSG00000198830 E016 8266.595805 2.845984e-04 7.730775e-12 1.639875e-10 1 26473483 26473527 45 + 3.905 3.882 -0.078
ENSG00000198830 E017 163.794195 5.436875e-03 1.709746e-44 7.748955e-42 1 26473528 26473585 58 + 2.500 1.885 -2.059
ENSG00000198830 E018 237.372151 7.896532e-03 4.044160e-40 1.408371e-37 1 26473586 26473702 117 + 2.667 2.033 -2.117
ENSG00000198830 E019 8259.082043 3.494251e-05 3.829835e-09 5.095518e-08 1 26473703 26473732 30 + 3.883 3.895 0.038
ENSG00000198830 E020 277.309095 9.478576e-03 6.441562e-32 1.232661e-29 1 26473733 26473817 85 + 2.720 2.125 -1.988
ENSG00000198830 E021 452.096047 4.445877e-03 6.763027e-69 9.855656e-66 1 26473818 26474084 267 + 2.943 2.317 -2.085
ENSG00000198830 E022 9897.316056 8.490943e-05 1.821449e-05 1.140494e-04 1 26474085 26474135 51 + 3.959 3.974 0.049
ENSG00000198830 E023 6227.182994 3.775600e-05 3.546899e-12 7.952064e-11 1 26474572 26474574 3 + 3.767 3.770 0.008
ENSG00000198830 E024 12140.180749 2.509116e-04 3.141878e-02 7.472373e-02 1 26474575 26474667 93 + 4.020 4.073 0.178
ENSG00000198830 E025 155.842772 8.685816e-04 1.469050e-88 3.198932e-85 1 26474668 26475112 445 + 2.474 1.879 -1.992
ENSG00000198830 E026 5555.896727 4.133005e-04 3.796554e-10 6.077791e-09 1 26475113 26475118 6 + 3.644 3.749 0.349
ENSG00000198830 E027 23145.829621 1.356134e-03 1.312014e-24 1.380106e-22 1 26475119 26476642 1524 + 4.201 4.388 0.618