ENSG00000198815

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361346 ENSG00000198815 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXJ3 protein_coding protein_coding 13.73759 8.286475 18.92122 0.9450105 0.4785188 1.190197 7.2197920 1.95388424 10.9745488 1.01297708 0.3021943 2.4836938 0.49453333 0.2408000 0.57996667 0.33916667 0.4534207746 0.0001276573 FALSE TRUE
ENST00000361776 ENSG00000198815 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXJ3 protein_coding protein_coding 13.73759 8.286475 18.92122 0.9450105 0.4785188 1.190197 3.5121337 2.62309727 4.3982265 0.32558935 0.4387988 0.7434375 0.27431250 0.3252333 0.23273333 -0.09250000 0.4668091387 0.0001276573 FALSE TRUE
ENST00000372571 ENSG00000198815 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXJ3 protein_coding protein_coding 13.73759 8.286475 18.92122 0.9450105 0.4785188 1.190197 1.1111400 1.34128665 1.0263874 0.46937984 0.1590586 -0.3827704 0.09187500 0.1551000 0.05396667 -0.10113333 0.0263393060 0.0001276573 FALSE TRUE
ENST00000545068 ENSG00000198815 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXJ3 protein_coding protein_coding 13.73759 8.286475 18.92122 0.9450105 0.4785188 1.190197 0.5171558 1.99740824 0.1344237 1.02060913 0.1344237 -3.7969546 0.05465833 0.2333000 0.00690000 -0.22640000 0.2786164028 0.0001276573 FALSE TRUE
MSTRG.976.10 ENSG00000198815 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXJ3 protein_coding   13.73759 8.286475 18.92122 0.9450105 0.4785188 1.190197 0.8566843 0.04331397 1.6482663 0.04331397 0.0564113 4.9590183 0.05057917 0.0061000 0.08726667 0.08116667 0.0001276573 0.0001276573 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198815 E001 0.9975554 0.3229334448 7.421022e-02 1.502742e-01 1 42176539 42176544 6 - 0.074 0.534 3.705
ENSG00000198815 E002 1.1458486 0.0847756609 1.434498e-02 3.901310e-02 1 42176545 42176547 3 - 0.074 0.591 3.971
ENSG00000198815 E003 1070.5661666 0.0077295749 1.715787e-17 8.160949e-16 1 42176548 42179604 3057 - 2.850 3.210 1.199
ENSG00000198815 E004 142.4579580 0.0025198748 2.160247e-02 5.485551e-02 1 42179605 42179825 221 - 2.091 2.161 0.234
ENSG00000198815 E005 102.1354362 0.0003667507 1.103754e-05 7.261276e-05 1 42181917 42182024 108 - 1.971 1.964 -0.022
ENSG00000198815 E006 115.1838226 0.0028351588 2.955560e-04 1.361844e-03 1 42188737 42188928 192 - 2.019 2.018 -0.002
ENSG00000198815 E007 1.3975885 0.0443517442 1.692849e-01 2.872519e-01 1 42188929 42189302 374 - 0.394 0.197 -1.363
ENSG00000198815 E008 64.5088467 0.0080704330 4.209312e-02 9.490187e-02 1 42189303 42189404 102 - 1.764 1.787 0.076
ENSG00000198815 E009 12.2299312 0.0030062437 1.681792e-05 1.061044e-04 1 42189405 42189809 405 - 1.156 0.789 -1.369
ENSG00000198815 E010 65.2827937 0.0005795052 1.133604e-02 3.196800e-02 1 42191303 42191405 103 - 1.766 1.806 0.136
ENSG00000198815 E011 119.7708526 0.0002849027 9.644323e-06 6.436053e-05 1 42191406 42191719 314 - 2.036 2.043 0.024
ENSG00000198815 E012 82.9110759 0.0003445404 1.517626e-08 1.809375e-07 1 42194890 42194996 107 - 1.902 1.818 -0.283
ENSG00000198815 E013 74.6854592 0.0097409535 2.104378e-02 5.368400e-02 1 42194997 42195064 68 - 1.833 1.838 0.017
ENSG00000198815 E014 87.0533899 0.0003546671 5.231148e-07 4.608777e-06 1 42199102 42199230 129 - 1.916 1.868 -0.162
ENSG00000198815 E015 56.9215641 0.0004528526 1.247308e-08 1.511422e-07 1 42205762 42205863 102 - 1.756 1.614 -0.483
ENSG00000198815 E016 0.1451727 0.0435410841 1.000000e+00   1 42205864 42206011 148 - 0.074 0.000 -10.582
ENSG00000198815 E017 65.1916033 0.0003727908 1.329473e-08 1.601476e-07 1 42227883 42227966 84 - 1.806 1.686 -0.407
ENSG00000198815 E018 0.4847352 0.2692936499 9.177292e-01 9.520059e-01 1 42264931 42265114 184 - 0.137 0.197 0.631
ENSG00000198815 E019 51.6506080 0.0004267249 2.548568e-07 2.393390e-06 1 42265115 42265189 75 - 1.708 1.582 -0.428
ENSG00000198815 E020 107.8213412 0.0042577413 1.540810e-12 3.660670e-11 1 42278348 42278672 325 - 2.039 1.833 -0.690
ENSG00000198815 E021 6.9190191 0.0026540671 1.300944e-02 3.593288e-02 1 42278673 42278784 112 - 0.905 0.700 -0.809
ENSG00000198815 E022 36.8767982 0.0429836482 4.961359e-03 1.582294e-02 1 42311050 42311110 61 - 1.578 1.377 -0.694
ENSG00000198815 E023 0.1515154 0.0437768072 1.000000e+00   1 42315346 42315455 110 - 0.074 0.000 -10.583
ENSG00000198815 E024 0.1515154 0.0437768072 1.000000e+00   1 42315456 42315459 4 - 0.074 0.000 -10.583
ENSG00000198815 E025 1.3683431 0.0096765512 1.467212e-01 2.572216e-01 1 42323684 42323827 144 - 0.394 0.197 -1.368
ENSG00000198815 E026 0.0000000       1 42334925 42334965 41 -      
ENSG00000198815 E027 33.6173802 0.0252094241 2.789383e-05 1.671116e-04 1 42335059 42335235 177 - 1.559 1.249 -1.072
ENSG00000198815 E028 0.6652806 0.0174971708 8.218088e-02 1.629486e-01 1 42335626 42335877 252 - 0.074 0.434 3.215