ENSG00000198805

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361505 ENSG00000198805 HEK293_OSMI2_2hA HEK293_TMG_2hB PNP protein_coding protein_coding 102.9789 125.7342 103.8369 27.60102 1.761824 -0.2760341 93.52154 120.8462 93.58668 26.30434 0.6722842 -0.368762 0.9005792 0.962 0.9016333 -0.06036667 5.405719e-06 3.839008e-12 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198805 E001 0.000000       14 20468954 20469030 77 +      
ENSG00000198805 E002 0.000000       14 20469031 20469031 1 +      
ENSG00000198805 E003 5.365682 6.922695e-03 7.476789e-02 1.511611e-01 14 20469327 20469405 79 + 0.919 0.710 -0.822
ENSG00000198805 E004 7.433206 3.278991e-02 1.422652e-01 2.511248e-01 14 20469406 20469413 8 + 1.025 0.846 -0.674
ENSG00000198805 E005 595.693173 1.277571e-04 1.696079e-12 4.002455e-11 14 20469414 20469535 122 + 2.819 2.743 -0.252
ENSG00000198805 E006 2.624733 5.813086e-03 2.910964e-01 4.319320e-01 14 20469541 20469775 235 + 0.649 0.506 -0.650
ENSG00000198805 E007 2.615372 5.837281e-03 1.262663e-02 3.502975e-02 14 20470526 20470669 144 + 0.749 0.376 -1.741
ENSG00000198805 E008 990.288080 2.158024e-04 8.945966e-07 7.505033e-06 14 20472308 20472477 170 + 3.014 2.979 -0.117
ENSG00000198805 E009 26.993267 7.516628e-04 7.431885e-10 1.129521e-08 14 20472478 20473200 723 + 1.636 1.257 -1.306
ENSG00000198805 E010 43.954979 2.057793e-03 1.235438e-09 1.798310e-08 14 20473384 20474471 1088 + 1.814 1.499 -1.071
ENSG00000198805 E011 796.777942 1.406181e-04 3.617104e-02 8.391657e-02 14 20474472 20474575 104 + 2.899 2.898 -0.002
ENSG00000198805 E012 34.065710 1.650693e-03 4.187126e-04 1.846045e-03 14 20474576 20474772 197 + 1.647 1.459 -0.644
ENSG00000198805 E013 997.699930 7.018556e-04 7.248530e-01 8.182634e-01 14 20474773 20474948 176 + 2.977 3.001 0.078
ENSG00000198805 E014 23.443406 7.540715e-03 1.013947e-04 5.282982e-04 14 20474949 20475061 113 + 1.541 1.254 -0.994
ENSG00000198805 E015 1093.977229 7.955068e-05 7.279973e-03 2.195150e-02 14 20475062 20475252 191 + 3.001 3.058 0.187
ENSG00000198805 E016 9.205544 7.456537e-03 2.855481e-02 6.912318e-02 14 20475994 20476383 390 + 0.805 1.089 1.068
ENSG00000198805 E017 2191.425784 1.630278e-03 7.841387e-06 5.337096e-05 14 20476384 20477089 706 + 3.274 3.359 0.283