ENSG00000198794

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000425597 ENSG00000198794 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAMP5 protein_coding protein_coding 12.67405 19.29962 10.90751 1.139936 0.4216839 -0.8226756 2.6290325 3.1570886 2.907990 0.4920476 0.1232912 -0.1181823 0.2115958 0.1635333 0.26660000 0.103066667 0.031092795 0.003838292 FALSE TRUE
ENST00000562765 ENSG00000198794 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAMP5 protein_coding nonsense_mediated_decay 12.67405 19.29962 10.90751 1.139936 0.4216839 -0.8226756 7.6035184 13.8808585 5.568743 0.6963728 0.1964512 -1.3161237 0.5873500 0.7215000 0.51290000 -0.208600000 0.003838292 0.003838292 FALSE TRUE
ENST00000568081 ENSG00000198794 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAMP5 protein_coding protein_coding 12.67405 19.29962 10.90751 1.139936 0.4216839 -0.8226756 0.8580277 0.8841688 0.478249 0.3613830 0.1216404 -0.8729299 0.0678875 0.0453000 0.04393333 -0.001366667 0.995390754 0.003838292 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198794 E001 4.2038186 0.0037750165 5.567662e-01 6.853473e-01 15 74954429 74957218 2790 + 0.598 0.741 0.607
ENSG00000198794 E002 1.1749062 0.0107210592 2.517199e-01 3.879894e-01 15 74957219 74957467 249 + 0.153 0.398 1.829
ENSG00000198794 E003 0.0000000       15 74995334 74995383 50 +      
ENSG00000198794 E004 0.0000000       15 74995542 74995555 14 +      
ENSG00000198794 E005 0.1472490 0.0424508857 2.494331e-01   15 74995556 74995562 7 + 0.153 0.000 -12.466
ENSG00000198794 E006 0.4439371 0.0215556524 2.086613e-02 5.330329e-02 15 74995563 74995563 1 + 0.356 0.000 -14.247
ENSG00000198794 E007 1.4091281 0.0095407006 7.283654e-03 2.196086e-02 15 74995564 74995569 6 + 0.598 0.176 -2.563
ENSG00000198794 E008 3.6589090 0.0044337427 1.175186e-01 2.163989e-01 15 74995570 74995572 3 + 0.752 0.575 -0.755
ENSG00000198794 E009 10.0887660 0.0544599092 2.147820e-02 5.460107e-02 15 74995573 74995583 11 + 1.174 0.900 -1.006
ENSG00000198794 E010 13.2147653 0.0451845006 3.140147e-02 7.468780e-02 15 74995584 74995597 14 + 1.253 1.033 -0.788
ENSG00000198794 E011 36.1327099 0.0345576992 3.531553e-02 8.225783e-02 15 74995598 74995673 76 + 1.628 1.485 -0.488
ENSG00000198794 E012 0.0000000       15 74995967 74996019 53 +      
ENSG00000198794 E013 0.0000000       15 74996020 74996022 3 +      
ENSG00000198794 E014 0.1451727 0.0426133548 2.495017e-01   15 74996023 74996259 237 + 0.153 0.000 -12.464
ENSG00000198794 E015 0.0000000       15 74996260 74996320 61 +      
ENSG00000198794 E016 0.0000000       15 74997234 74997316 83 +      
ENSG00000198794 E017 0.8354585 0.6912834385 7.851935e-01 8.622986e-01 15 75007588 75007660 73 + 0.265 0.246 -0.144
ENSG00000198794 E018 4.1473163 0.0050091433 2.871164e-01 4.275971e-01 15 75007661 75007728 68 + 0.752 0.654 -0.407
ENSG00000198794 E019 2.2025540 0.0551416430 2.505359e-01 3.865749e-01 15 75009891 75009940 50 + 0.597 0.438 -0.764
ENSG00000198794 E020 0.1482932 0.0414599111 1.000000e+00   15 75011658 75011680 23 + 0.000 0.097 10.924
ENSG00000198794 E021 34.3358770 0.0149433300 1.385618e-02 3.789919e-02 15 75011792 75011806 15 + 1.601 1.468 -0.454
ENSG00000198794 E022 47.3730896 0.0142552224 8.438450e-03 2.488150e-02 15 75011807 75011846 40 + 1.735 1.606 -0.437
ENSG00000198794 E023 93.1331607 0.0003644193 2.295825e-04 1.090232e-03 15 75012677 75012805 129 + 1.987 1.918 -0.232
ENSG00000198794 E024 3.4612875 0.0059325427 2.341653e-04 1.109159e-03 15 75012806 75013124 319 + 0.890 0.399 -2.170
ENSG00000198794 E025 30.8816032 0.0027674646 1.514161e-05 9.655432e-05 15 75016593 75016749 157 + 1.605 1.386 -0.752
ENSG00000198794 E026 3.3600297 0.0177563070 8.879829e-01 9.324064e-01 15 75017653 75017796 144 + 0.598 0.629 0.137
ENSG00000198794 E027 5.2703614 0.0034718198 9.781069e-01 9.904482e-01 15 75017797 75017869 73 + 0.718 0.779 0.247
ENSG00000198794 E028 103.6308210 0.0002910908 2.672169e-03 9.289139e-03 15 75017870 75017971 102 + 2.016 1.979 -0.125
ENSG00000198794 E029 1.3370057 0.0164833579 3.477527e-01 4.919517e-01 15 75018394 75018417 24 + 0.430 0.302 -0.755
ENSG00000198794 E030 104.0832898 0.0003076936 2.769498e-03 9.581670e-03 15 75018418 75018535 118 + 2.018 1.981 -0.124
ENSG00000198794 E031 0.1451727 0.0426133548 2.495017e-01   15 75018536 75018537 2 + 0.153 0.000 -12.464
ENSG00000198794 E032 1083.6899807 0.0033906304 6.780331e-13 1.710632e-11 15 75018789 75021495 2707 + 2.894 3.054 0.532