ENSG00000198791

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361272 ENSG00000198791 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT7 protein_coding protein_coding 51.59719 25.10773 78.94181 2.212547 2.972969 1.652266 3.311096 1.721665 6.415217 0.3753558 0.2626158 1.89158518 0.06133750 0.06710000 0.08123333 0.01413333 0.604919459 0.000261281 FALSE  
ENST00000519918 ENSG00000198791 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT7 protein_coding protein_coding 51.59719 25.10773 78.94181 2.212547 2.972969 1.652266 2.190811 1.640049 1.750796 0.5491518 0.2097067 0.09371964 0.05082917 0.06653333 0.02216667 -0.04436667 0.102949402 0.000261281 FALSE  
ENST00000523917 ENSG00000198791 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT7 protein_coding protein_coding 51.59719 25.10773 78.94181 2.212547 2.972969 1.652266 6.581257 1.823391 10.911322 0.2072165 0.8219300 2.57456080 0.11315000 0.07310000 0.13790000 0.06480000 0.000261281 0.000261281 FALSE  
ENST00000628418 ENSG00000198791 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT7 protein_coding protein_coding 51.59719 25.10773 78.94181 2.212547 2.972969 1.652266 9.461241 5.586422 11.312543 0.1717785 0.2744466 1.01662146 0.20194583 0.22600000 0.14363333 -0.08236667 0.015409591 0.000261281    
MSTRG.31207.2 ENSG00000198791 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT7 protein_coding   51.59719 25.10773 78.94181 2.212547 2.972969 1.652266 28.073278 13.366919 44.844965 2.0156395 1.5931739 1.74552181 0.53143333 0.52693333 0.56820000 0.04126667 0.653262932 0.000261281 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198791 E001 412.4732396 0.0015963627 5.183594e-04 2.228715e-03 8 17224966 17229812 4847 - 2.612 2.520 -0.308
ENSG00000198791 E002 579.0981538 0.0002229918 3.415525e-11 6.514254e-10 8 17229813 17230567 755 - 2.766 2.650 -0.386
ENSG00000198791 E003 420.0365941 0.0001246727 1.900924e-05 1.185049e-04 8 17230568 17230848 281 - 2.571 2.645 0.247
ENSG00000198791 E004 92.3244094 0.0005109818 1.145018e-15 4.288655e-14 8 17231570 17232328 759 - 2.022 1.637 -1.301
ENSG00000198791 E005 34.3145745 0.0009045149 2.623441e-08 2.988953e-07 8 17232329 17232426 98 - 1.610 1.174 -1.511
ENSG00000198791 E006 414.5964759 0.0001427495 1.685405e-05 1.063005e-04 8 17232427 17232537 111 - 2.564 2.639 0.252
ENSG00000198791 E007 4.3984029 0.0037099648 1.578269e-01 2.722299e-01 8 17234593 17234715 123 - 0.639 0.838 0.811
ENSG00000198791 E008 327.2937337 0.0002050649 4.285528e-05 2.453330e-04 8 17234716 17234800 85 - 2.459 2.542 0.276
ENSG00000198791 E009 299.4406716 0.0001826129 4.613407e-03 1.485681e-02 8 17234801 17234860 60 - 2.429 2.488 0.196
ENSG00000198791 E010 239.0410570 0.0002868759 1.555906e-02 4.175484e-02 8 17237212 17237241 30 - 2.331 2.388 0.188
ENSG00000198791 E011 388.8771206 0.0001758268 9.713096e-02 1.860903e-01 8 17237242 17237373 132 - 2.551 2.579 0.093
ENSG00000198791 E012 0.8857980 0.0136968632 1.136540e-01 2.108503e-01 8 17237374 17237595 222 - 0.340 0.000 -10.982
ENSG00000198791 E013 11.8031846 0.0022615324 2.227067e-01 3.536053e-01 8 17241294 17242991 1698 - 1.037 1.158 0.439
ENSG00000198791 E014 157.1802371 0.0002864663 2.086625e-01 3.369027e-01 8 17242992 17242993 2 - 2.156 2.191 0.117
ENSG00000198791 E015 411.9548474 0.0002111975 5.642444e-01 6.915599e-01 8 17242994 17243180 187 - 2.590 2.575 -0.051
ENSG00000198791 E016 154.9313774 0.0010883637 2.511980e-01 3.873661e-01 8 17243181 17243185 5 - 2.177 2.134 -0.145
ENSG00000198791 E017 2.7886214 0.0539205543 2.633735e-02 6.462370e-02 8 17243442 17243506 65 - 0.658 0.186 -2.732
ENSG00000198791 E018 2.2509188 0.0063708545 2.117280e-01 3.405202e-01 8 17243507 17243545 39 - 0.552 0.316 -1.261
ENSG00000198791 E019 2.9077684 0.0060112136 2.608334e-01 3.984097e-01 8 17243546 17243622 77 - 0.619 0.416 -0.975
ENSG00000198791 E020 2.0316491 0.0072139569 3.342467e-01 4.779851e-01 8 17244327 17244541 215 - 0.502 0.317 -1.019
ENSG00000198791 E021 2.9750702 0.0329210988 2.954598e-01 4.365862e-01 8 17244740 17245035 296 - 0.620 0.417 -0.973
ENSG00000198791 E022 343.6236417 0.0008153110 5.563558e-01 6.850238e-01 8 17245036 17245247 212 - 2.513 2.492 -0.070
ENSG00000198791 E023 3.8992726 0.0411547271 6.303130e-01 7.454888e-01 8 17245857 17245931 75 - 0.640 0.721 0.343
ENSG00000198791 E024 0.8899480 0.0282729712 1.262979e-01 2.289971e-01 8 17245932 17245969 38 - 0.145 0.417 2.028
ENSG00000198791 E025 4.4778871 0.0035979447 9.272541e-01 9.582277e-01 8 17246173 17246522 350 - 0.712 0.723 0.047
ENSG00000198791 E026 0.4418608 0.0249936624 4.069778e-01 5.506094e-01 8 17246523 17246674 152 - 0.202 0.000 -9.922
ENSG00000198791 E027 122.3700414 0.0003777169 5.530204e-01 6.822436e-01 8 17246675 17246878 204 - 2.055 2.071 0.055