ENSG00000198756

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361927 ENSG00000198756 HEK293_OSMI2_2hA HEK293_TMG_2hB COLGALT2 protein_coding protein_coding 3.788642 3.070196 3.340297 0.2647668 0.1595156 0.1212668 0.77445483 0.47676269 0.80574896 0.04044072 0.16759864 0.7449066 0.20474167 0.15746667 0.24656667 0.08910000 0.544377954 0.004673683 FALSE TRUE
ENST00000367520 ENSG00000198756 HEK293_OSMI2_2hA HEK293_TMG_2hB COLGALT2 protein_coding protein_coding 3.788642 3.070196 3.340297 0.2647668 0.1595156 0.1212668 0.31864380 0.04354706 0.28958851 0.02386155 0.00793083 2.4841032 0.07994167 0.01310000 0.08686667 0.07376667 0.004673683 0.004673683 FALSE TRUE
ENST00000486375 ENSG00000198756 HEK293_OSMI2_2hA HEK293_TMG_2hB COLGALT2 protein_coding processed_transcript 3.788642 3.070196 3.340297 0.2647668 0.1595156 0.1212668 0.13813799 0.24128316 0.06358915 0.21060119 0.03053840 -1.7717489 0.03896667 0.07406667 0.01833333 -0.05573333 0.792856729 0.004673683   FALSE
MSTRG.2732.4 ENSG00000198756 HEK293_OSMI2_2hA HEK293_TMG_2hB COLGALT2 protein_coding   3.788642 3.070196 3.340297 0.2647668 0.1595156 0.1212668 2.34302242 2.30860283 1.60328886 0.25959520 0.13861415 -0.5232509 0.61891667 0.75546667 0.47850000 -0.27696667 0.024260266 0.004673683 FALSE TRUE
MSTRG.2732.6 ENSG00000198756 HEK293_OSMI2_2hA HEK293_TMG_2hB COLGALT2 protein_coding   3.788642 3.070196 3.340297 0.2647668 0.1595156 0.1212668 0.10866118 0.00000000 0.27310943 0.00000000 0.14117054 4.8232879 0.02919583 0.00000000 0.08536667 0.08536667 0.214597329 0.004673683 FALSE TRUE
MSTRG.2732.8 ENSG00000198756 HEK293_OSMI2_2hA HEK293_TMG_2hB COLGALT2 protein_coding   3.788642 3.070196 3.340297 0.2647668 0.1595156 0.1212668 0.05213227 0.00000000 0.27988330 0.00000000 0.27988330 4.8574003 0.01478750 0.00000000 0.07680000 0.07680000 0.833307774 0.004673683 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198756 E001 0.0000000       1 183929854 183929888 35 -      
ENSG00000198756 E002 0.1515154 0.0433420949 4.804906e-01   1 183929889 183930289 401 - 0.113 0.000 -9.601
ENSG00000198756 E003 1.4642961 0.3055846772 5.901872e-01 7.131052e-01 1 183935178 183935833 656 - 0.441 0.322 -0.685
ENSG00000198756 E004 0.4407149 0.0214289198 5.523260e-01 6.816088e-01 1 183935834 183935836 3 - 0.202 0.133 -0.726
ENSG00000198756 E005 205.4299164 0.0121947599 7.147057e-10 1.090519e-08 1 183935837 183937964 2128 - 2.113 2.455 1.142
ENSG00000198756 E006 35.8640347 0.0230321954 3.495705e-01 4.937859e-01 1 183937965 183938433 469 - 1.468 1.641 0.592
ENSG00000198756 E007 66.8192378 0.0068237803 3.024062e-01 4.442768e-01 1 183938434 183939037 604 - 1.812 1.849 0.125
ENSG00000198756 E008 33.0036932 0.0006466518 4.909971e-02 1.075476e-01 1 183940581 183940787 207 - 1.544 1.521 -0.078
ENSG00000198756 E009 21.4869276 0.0082048161 6.258079e-03 1.928976e-02 1 183944196 183944323 128 - 1.412 1.277 -0.469
ENSG00000198756 E010 20.7874659 0.0049508667 2.804528e-03 9.688709e-03 1 183945432 183945564 133 - 1.402 1.252 -0.523
ENSG00000198756 E011 0.4439371 0.0215876096 8.056769e-02 1.604451e-01 1 183945565 183946618 1054 - 0.276 0.000 -13.444
ENSG00000198756 E012 21.2195568 0.0011829804 1.984072e-02 5.115011e-02 1 183951007 183951113 107 - 1.381 1.301 -0.281
ENSG00000198756 E013 18.9528477 0.0050831594 3.619030e-02 8.394832e-02 1 183954762 183954838 77 - 1.336 1.252 -0.295
ENSG00000198756 E014 19.3469154 0.0010729492 3.820947e-03 1.263893e-02 1 183963901 183964020 120 - 1.365 1.234 -0.460
ENSG00000198756 E015 3.0968847 0.0053754307 1.623566e-01 2.782041e-01 1 183964021 183964500 480 - 0.685 0.545 -0.618
ENSG00000198756 E016 20.8135121 0.0082118369 1.472658e-02 3.987474e-02 1 183969269 183969473 205 - 1.387 1.270 -0.407
ENSG00000198756 E017 15.3825112 0.0017740085 7.823345e-03 2.333736e-02 1 183973616 183973750 135 - 1.280 1.143 -0.485
ENSG00000198756 E018 15.4796404 0.0023982981 6.314317e-04 2.648750e-03 1 183975097 183975214 118 - 1.312 1.107 -0.725
ENSG00000198756 E019 14.3596841 0.0013449122 5.866059e-03 1.826151e-02 1 183978410 183978520 111 - 1.259 1.108 -0.538
ENSG00000198756 E020 7.6706216 0.0021814516 2.145828e-01 3.439523e-01 1 184037095 184037302 208 - 0.968 0.912 -0.210
ENSG00000198756 E021 3.6471565 0.0045589884 2.720071e-01 4.108342e-01 1 184037303 184037580 278 - 0.711 0.626 -0.362
ENSG00000198756 E022 4.0329058 0.0040772816 1.479127e-02 4.002288e-02 1 184037581 184037755 175 - 0.821 0.545 -1.165
ENSG00000198756 E023 0.4502799 0.0338091927 8.217870e-02 1.629486e-01 1 184051595 184051622 28 - 0.276 0.000 -13.380