ENSG00000198752

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361246 ENSG00000198752 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC42BPB protein_coding protein_coding 27.2029 23.66696 23.84596 1.951992 0.5025583 0.0108658 12.401300 10.932493 11.962571 1.4231338 0.6159757 0.1297916 0.45835833 0.45890000 0.50320000 0.044300000 7.536371e-01 4.426288e-33 FALSE TRUE
ENST00000559043 ENSG00000198752 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC42BPB protein_coding protein_coding 27.2029 23.66696 23.84596 1.951992 0.5025583 0.0108658 1.780409 0.000000 2.711708 0.0000000 0.1030266 8.0883686 0.06738333 0.00000000 0.11396667 0.113966667 4.426288e-33 4.426288e-33 FALSE TRUE
ENST00000559245 ENSG00000198752 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC42BPB protein_coding retained_intron 27.2029 23.66696 23.84596 1.951992 0.5025583 0.0108658 3.167871 2.039588 2.205307 0.4617323 0.5542295 0.1121728 0.11205000 0.08653333 0.09160000 0.005066667 9.898920e-01 4.426288e-33 FALSE FALSE
ENST00000560492 ENSG00000198752 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC42BPB protein_coding retained_intron 27.2029 23.66696 23.84596 1.951992 0.5025583 0.0108658 2.892502 2.533259 2.915413 0.3020822 0.2937958 0.2019617 0.10549167 0.10676667 0.12196667 0.015200000 7.178272e-01 4.426288e-33   FALSE
MSTRG.10219.1 ENSG00000198752 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC42BPB protein_coding   27.2029 23.66696 23.84596 1.951992 0.5025583 0.0108658 4.501747 7.015096 2.201725 0.3273495 0.6632157 -1.6673458 0.16641250 0.29923333 0.09156667 -0.207666667 3.469760e-04 4.426288e-33 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198752 E001 1.2595872 0.1756343228 7.883704e-01 8.645196e-01 14 102931846 102931881 36 - 0.389 0.333 -0.329
ENSG00000198752 E002 0.5911862 0.0183569157 2.126207e-02 5.413879e-02 14 102932252 102932379 128 - 0.389 0.000 -12.600
ENSG00000198752 E003 709.6477149 0.0076639274 1.003009e-12 2.461998e-11 14 102932380 102933448 1069 - 2.628 2.943 1.050
ENSG00000198752 E004 414.1008694 0.0010355765 2.491570e-20 1.652726e-18 14 102933449 102933843 395 - 2.456 2.684 0.760
ENSG00000198752 E005 158.3190884 0.0010513223 5.691478e-07 4.982364e-06 14 102938104 102938174 71 - 2.077 2.251 0.583
ENSG00000198752 E006 182.5931563 0.0011199710 1.755214e-05 1.102556e-04 14 102938306 102938411 106 - 2.159 2.303 0.481
ENSG00000198752 E007 202.2991062 0.0001789788 4.824675e-06 3.448352e-05 14 102939610 102939727 118 - 2.214 2.342 0.427
ENSG00000198752 E008 177.7611945 0.0002086852 5.072899e-03 1.613007e-02 14 102939830 102939907 78 - 2.187 2.273 0.288
ENSG00000198752 E009 112.3215920 0.0011608611 7.720960e-01 8.529036e-01 14 102939908 102939915 8 - 2.031 2.051 0.066
ENSG00000198752 E010 136.9255435 0.0008015779 5.656209e-01 6.926779e-01 14 102939916 102939947 32 - 2.136 2.126 -0.033
ENSG00000198752 E011 174.2963442 0.0002605344 8.820486e-01 9.284549e-01 14 102940046 102940130 85 - 2.226 2.239 0.044
ENSG00000198752 E012 3.8146803 0.0048611598 2.964784e-02 7.127693e-02 14 102940131 102940226 96 - 0.832 0.524 -1.307
ENSG00000198752 E013 167.0754554 0.0002179883 2.035761e-02 5.223741e-02 14 102940227 102940324 98 - 2.168 2.243 0.250
ENSG00000198752 E014 36.2964149 0.0006093456 6.805170e-02 1.401340e-01 14 102940325 102940747 423 - 1.615 1.517 -0.333
ENSG00000198752 E015 20.6417795 0.0121800341 2.480885e-01 3.836736e-01 14 102941244 102941398 155 - 1.246 1.364 0.412
ENSG00000198752 E016 8.6033961 0.0694000558 3.030633e-01 4.449737e-01 14 102943813 102943890 78 - 1.061 0.915 -0.543
ENSG00000198752 E017 142.8524019 0.0002168052 2.112214e-01 3.399363e-01 14 102943891 102944010 120 - 2.117 2.164 0.157
ENSG00000198752 E018 95.5127957 0.0003034540 8.227508e-02 1.631029e-01 14 102944011 102944042 32 - 1.927 2.001 0.247
ENSG00000198752 E019 89.4579871 0.0003367801 4.299136e-02 9.652611e-02 14 102944043 102944074 32 - 1.891 1.978 0.292
ENSG00000198752 E020 360.6029130 0.0002094480 2.789573e-02 6.780472e-02 14 102944075 102944487 413 - 2.513 2.565 0.175
ENSG00000198752 E021 0.7675920 0.0157256373 4.843545e-01 6.223768e-01 14 102945174 102945331 158 - 0.319 0.200 -0.893
ENSG00000198752 E022 131.7558518 0.0003226006 4.900247e-01 6.273777e-01 14 102945662 102945724 63 - 2.091 2.122 0.104
ENSG00000198752 E023 244.3240853 0.0001742136 7.204176e-02 1.467269e-01 14 102946468 102946684 217 - 2.345 2.396 0.171
ENSG00000198752 E024 144.9169278 0.0002260459 2.589042e-01 3.962341e-01 14 102947721 102947802 82 - 2.125 2.168 0.144
ENSG00000198752 E025 129.1577935 0.0002376516 8.005012e-01 8.728456e-01 14 102949765 102949856 92 - 2.092 2.109 0.057
ENSG00000198752 E026 106.5729413 0.0013033332 6.924223e-01 7.936768e-01 14 102949857 102949904 48 - 2.019 2.014 -0.018
ENSG00000198752 E027 130.3712681 0.0002294249 4.795834e-01 6.179479e-01 14 102950466 102950602 137 - 2.115 2.101 -0.044
ENSG00000198752 E028 131.8644856 0.0002963863 3.825900e-01 5.267940e-01 14 102952498 102952603 106 - 2.090 2.127 0.124
ENSG00000198752 E029 55.2281101 0.0004324230 1.235071e-01 2.249537e-01 14 102954198 102954275 78 - 1.773 1.708 -0.219
ENSG00000198752 E030 124.5031727 0.0015228785 8.363264e-01 8.976489e-01 14 102954602 102954688 87 - 2.087 2.089 0.007
ENSG00000198752 E031 1.0017226 0.0125799395 7.777266e-01 8.569749e-01 14 102956240 102956290 51 - 0.319 0.274 -0.307
ENSG00000198752 E032 118.0973732 0.0002832979 8.687505e-01 9.196385e-01 14 102959631 102959710 80 - 2.057 2.071 0.048
ENSG00000198752 E033 123.4247429 0.0002864106 2.172587e-02 5.510645e-02 14 102963061 102963155 95 - 2.123 2.058 -0.218
ENSG00000198752 E034 142.7108820 0.0002679882 2.870174e-02 6.941112e-02 14 102964502 102964650 149 - 2.176 2.119 -0.191
ENSG00000198752 E035 142.0983273 0.0020295304 4.022382e-01 5.459554e-01 14 102966282 102966387 106 - 2.153 2.134 -0.064
ENSG00000198752 E036 133.0310647 0.0016569133 6.106065e-01 7.299257e-01 14 102967046 102967170 125 - 2.117 2.110 -0.024
ENSG00000198752 E037 103.9082657 0.0025244081 7.431045e-07 6.347970e-06 14 102968253 102968358 106 - 2.117 1.919 -0.664
ENSG00000198752 E038 157.5959602 0.0015098663 2.724493e-11 5.284061e-10 14 102968472 102968716 245 - 2.302 2.089 -0.711
ENSG00000198752 E039 110.2818456 0.0047359544 1.495374e-02 4.038001e-02 14 102970151 102970261 111 - 2.091 1.990 -0.338
ENSG00000198752 E040 191.3424065 0.0010676491 1.978713e-01 3.235608e-01 14 102971919 102972161 243 - 2.288 2.260 -0.092
ENSG00000198752 E041 129.5371982 0.0016287666 1.643314e-01 2.808133e-01 14 102974016 102974149 134 - 2.125 2.086 -0.132
ENSG00000198752 E042 119.4820448 0.0058647148 3.252512e-02 7.685325e-02 14 102975684 102975803 120 - 2.121 2.030 -0.308
ENSG00000198752 E043 156.2992840 0.0035385272 3.080698e-04 1.412427e-03 14 102975883 102976049 167 - 2.259 2.126 -0.443
ENSG00000198752 E044 103.4756603 0.0003156495 2.178472e-07 2.073270e-06 14 102978126 102978205 80 - 2.102 1.930 -0.580
ENSG00000198752 E045 193.0016352 0.0007574058 5.645651e-12 1.223463e-10 14 102980773 102981021 249 - 2.377 2.193 -0.615
ENSG00000198752 E046 181.7292470 0.0096948069 1.023931e-05 6.790372e-05 14 102983556 102983756 201 - 2.370 2.150 -0.735
ENSG00000198752 E047 0.1515154 0.0437186108 3.930355e-01   14 102986298 102986486 189 - 0.134 0.000 -10.600
ENSG00000198752 E048 80.1911276 0.0122205705 5.937402e-04 2.510709e-03 14 102986487 102986509 23 - 2.012 1.804 -0.700
ENSG00000198752 E049 110.1118341 0.0183678996 1.138993e-04 5.856553e-04 14 102986510 102986580 71 - 2.173 1.911 -0.878
ENSG00000198752 E050 119.6176778 0.0046508345 6.112458e-09 7.852356e-08 14 102999565 102999713 149 - 2.203 1.949 -0.849
ENSG00000198752 E051 81.6252651 0.0104969901 1.282403e-04 6.511414e-04 14 103003928 103004023 96 - 2.026 1.800 -0.761
ENSG00000198752 E052 0.1482932 0.0425996863 6.000516e-01   14 103004024 103004279 256 - 0.000 0.111 9.708
ENSG00000198752 E053 68.7737025 0.0003606004 4.019906e-07 3.623021e-06 14 103008472 103008555 84 - 1.944 1.737 -0.697
ENSG00000198752 E054 67.1083404 0.0024728521 3.360594e-06 2.488876e-05 14 103012097 103012188 92 - 1.938 1.723 -0.726
ENSG00000198752 E055 71.4942034 0.0186049290 4.261851e-08 4.662711e-07 14 103056999 103057549 551 - 2.050 1.638 -1.391