ENSG00000198742

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361368 ENSG00000198742 HEK293_OSMI2_2hA HEK293_TMG_2hB SMURF1 protein_coding protein_coding 8.426189 8.177085 8.839267 0.1585567 0.01247648 0.112208 7.112452 7.3842646 6.607426 0.1156656 0.3033722 -0.1601364 0.8446042 0.90330000 0.7475333 -0.1557667 0.003807519 2.084558e-06 FALSE TRUE
MSTRG.30293.3 ENSG00000198742 HEK293_OSMI2_2hA HEK293_TMG_2hB SMURF1 protein_coding   8.426189 8.177085 8.839267 0.1585567 0.01247648 0.112208 1.093431 0.7431453 1.721936 0.1409775 0.2073564 1.2013852 0.1294958 0.09046667 0.1948000 0.1043333 0.044721985 2.084558e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198742 E001 0.7748771 0.1596877400 4.301187e-02 9.656416e-02 7 99027440 99027440 1 - 0.000 0.412 10.696
ENSG00000198742 E002 82.1185168 0.0035302121 7.100550e-16 2.735850e-14 7 99027441 99027774 334 - 1.627 2.063 1.471
ENSG00000198742 E003 752.3892169 0.0033054810 5.532046e-04 2.358621e-03 7 99027775 99030683 2909 - 2.816 2.919 0.342
ENSG00000198742 E004 77.2297878 0.0007471679 3.723525e-01 5.168222e-01 7 99033037 99033112 76 - 1.852 1.917 0.220
ENSG00000198742 E005 35.4601280 0.0134893146 5.475769e-01 6.776064e-01 7 99033113 99033121 9 - 1.513 1.588 0.254
ENSG00000198742 E006 114.2795497 0.0004350814 6.529295e-01 7.635353e-01 7 99035515 99035716 202 - 2.033 2.077 0.147
ENSG00000198742 E007 83.9853804 0.0030049429 5.495429e-01 6.792590e-01 7 99037067 99037187 121 - 1.925 1.926 0.005
ENSG00000198742 E008 82.2132469 0.0004424412 8.156202e-02 1.619979e-01 7 99038388 99038525 138 - 1.938 1.899 -0.130
ENSG00000198742 E009 84.5448897 0.0003487519 7.281869e-01 8.207071e-01 7 99040378 99040556 179 - 1.920 1.935 0.052
ENSG00000198742 E010 69.1427173 0.0081358227 7.440750e-01 8.325338e-01 7 99042118 99042232 115 - 1.814 1.863 0.163
ENSG00000198742 E011 77.6633950 0.0032291682 9.851988e-02 1.882365e-01 7 99045698 99045801 104 - 1.918 1.869 -0.165
ENSG00000198742 E012 94.9268771 0.0008254845 5.738118e-02 1.221316e-01 7 99047684 99047882 199 - 2.002 1.959 -0.142
ENSG00000198742 E013 68.4069405 0.0004249202 8.422953e-05 4.480550e-04 7 99049563 99049709 147 - 1.911 1.774 -0.461
ENSG00000198742 E014 0.5117906 0.2191683402 5.990243e-01 7.205109e-01 7 99050915 99050992 78 - 0.218 0.124 -0.979
ENSG00000198742 E015 50.4387389 0.0004491097 2.060045e-03 7.411679e-03 7 99051357 99051441 85 - 1.773 1.652 -0.411
ENSG00000198742 E016 28.5705447 0.0007248441 1.759727e-01 2.959623e-01 7 99052205 99052211 7 - 1.500 1.442 -0.201
ENSG00000198742 E017 75.1330602 0.0003846204 1.247525e-02 3.467688e-02 7 99052212 99052446 235 - 1.918 1.846 -0.241
ENSG00000198742 E018 45.4607722 0.0005213225 5.271667e-02 1.139849e-01 7 99054790 99054865 76 - 1.704 1.633 -0.241
ENSG00000198742 E019 48.9056926 0.0005166227 4.028126e-03 1.322144e-02 7 99057205 99057270 66 - 1.754 1.639 -0.388
ENSG00000198742 E020 64.5195177 0.0028710404 1.995903e-02 5.140055e-02 7 99057418 99057551 134 - 1.858 1.771 -0.294
ENSG00000198742 E021 52.7006064 0.0077463157 7.830197e-02 1.567504e-01 7 99060599 99060707 109 - 1.768 1.685 -0.281
ENSG00000198742 E022 27.6151625 0.0009285560 4.261718e-03 1.387495e-02 7 99061799 99061837 39 - 1.530 1.370 -0.553
ENSG00000198742 E023 2.0692144 0.0068589569 3.603463e-04 1.620301e-03 7 99081075 99081427 353 - 0.719 0.122 -3.705
ENSG00000198742 E024 0.0000000       7 99120643 99120767 125 -      
ENSG00000198742 E025 1.2126750 0.0162833303 2.164030e-02 5.492839e-02 7 99121146 99121203 58 - 0.516 0.122 -2.811
ENSG00000198742 E026 28.9451025 0.0075271756 2.874642e-04 1.328987e-03 7 99143726 99144108 383 - 1.589 1.340 -0.856