ENSG00000198740

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000430262 ENSG00000198740 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF652 protein_coding protein_coding 3.961493 3.740266 3.500882 1.126941 0.1661334 -0.09515919 1.532464 0.6940382 2.1030999 0.0427520 0.09414931 1.5856355 0.3871708 0.2113667 0.6016667 0.39030000 5.694329e-06 3.697734e-11 FALSE TRUE
ENST00000508237 ENSG00000198740 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF652 protein_coding nonsense_mediated_decay 3.961493 3.740266 3.500882 1.126941 0.1661334 -0.09515919 0.701451 0.5607946 0.7007788 0.2940235 0.09711563 0.3164289 0.1798125 0.1368000 0.2029667 0.06616667 6.608518e-01 3.697734e-11 TRUE TRUE
ENST00000513488 ENSG00000198740 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF652 protein_coding processed_transcript 3.961493 3.740266 3.500882 1.126941 0.1661334 -0.09515919 1.652856 2.4614832 0.5940747 0.8251999 0.10949952 -2.0325781 0.4149542 0.6446000 0.1674667 -0.47713333 3.697734e-11 3.697734e-11 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198740 E001 0.0000000       17 49289206 49289207 2 -      
ENSG00000198740 E002 56.1925924 0.0054295387 1.180801e-19 7.225426e-18 17 49289208 49289659 452 - 1.412 2.018 2.057
ENSG00000198740 E003 46.2875170 0.0191922854 8.759502e-06 5.898629e-05 17 49289660 49289728 69 - 1.428 1.892 1.578
ENSG00000198740 E004 222.2655902 0.0171493237 1.972601e-05 1.225176e-04 17 49289729 49291460 1732 - 2.197 2.496 0.995
ENSG00000198740 E005 11.4127530 0.0427983108 3.649931e-01 5.093372e-01 17 49291461 49291487 27 - 1.115 1.039 -0.273
ENSG00000198740 E006 26.3695030 0.0009345072 2.195237e-02 5.557603e-02 17 49291488 49291695 208 - 1.463 1.377 -0.296
ENSG00000198740 E007 101.1041305 0.0090472982 4.708435e-01 6.100355e-01 17 49291696 49293593 1898 - 1.998 2.013 0.053
ENSG00000198740 E008 6.5181667 0.1064055298 5.242645e-01 6.578508e-01 17 49293594 49293653 60 - 0.898 0.801 -0.377
ENSG00000198740 E009 30.3957612 0.0413155075 3.395136e-03 1.142428e-02 17 49293654 49294564 911 - 1.584 1.288 -1.024
ENSG00000198740 E010 92.8990404 0.0080629056 7.120570e-17 3.121895e-15 17 49294565 49298105 3541 - 2.092 1.669 -1.425
ENSG00000198740 E011 28.8213123 0.0008810928 6.427720e-05 3.523677e-04 17 49298106 49298479 374 - 1.540 1.344 -0.675
ENSG00000198740 E012 10.5143253 0.0060699195 1.165115e-01 2.149727e-01 17 49298480 49298631 152 - 1.090 0.983 -0.391
ENSG00000198740 E013 16.7436128 0.0012336535 1.132062e-05 7.428671e-05 17 49298632 49298924 293 - 1.345 1.020 -1.157
ENSG00000198740 E014 13.7195244 0.0056644368 3.030739e-02 7.256973e-02 17 49311312 49311456 145 - 1.217 1.070 -0.526
ENSG00000198740 E015 13.5480900 0.0013234039 2.011279e-02 5.172481e-02 17 49311927 49312042 116 - 1.217 1.071 -0.525
ENSG00000198740 E016 15.3562256 0.0041736735 1.445089e-01 2.541570e-01 17 49312698 49312845 148 - 1.236 1.169 -0.236
ENSG00000198740 E017 28.0522024 0.0396500975 2.863211e-01 4.267130e-01 17 49316826 49317365 540 - 1.488 1.402 -0.295
ENSG00000198740 E018 35.7868577 0.0389677043 1.081799e-03 4.241731e-03 17 49317366 49317983 618 - 1.665 1.331 -1.146
ENSG00000198740 E019 0.5922303 0.0178275909 5.329568e-01 6.652242e-01 17 49322385 49322508 124 - 0.240 0.155 -0.777
ENSG00000198740 E020 4.5426081 0.0034615290 2.581800e-02 6.356426e-02 17 49361909 49362250 342 - 0.823 0.555 -1.129
ENSG00000198740 E021 0.5181333 0.0217681645 8.435488e-01 9.025782e-01 17 49362413 49362473 61 - 0.174 0.156 -0.188