ENSG00000198728

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000425280 ENSG00000198728 HEK293_OSMI2_2hA HEK293_TMG_2hB LDB1 protein_coding protein_coding 45.90751 64.5436 33.15399 2.801432 0.9242745 -0.9608799 4.231886 0.00000 6.721024 0.0000000 0.1674710 9.394682 0.1180292 0.0000 0.2030667 0.20306667 9.621746e-81 9.621746e-81 FALSE TRUE
ENST00000673968 ENSG00000198728 HEK293_OSMI2_2hA HEK293_TMG_2hB LDB1 protein_coding protein_coding 45.90751 64.5436 33.15399 2.801432 0.9242745 -0.9608799 31.976031 52.25593 20.536130 2.5634389 0.5083502 -1.347004 0.6689750 0.8095 0.6196000 -0.18990000 3.618081e-10 9.621746e-81 FALSE TRUE
MSTRG.4536.2 ENSG00000198728 HEK293_OSMI2_2hA HEK293_TMG_2hB LDB1 protein_coding   45.90751 64.5436 33.15399 2.801432 0.9242745 -0.9608799 7.453858 11.25641 4.301225 0.7959163 0.6088786 -1.385859 0.1559083 0.1746 0.1308333 -0.04376667 4.345697e-01 9.621746e-81 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198728 E001 279.566060 0.0058976255 3.716608e-04 1.664815e-03 10 102106489 102106639 151 - 2.257 2.449 0.638
ENSG00000198728 E002 1607.314055 0.0043461790 9.992297e-12 2.081375e-10 10 102106640 102107559 920 - 2.991 3.213 0.740
ENSG00000198728 E003 1286.000110 0.0001514471 2.316301e-13 6.258970e-12 10 102107560 102108323 764 - 2.978 3.090 0.374
ENSG00000198728 E004 113.270703 0.0003635836 2.001873e-05 1.241661e-04 10 102109029 102109034 6 - 2.093 1.970 -0.412
ENSG00000198728 E005 532.308554 0.0001875024 3.442482e-03 1.155952e-02 10 102109035 102109177 143 - 2.695 2.674 -0.069
ENSG00000198728 E006 488.922159 0.0007253900 4.434408e-04 1.941541e-03 10 102109384 102109507 124 - 2.673 2.630 -0.143
ENSG00000198728 E007 376.047421 0.0001414684 6.501691e-03 1.992729e-02 10 102109600 102109683 84 - 2.546 2.520 -0.085
ENSG00000198728 E008 347.330867 0.0008946447 7.379711e-02 1.495880e-01 10 102109921 102110043 123 - 2.504 2.489 -0.047
ENSG00000198728 E009 7.077013 0.0259927058 4.039649e-01 5.477331e-01 10 102110392 102110528 137 - 0.931 0.836 -0.362
ENSG00000198728 E010 426.807038 0.0020904111 5.166329e-03 1.638090e-02 10 102110529 102110701 173 - 2.616 2.570 -0.155
ENSG00000198728 E011 378.084513 0.0051163260 3.069430e-03 1.047077e-02 10 102110869 102110971 103 - 2.589 2.508 -0.270
ENSG00000198728 E012 366.247417 0.0027621915 2.095144e-06 1.622659e-05 10 102111069 102111144 76 - 2.597 2.481 -0.386
ENSG00000198728 E013 287.299133 0.0036817195 1.033445e-05 6.848195e-05 10 102111256 102111300 45 - 2.500 2.372 -0.426
ENSG00000198728 E014 273.677029 0.0016810979 3.264870e-09 4.399146e-08 10 102111434 102111536 103 - 2.489 2.346 -0.479
ENSG00000198728 E015 65.828565 0.0003913821 1.058486e-07 1.070505e-06 10 102114406 102114946 541 - 1.916 1.705 -0.711
ENSG00000198728 E016 123.191128 0.0056687588 1.509677e-10 2.584061e-09 10 102120086 102120479 394 - 2.225 1.945 -0.935