ENSG00000198722

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378495 ENSG00000198722 HEK293_OSMI2_2hA HEK293_TMG_2hB UNC13B protein_coding protein_coding 15.29153 15.48653 14.4822 1.228797 0.131622 -0.09666792 7.161225 4.981023 8.085416 1.7589192 0.23196479 0.6977696 0.4722458 0.3125000 0.5581333 0.2456333 8.951135e-02 1.463493e-08 FALSE TRUE
ENST00000637271 ENSG00000198722 HEK293_OSMI2_2hA HEK293_TMG_2hB UNC13B protein_coding processed_transcript 15.29153 15.48653 14.4822 1.228797 0.131622 -0.09666792 2.099334 5.275154 0.000000 1.6641639 0.00000000 -9.0458018 0.1303708 0.3541000 0.0000000 -0.3541000 1.463493e-08 1.463493e-08 FALSE TRUE
MSTRG.32610.1 ENSG00000198722 HEK293_OSMI2_2hA HEK293_TMG_2hB UNC13B protein_coding   15.29153 15.48653 14.4822 1.228797 0.131622 -0.09666792 5.947537 5.230350 6.287180 0.8453983 0.08681699 0.2650427 0.3919458 0.3334333 0.4343333 0.1009000 1.188633e-01 1.463493e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198722 E001 3.0269298 0.0050177179 3.799003e-03 1.257882e-02 9 35161974 35161991 18 + 0.791 0.363 -1.983
ENSG00000198722 E002 5.4727120 0.0701787974 1.566746e-01 2.706737e-01 9 35161992 35162001 10 + 0.909 0.718 -0.750
ENSG00000198722 E003 7.3840007 0.0835846432 5.525204e-01 6.818044e-01 9 35162002 35162008 7 + 0.942 0.912 -0.116
ENSG00000198722 E004 30.5315917 0.0045413491 2.421954e-03 8.527683e-03 9 35162009 35162061 53 + 1.586 1.413 -0.594
ENSG00000198722 E005 35.5513577 0.0024477244 1.812859e-04 8.835395e-04 9 35162062 35162103 42 + 1.659 1.464 -0.665
ENSG00000198722 E006 61.5266749 0.0198037939 3.781415e-03 1.252978e-02 9 35162104 35162305 202 + 1.888 1.699 -0.638
ENSG00000198722 E007 0.0000000       9 35227798 35227933 136 +      
ENSG00000198722 E008 28.9482228 0.0025165569 6.951115e-04 2.881234e-03 9 35228015 35228044 30 + 1.571 1.379 -0.661
ENSG00000198722 E009 56.9546914 0.0080582155 4.148524e-05 2.382025e-04 9 35231120 35231219 100 + 1.870 1.650 -0.742
ENSG00000198722 E010 76.5293926 0.0080826741 1.280925e-04 6.504955e-04 9 35236469 35236586 118 + 1.981 1.795 -0.629
ENSG00000198722 E011 80.0386302 0.0112934542 3.713104e-03 1.233472e-02 9 35237703 35237826 124 + 1.981 1.835 -0.493
ENSG00000198722 E012 53.2405957 0.0102408821 2.298180e-02 5.771023e-02 9 35243291 35243364 74 + 1.793 1.679 -0.388
ENSG00000198722 E013 48.8361682 0.0136013262 1.297196e-02 3.584451e-02 9 35258993 35259050 58 + 1.772 1.622 -0.509
ENSG00000198722 E014 0.1515154 0.0433797788 4.633452e-01   9 35291069 35291104 36 + 0.122 0.000 -9.821
ENSG00000198722 E015 98.8891506 0.0145135253 1.173720e-03 4.552221e-03 9 35295696 35295930 235 + 2.086 1.911 -0.587
ENSG00000198722 E016 0.0000000       9 35300166 35308412 8247 +      
ENSG00000198722 E017 127.6115745 0.0023001493 6.851743e-07 5.894833e-06 9 35310467 35310781 315 + 2.186 2.032 -0.514
ENSG00000198722 E018 63.5903931 0.0004180420 4.757427e-05 2.694894e-04 9 35313899 35313989 91 + 1.885 1.743 -0.478
ENSG00000198722 E019 0.0000000       9 35341830 35342344 515 +      
ENSG00000198722 E020 0.2955422 0.0293549614 9.599912e-01   9 35351294 35353810 2517 + 0.122 0.123 0.015
ENSG00000198722 E021 0.1472490 0.0435353877 4.637449e-01   9 35364545 35364567 23 + 0.122 0.000 -9.819
ENSG00000198722 E022 48.9630436 0.0004943509 8.650163e-04 3.491005e-03 9 35366947 35366993 47 + 1.765 1.636 -0.439
ENSG00000198722 E023 54.9213851 0.0056112949 1.845584e-04 8.973649e-04 9 35370318 35370396 79 + 1.838 1.652 -0.629
ENSG00000198722 E024 0.0000000       9 35371934 35371939 6 +      
ENSG00000198722 E025 56.7755434 0.0035765654 3.001498e-02 7.198875e-02 9 35375127 35375201 75 + 1.802 1.720 -0.278
ENSG00000198722 E026 99.7930348 0.0042341769 6.029934e-04 2.544046e-03 9 35376028 35376247 220 + 2.065 1.937 -0.431
ENSG00000198722 E027 123.7931294 0.0085628542 3.012319e-02 7.220560e-02 9 35377468 35377695 228 + 2.137 2.052 -0.286
ENSG00000198722 E028 117.6466778 0.0031654720 4.145855e-05 2.380709e-04 9 35378295 35378436 142 + 2.142 2.005 -0.459
ENSG00000198722 E029 139.9740048 0.0043577984 5.188330e-03 1.644053e-02 9 35380470 35380639 170 + 2.193 2.106 -0.290
ENSG00000198722 E030 104.9344890 0.0003015388 5.409610e-04 2.313239e-03 9 35381100 35381215 116 + 2.069 1.986 -0.276
ENSG00000198722 E031 119.5740124 0.0002726549 1.555096e-02 4.173808e-02 9 35381556 35381719 164 + 2.102 2.060 -0.139
ENSG00000198722 E032 109.1546974 0.0002780370 8.337867e-03 2.463678e-02 9 35382357 35382507 151 + 2.070 2.018 -0.175
ENSG00000198722 E033 78.8573764 0.0005804046 4.777190e-02 1.052146e-01 9 35384246 35384314 69 + 1.928 1.886 -0.142
ENSG00000198722 E034 64.1466055 0.0043844516 7.841534e-01 8.615360e-01 9 35385724 35385813 90 + 1.784 1.837 0.178
ENSG00000198722 E035 109.4497830 0.0070709579 6.160662e-01 7.342033e-01 9 35386165 35386293 129 + 2.035 2.047 0.041
ENSG00000198722 E036 46.0081859 0.0039922106 2.131294e-01 3.422424e-01 9 35389846 35389848 3 + 1.689 1.650 -0.133
ENSG00000198722 E037 108.5453067 0.0063567398 4.956709e-01 6.324482e-01 9 35389849 35389973 125 + 2.037 2.036 -0.005
ENSG00000198722 E038 90.8041784 0.0003297839 2.368354e-01 3.705170e-01 9 35390629 35390714 86 + 1.966 1.959 -0.024
ENSG00000198722 E039 84.1903138 0.0004762811 4.357857e-01 5.779572e-01 9 35396476 35396537 62 + 1.928 1.935 0.023
ENSG00000198722 E040 83.7872776 0.0003189176 3.154040e-01 4.581734e-01 9 35396538 35396602 65 + 1.932 1.930 -0.005
ENSG00000198722 E041 99.7537606 0.0003039519 2.909356e-01 4.317509e-01 9 35396841 35396937 97 + 1.962 2.036 0.250
ENSG00000198722 E042 133.2972759 0.0002827615 2.218763e-02 5.606000e-02 9 35397167 35397310 144 + 2.069 2.177 0.362
ENSG00000198722 E043 113.7783502 0.0066585711 3.124453e-01 4.549717e-01 9 35397635 35397712 78 + 2.011 2.099 0.295
ENSG00000198722 E044 114.6079707 0.0028796565 2.923591e-01 4.333235e-01 9 35398211 35398288 78 + 2.019 2.099 0.266
ENSG00000198722 E045 104.8622978 0.0003271516 8.000371e-02 1.595652e-01 9 35398554 35398642 89 + 1.971 2.069 0.329
ENSG00000198722 E046 141.5701704 0.0011472051 1.233719e-02 3.434151e-02 9 35398882 35399034 153 + 2.085 2.205 0.400
ENSG00000198722 E047 148.7311365 0.0002651884 3.388701e-01 4.827783e-01 9 35399161 35399284 124 + 2.142 2.208 0.218
ENSG00000198722 E048 111.3189654 0.0002609615 8.995109e-01 9.398801e-01 9 35399392 35399448 57 + 2.034 2.066 0.110
ENSG00000198722 E049 129.1579093 0.0013855180 2.635459e-01 4.014695e-01 9 35399649 35399729 81 + 2.072 2.148 0.253
ENSG00000198722 E050 156.8541948 0.0008663883 9.324677e-02 1.801977e-01 9 35400296 35400443 148 + 2.149 2.238 0.296
ENSG00000198722 E051 0.0000000       9 35401951 35402007 57 +      
ENSG00000198722 E052 118.2874041 0.0052823462 2.016420e-02 5.182816e-02 9 35403167 35403259 93 + 1.993 2.136 0.482
ENSG00000198722 E053 187.4664734 0.0028016745 1.440212e-02 3.913785e-02 9 35403440 35403599 160 + 2.205 2.327 0.406
ENSG00000198722 E054 969.1293862 0.0052479749 3.171877e-15 1.123812e-13 9 35403748 35405338 1591 + 2.810 3.093 0.938