ENSG00000198720

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394859 ENSG00000198720 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13B protein_coding protein_coding 12.42943 15.18251 10.77908 1.044436 0.9698526 -0.4937887 1.4131877 1.8876554 1.4644093 0.5346956 0.1638057 -0.36408100 0.10839167 0.1206333 0.13646667 0.015833333 0.844107328 0.003444437 FALSE TRUE
ENST00000487527 ENSG00000198720 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13B protein_coding retained_intron 12.42943 15.18251 10.77908 1.044436 0.9698526 -0.4937887 4.3834445 6.8365572 2.9911572 0.5148930 0.2715120 -1.18985981 0.34496250 0.4559667 0.27776667 -0.178200000 0.030614997 0.003444437 FALSE TRUE
ENST00000578811 ENSG00000198720 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13B protein_coding retained_intron 12.42943 15.18251 10.77908 1.044436 0.9698526 -0.4937887 0.7542995 1.1457742 0.9472936 0.5742852 0.4790252 -0.27182616 0.05810417 0.0707000 0.08063333 0.009933333 1.000000000 0.003444437 FALSE FALSE
ENST00000578943 ENSG00000198720 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13B protein_coding retained_intron 12.42943 15.18251 10.77908 1.044436 0.9698526 -0.4937887 1.1085945 0.7133684 1.3004026 0.1815747 0.1691014 0.85720759 0.09636250 0.0480000 0.12090000 0.072900000 0.038308896 0.003444437 FALSE TRUE
MSTRG.14037.3 ENSG00000198720 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13B protein_coding   12.42943 15.18251 10.77908 1.044436 0.9698526 -0.4937887 3.1850087 3.4818647 3.6521770 0.3772360 0.3848531 0.06870383 0.26657917 0.2281333 0.33836667 0.110233333 0.003444437 0.003444437 FALSE TRUE
MSTRG.14037.7 ENSG00000198720 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13B protein_coding   12.42943 15.18251 10.77908 1.044436 0.9698526 -0.4937887 0.9686712 1.1172925 0.3254235 0.3831156 0.3254235 -1.74880606 0.07917500 0.0766000 0.03663333 -0.039966667 0.305066748 0.003444437 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198720 E001 0.0000000       17 29589769 29589782 14 +      
ENSG00000198720 E002 0.1515154 0.0425054158 2.813094e-01   17 29589783 29589862 80 + 0.152 0.000 -10.692
ENSG00000198720 E003 0.0000000       17 29591643 29591700 58 +      
ENSG00000198720 E004 5.0272415 0.0031598602 5.142125e-05 2.888540e-04 17 29593132 29593458 327 + 1.028 0.514 -2.090
ENSG00000198720 E005 0.8815316 0.0137769568 9.840645e-04 3.904969e-03 17 29593459 29593467 9 + 0.547 0.000 -13.281
ENSG00000198720 E006 2.4930898 0.0537966296 1.077336e-03 4.225807e-03 17 29593468 29593537 70 + 0.810 0.246 -2.843
ENSG00000198720 E007 22.1635952 0.0194800060 3.041033e-01 4.461129e-01 17 29593538 29593735 198 + 1.240 1.378 0.481
ENSG00000198720 E008 0.1817044 0.0396566637 8.236629e-01   17 29599383 29599411 29 + 0.000 0.098 8.949
ENSG00000198720 E009 0.0000000       17 29599412 29599448 37 +      
ENSG00000198720 E010 47.8248718 0.0287812255 6.122584e-01 7.312293e-01 17 29607742 29607877 136 + 1.599 1.688 0.304
ENSG00000198720 E011 31.1438462 0.0007542971 4.031311e-01 5.469166e-01 17 29607878 29607985 108 + 1.425 1.505 0.275
ENSG00000198720 E012 32.6638609 0.0006494082 3.144677e-01 4.571767e-01 17 29607986 29607999 14 + 1.432 1.522 0.310
ENSG00000198720 E013 56.3868330 0.0137132262 6.470781e-01 7.588225e-01 17 29608000 29608110 111 + 1.686 1.749 0.215
ENSG00000198720 E014 61.2818993 0.0028146245 9.323750e-01 9.613975e-01 17 29608195 29608240 46 + 1.745 1.775 0.102
ENSG00000198720 E015 11.0634778 0.0053187740 1.922943e-06 1.501199e-05 17 29608652 29608850 199 + 1.308 0.848 -1.677
ENSG00000198720 E016 103.6141622 0.0005162400 5.193007e-02 1.126002e-01 17 29608851 29608994 144 + 2.020 1.976 -0.149
ENSG00000198720 E017 109.6069199 0.0037383617 1.769186e-01 2.972356e-01 17 29609086 29609275 190 + 2.039 2.006 -0.112
ENSG00000198720 E018 2.2820356 0.0065422952 2.965653e-01 4.377973e-01 17 29609276 29609354 79 + 0.596 0.442 -0.737
ENSG00000198720 E019 78.5762468 0.0004771544 1.269122e-02 3.518576e-02 17 29609355 29609421 67 + 1.923 1.847 -0.255
ENSG00000198720 E020 87.3950630 0.0004251573 4.670470e-04 2.033969e-03 17 29610685 29610766 82 + 1.990 1.882 -0.363
ENSG00000198720 E021 79.9493313 0.0005118897 7.476491e-05 4.030846e-04 17 29611579 29611643 65 + 1.965 1.831 -0.448
ENSG00000198720 E022 108.9782105 0.0030712991 3.188945e-02 7.563993e-02 17 29611876 29612006 131 + 2.054 1.989 -0.216
ENSG00000198720 E023 119.4145022 0.0006734754 8.706437e-01 9.208399e-01 17 29612116 29612273 158 + 2.027 2.059 0.105
ENSG00000198720 E024 78.1090756 0.0003602722 7.620487e-01 8.457451e-01 17 29612402 29612463 62 + 1.857 1.870 0.043
ENSG00000198720 E025 79.2777901 0.0019596786 2.706313e-01 4.092624e-01 17 29612464 29612554 91 + 1.818 1.895 0.261
ENSG00000198720 E026 86.2283739 0.0004606377 5.561132e-01 6.848437e-01 17 29612652 29612815 164 + 1.908 1.910 0.008
ENSG00000198720 E027 55.9624732 0.0008580093 2.323835e-01 3.652716e-01 17 29612887 29612963 77 + 1.745 1.712 -0.113
ENSG00000198720 E028 35.3630150 0.0006738934 1.219307e-01 2.226684e-01 17 29612964 29613174 211 + 1.579 1.512 -0.230
ENSG00000198720 E029 90.2493047 0.0178945029 6.531716e-01 7.637180e-01 17 29613354 29613719 366 + 1.884 1.952 0.227
ENSG00000198720 E030 174.8170644 0.0060068705 3.610744e-05 2.103551e-04 17 29613720 29614262 543 + 2.064 2.279 0.719
ENSG00000198720 E031 142.4332435 0.0203350172 3.566113e-04 1.605820e-03 17 29614263 29614761 499 + 1.913 2.209 0.992