ENSG00000198668

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356978 ENSG00000198668 HEK293_OSMI2_2hA HEK293_TMG_2hB CALM1 protein_coding protein_coding 122.3567 84.61681 180.4261 6.817146 4.924928 1.092301 50.54888 51.238041 68.06600 5.936150 2.788308 0.4096494 0.45078750 0.60243333 0.3770667 -0.22536667 3.463774e-09 3.463774e-09 FALSE TRUE
ENST00000553995 ENSG00000198668 HEK293_OSMI2_2hA HEK293_TMG_2hB CALM1 protein_coding retained_intron 122.3567 84.61681 180.4261 6.817146 4.924928 1.092301 13.87091 1.777102 27.92465 1.402077 3.672320 3.9663620 0.09577917 0.02296667 0.1547333 0.13176667 1.807723e-01 3.463774e-09 FALSE TRUE
ENST00000557020 ENSG00000198668 HEK293_OSMI2_2hA HEK293_TMG_2hB CALM1 protein_coding protein_coding 122.3567 84.61681 180.4261 6.817146 4.924928 1.092301 52.00491 29.652149 74.47358 1.611200 4.012630 1.3282993 0.39497500 0.35183333 0.4124000 0.06056667 9.368445e-02 3.463774e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198668 E001 0.3686942 2.696120e-02 8.223598e-01 8.880113e-01 14 90396502 90396658 157 + 0.104 0.144 0.550
ENSG00000198668 E002 1.0769655 1.254129e-02 4.507364e-01 5.917907e-01 14 90397029 90397031 3 + 0.370 0.252 -0.776
ENSG00000198668 E003 59.2125914 1.312171e-02 4.374727e-07 3.914134e-06 14 90397032 90397039 8 + 1.904 1.544 -1.218
ENSG00000198668 E004 227.6867001 1.399659e-02 2.489531e-03 8.732672e-03 14 90397040 90397055 16 + 2.426 2.255 -0.571
ENSG00000198668 E005 424.1007915 1.218191e-02 3.912348e-03 1.289731e-02 14 90397056 90397154 99 + 2.685 2.542 -0.476
ENSG00000198668 E006 545.7031749 6.907675e-03 5.651102e-03 1.768859e-02 14 90397155 90397233 79 + 2.777 2.680 -0.324
ENSG00000198668 E007 1.5854202 1.429533e-02 8.735458e-01 9.227451e-01 14 90397692 90397858 167 + 0.418 0.410 -0.039
ENSG00000198668 E008 3.0152871 2.378532e-02 3.733630e-01 5.178092e-01 14 90397932 90398261 330 + 0.653 0.527 -0.566
ENSG00000198668 E009 11.7601194 1.889862e-03 3.011155e-01 4.428842e-01 14 90398262 90398451 190 + 1.135 1.065 -0.253
ENSG00000198668 E010 12.2655673 1.452656e-03 2.804537e-01 4.203114e-01 14 90398452 90398488 37 + 1.152 1.080 -0.261
ENSG00000198668 E011 18.6259733 1.531451e-02 3.651961e-04 1.639462e-03 14 90398489 90398990 502 + 1.411 1.067 -1.216
ENSG00000198668 E012 17.3032831 1.392601e-03 1.846683e-03 6.748284e-03 14 90398991 90399064 74 + 1.353 1.120 -0.821
ENSG00000198668 E013 14.5227180 1.170493e-03 1.201795e-02 3.357252e-02 14 90399065 90399087 23 + 1.273 1.079 -0.691
ENSG00000198668 E014 6.7310065 3.347101e-03 1.048371e-01 1.978557e-01 14 90399088 90399162 75 + 0.958 0.786 -0.660
ENSG00000198668 E015 18.5852785 1.007784e-03 9.882680e-08 1.004477e-06 14 90399163 90399977 815 + 1.433 1.002 -1.529
ENSG00000198668 E016 23.2297436 5.075052e-03 4.337740e-02 9.725387e-02 14 90399978 90400064 87 + 1.442 1.314 -0.442
ENSG00000198668 E017 583.0612272 2.820441e-03 4.070841e-04 1.801932e-03 14 90400065 90400095 31 + 2.799 2.720 -0.266
ENSG00000198668 E018 1.8604401 7.224399e-02 1.864058e-02 4.854426e-02 14 90400096 90400431 336 + 0.598 0.145 -2.907
ENSG00000198668 E019 874.4156415 5.843099e-04 1.995624e-09 2.793858e-08 14 90401259 90401332 74 + 2.972 2.903 -0.229
ENSG00000198668 E020 1054.7563351 1.185543e-04 5.559483e-08 5.929666e-07 14 90401333 90401402 70 + 3.038 3.008 -0.102
ENSG00000198668 E021 8.3103515 5.418182e-02 6.613703e-02 1.369415e-01 14 90401403 90401613 211 + 1.072 0.809 -0.989
ENSG00000198668 E022 8.8482024 1.289794e-02 2.874297e-01 4.279223e-01 14 90403632 90403861 230 + 1.040 0.946 -0.349
ENSG00000198668 E023 1351.9884213 1.105595e-04 7.048309e-03 2.135015e-02 14 90403862 90403968 107 + 3.131 3.135 0.016
ENSG00000198668 E024 5.5359262 3.024059e-03 1.182662e-02 3.311680e-02 14 90403969 90404153 185 + 0.931 0.618 -1.261
ENSG00000198668 E025 5.4164737 6.063505e-03 1.914552e-01 3.155696e-01 14 90404168 90404378 211 + 0.873 0.726 -0.580
ENSG00000198668 E026 842.0618429 1.398358e-04 4.791305e-01 6.175229e-01 14 90404379 90404398 20 + 2.908 2.950 0.138
ENSG00000198668 E027 1399.2073075 8.162946e-05 8.660937e-06 5.836820e-05 14 90404399 90404514 116 + 3.112 3.188 0.253
ENSG00000198668 E028 5576.0464673 3.809942e-03 9.717756e-05 5.088305e-04 14 90404689 90408268 3580 + 3.697 3.796 0.328