ENSG00000198642

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359039 ENSG00000198642 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL9 protein_coding protein_coding 13.46292 6.701006 21.12027 0.3121312 0.244339 1.65471 0.7929791 0.27835940 1.6395260 0.05958901 0.19237527 2.516112 0.05024167 0.040966667 0.07743333 0.03646667 1.325567e-01 2.64019e-26 FALSE TRUE
MSTRG.32460.1 ENSG00000198642 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL9 protein_coding   13.46292 6.701006 21.12027 0.3121312 0.244339 1.65471 1.5473597 0.04017167 3.2529114 0.02115323 0.18731957 6.023143 0.07372500 0.005766667 0.15426667 0.14850000 3.108815e-15 2.64019e-26 TRUE TRUE
MSTRG.32460.3 ENSG00000198642 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL9 protein_coding   13.46292 6.701006 21.12027 0.3121312 0.244339 1.65471 1.3135197 2.00805362 0.9672721 0.14861563 0.05843042 -1.046132 0.16465417 0.299566667 0.04576667 -0.25380000 2.640190e-26 2.64019e-26   FALSE
MSTRG.32460.5 ENSG00000198642 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL9 protein_coding   13.46292 6.701006 21.12027 0.3121312 0.244339 1.65471 0.2233843 0.78891677 0.1038269 0.47636087 0.10382691 -2.811204 0.03256250 0.116866667 0.00490000 -0.11196667 3.022921e-01 2.64019e-26   FALSE
MSTRG.32460.6 ENSG00000198642 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL9 protein_coding   13.46292 6.701006 21.12027 0.3121312 0.244339 1.65471 8.7312266 3.03665380 14.0524412 0.29035865 0.20414957 2.206550 0.59384167 0.451266667 0.66530000 0.21403333 3.085955e-07 2.64019e-26 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198642 E001 2.018850 0.0721398363 6.306748e-01 7.458236e-01 9 21319378 21319481 104 - 0.448 0.361 -0.479
ENSG00000198642 E002 1.102863 0.3905681673 8.497315e-01 9.067534e-01 9 21319482 21319482 1 - 0.297 0.220 -0.574
ENSG00000198642 E003 1.254378 0.1574669164 6.000074e-01 7.213042e-01 9 21319483 21319556 74 - 0.333 0.218 -0.821
ENSG00000198642 E004 8.166149 0.0020833818 3.915711e-01 5.354862e-01 9 21321314 21321532 219 - 0.916 0.832 -0.320
ENSG00000198642 E005 3.873073 0.0041075283 8.312562e-01 8.942099e-01 9 21321533 21321553 21 - 0.632 0.625 -0.030
ENSG00000198642 E006 5.195320 0.0038614515 5.551923e-01 6.840722e-01 9 21321554 21321633 80 - 0.749 0.687 -0.253
ENSG00000198642 E007 23.742112 0.0008084751 1.966153e-25 2.242515e-23 9 21324076 21324130 55 - 0.995 1.770 2.705
ENSG00000198642 E008 59.709756 0.0004116710 5.525320e-55 4.591032e-52 9 21324131 21324321 191 - 1.401 2.148 2.530
ENSG00000198642 E009 15.877029 0.0011832558 1.579723e-07 1.544160e-06 9 21329331 21329415 85 - 0.988 1.477 1.733
ENSG00000198642 E010 4.654088 0.0034044978 5.010906e-04 2.164065e-03 9 21329416 21329419 4 - 0.519 1.027 2.068
ENSG00000198642 E011 19.503835 0.0011361507 5.663961e-01 6.933807e-01 9 21329665 21330793 1129 - 1.250 1.233 -0.060
ENSG00000198642 E012 21.454762 0.0012645791 3.278448e-12 7.394834e-11 9 21330794 21330913 120 - 1.068 1.632 1.970
ENSG00000198642 E013 523.998030 0.0056816296 6.349129e-03 1.953143e-02 9 21330914 21332905 1992 - 2.621 2.735 0.376
ENSG00000198642 E014 715.980899 0.0002576926 1.548059e-108 5.750493e-105 9 21332906 21335096 2191 - 2.837 2.552 -0.948
ENSG00000198642 E015 112.341961 0.0033372488 4.628135e-13 1.199434e-11 9 21335097 21335472 376 - 1.877 2.216 1.139