ENSG00000198625

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367182 ENSG00000198625 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM4 protein_coding protein_coding 6.050117 4.053778 4.817368 0.06879515 0.05982641 0.2484155 0.92798394 0.41636093 0.33714151 0.22179583 0.22162221 -0.29655135 0.16539167 0.102800000 0.06970000 -0.03310000 0.9223129863 0.0002178528 FALSE TRUE
ENST00000367183 ENSG00000198625 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM4 protein_coding protein_coding 6.050117 4.053778 4.817368 0.06879515 0.05982641 0.2484155 0.27632425 0.74994308 0.00000000 0.37599981 0.00000000 -6.24781946 0.05891250 0.186466667 0.00000000 -0.18646667 0.1356665424 0.0002178528 FALSE TRUE
ENST00000391947 ENSG00000198625 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM4 protein_coding protein_coding 6.050117 4.053778 4.817368 0.06879515 0.05982641 0.2484155 1.78141767 0.97344892 2.73216392 0.34496787 0.24084630 1.47939278 0.31401250 0.239566667 0.56846667 0.32890000 0.0298512183 0.0002178528 TRUE FALSE
ENST00000444261 ENSG00000198625 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM4 protein_coding protein_coding 6.050117 4.053778 4.817368 0.06879515 0.05982641 0.2484155 1.10622527 1.27928193 0.05102519 0.25293404 0.05102519 -4.40101901 0.15246667 0.314800000 0.01043333 -0.30436667 0.0002178528 0.0002178528 FALSE FALSE
ENST00000454264 ENSG00000198625 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM4 protein_coding protein_coding 6.050117 4.053778 4.817368 0.06879515 0.05982641 0.2484155 0.09121035 0.00000000 0.31011876 0.00000000 0.31011876 5.00053532 0.01645417 0.000000000 0.06370000 0.06370000 0.8556522923 0.0002178528 FALSE TRUE
ENST00000462012 ENSG00000198625 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM4 protein_coding processed_transcript 6.050117 4.053778 4.817368 0.06879515 0.05982641 0.2484155 0.65378863 0.27517294 0.27228856 0.09479555 0.05377302 -0.01466638 0.09329583 0.068566667 0.05643333 -0.01213333 0.9405647601 0.0002178528 FALSE FALSE
ENST00000470797 ENSG00000198625 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM4 protein_coding processed_transcript 6.050117 4.053778 4.817368 0.06879515 0.05982641 0.2484155 0.18459974 0.03796695 0.31543495 0.02071287 0.03893579 2.76225664 0.02879167 0.009233333 0.06533333 0.05610000 0.0032423410 0.0002178528 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198625 E001 0.0000000       1 204516379 204516382 4 +      
ENSG00000198625 E002 0.8157519 0.0159434314 7.437286e-01 8.322926e-01 1 204516383 204516405 23 + 0.261 0.248 -0.096
ENSG00000198625 E003 1.4091281 0.0095288660 1.232689e-01 2.246359e-01 1 204516406 204516411 6 + 0.466 0.248 -1.318
ENSG00000198625 E004 4.1330256 0.0245416093 5.446881e-02 1.170772e-01 1 204516412 204516419 8 + 0.794 0.569 -0.947
ENSG00000198625 E005 9.1445630 0.0039819026 1.462976e-04 7.311472e-04 1 204516420 204516450 31 + 1.126 0.779 -1.300
ENSG00000198625 E006 9.8024818 0.0021683030 1.621367e-03 6.029547e-03 1 204516451 204516471 21 + 1.126 0.878 -0.914
ENSG00000198625 E007 11.1729132 0.0015525135 1.118814e-03 4.366356e-03 1 204516472 204516504 33 + 1.176 0.940 -0.861
ENSG00000198625 E008 9.2303358 0.0018212356 2.632632e-02 6.460167e-02 1 204516505 204516509 5 + 1.069 0.920 -0.548
ENSG00000198625 E009 9.2774530 0.0018106606 4.123870e-03 1.348875e-02 1 204525484 204525489 6 + 1.098 0.878 -0.816
ENSG00000198625 E010 10.0943507 0.0017243466 1.930358e-03 7.009787e-03 1 204525490 204525518 29 + 1.135 0.900 -0.864
ENSG00000198625 E011 14.7554530 0.0012687143 8.212565e-05 4.380320e-04 1 204525519 204525596 78 + 1.300 1.042 -0.919
ENSG00000198625 E012 13.4129980 0.0330566899 3.125080e-04 1.430628e-03 1 204526360 204526434 75 + 1.294 0.920 -1.350
ENSG00000198625 E013 19.3713659 0.0050743942 1.725681e-06 1.361281e-05 1 204530684 204530817 134 + 1.429 1.112 -1.113
ENSG00000198625 E014 12.8585848 0.0053818215 5.807315e-05 3.220097e-04 1 204532191 204532246 56 + 1.256 0.940 -1.143
ENSG00000198625 E015 2.3251150 0.0063807982 2.959121e-02 7.115524e-02 1 204532247 204532650 404 + 0.633 0.334 -1.511
ENSG00000198625 E016 1.0675023 0.0116580276 6.693932e-02 1.382853e-01 1 204532769 204532819 51 + 0.423 0.142 -2.096
ENSG00000198625 E017 2.4787304 0.3078337705 7.089242e-01 8.064537e-01 1 204536918 204537041 124 + 0.543 0.528 -0.070
ENSG00000198625 E018 3.1588603 0.1043739678 9.292592e-01 9.595129e-01 1 204537430 204537458 29 + 0.575 0.652 0.341
ENSG00000198625 E019 4.9774953 0.0805710249 5.422599e-01 6.730421e-01 1 204537459 204537497 39 + 0.795 0.749 -0.182
ENSG00000198625 E020 1.5092468 0.0088826018 8.652204e-01 9.171674e-01 1 204537857 204537874 18 + 0.375 0.405 0.169
ENSG00000198625 E021 3.3926002 0.0405203189 5.861626e-01 7.097725e-01 1 204537875 204537991 117 + 0.633 0.615 -0.078
ENSG00000198625 E022 2.4753802 0.0060908468 3.346880e-01 4.784248e-01 1 204537992 204538208 217 + 0.423 0.650 1.073
ENSG00000198625 E023 8.9396306 0.0238591807 1.549665e-03 5.796807e-03 1 204538209 204538220 12 + 1.117 0.780 -1.269
ENSG00000198625 E024 18.4923761 0.0011559513 5.020229e-05 2.828249e-04 1 204538221 204538308 88 + 1.382 1.149 -0.816
ENSG00000198625 E025 10.4168873 0.0017194513 3.963908e-03 1.304254e-02 1 204542784 204542788 5 + 1.143 0.940 -0.744
ENSG00000198625 E026 24.2635693 0.0041833732 3.687541e-03 1.225990e-02 1 204542789 204542944 156 + 1.454 1.331 -0.427
ENSG00000198625 E027 25.3304124 0.0040446932 2.423234e-02 6.029109e-02 1 204544535 204544684 150 + 1.454 1.388 -0.227
ENSG00000198625 E028 24.7012253 0.0007604709 6.809964e-03 2.072827e-02 1 204546797 204546877 81 + 1.450 1.361 -0.308
ENSG00000198625 E029 33.5415754 0.0086635562 6.358031e-04 2.665494e-03 1 204549113 204549265 153 + 1.605 1.446 -0.543
ENSG00000198625 E030 865.9310722 0.0026544448 1.562016e-29 2.507791e-27 1 204549266 204558120 8855 + 2.834 3.033 0.660