ENSG00000198612

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392008 ENSG00000198612 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS8 protein_coding protein_coding 66.85384 51.04667 94.9165 7.169635 1.530516 0.8947115 20.75067 18.82938 22.61940 2.729107 1.2668568 0.2644463 0.3202042 0.3707000 0.2380000 -0.13270000 0.004035203 0.001188533 FALSE TRUE
ENST00000409334 ENSG00000198612 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS8 protein_coding protein_coding 66.85384 51.04667 94.9165 7.169635 1.530516 0.8947115 12.80661 12.46932 17.43794 3.190168 0.6723934 0.4835176 0.1985292 0.2367667 0.1837333 -0.05303333 0.386558156 0.001188533 FALSE TRUE
MSTRG.20124.5 ENSG00000198612 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS8 protein_coding   66.85384 51.04667 94.9165 7.169635 1.530516 0.8947115 30.40011 18.85887 49.97275 1.819726 0.9536683 1.4054226 0.4398292 0.3749667 0.5266667 0.15170000 0.003660319 0.001188533 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198612 E001 0.8105550 0.0149599229 3.478257e-01 4.920330e-01 2 237085882 237085883 2 + 0.307 0.150 -1.321
ENSG00000198612 E002 0.8105550 0.0149599229 3.478257e-01 4.920330e-01 2 237085884 237085885 2 + 0.307 0.150 -1.321
ENSG00000198612 E003 0.8105550 0.0149599229 3.478257e-01 4.920330e-01 2 237085886 237085888 3 + 0.307 0.150 -1.321
ENSG00000198612 E004 0.6653823 0.0170899775 5.401173e-01 6.713089e-01 2 237085889 237085890 2 + 0.248 0.150 -0.906
ENSG00000198612 E005 24.3954012 0.0007994560 4.255878e-05 2.438125e-04 2 237085891 237085908 18 + 1.504 1.231 -0.945
ENSG00000198612 E006 316.5804441 0.0001679580 1.179170e-08 1.434840e-07 2 237085909 237086042 134 + 2.538 2.451 -0.288
ENSG00000198612 E007 10.8136466 0.0016333964 1.046632e-03 4.120389e-03 2 237086732 237086796 65 + 1.181 0.856 -1.197
ENSG00000198612 E008 347.0749496 0.0001637078 1.671744e-06 1.322367e-05 2 237087127 237087197 71 + 2.569 2.506 -0.210
ENSG00000198612 E009 2.0755572 0.0068918276 5.287846e-03 1.671561e-02 2 237087464 237087563 100 + 0.638 0.150 -3.024
ENSG00000198612 E010 329.7872138 0.0001539368 1.212944e-05 7.904119e-05 2 237088605 237088653 49 + 2.544 2.488 -0.188
ENSG00000198612 E011 554.5635460 0.0001280708 2.550605e-03 8.914061e-03 2 237089862 237089994 133 + 2.752 2.737 -0.052
ENSG00000198612 E012 5.8054557 0.0034737814 1.971285e-01 3.226412e-01 2 237093663 237094089 427 + 0.886 0.742 -0.564
ENSG00000198612 E013 406.9039376 0.0003059151 6.196603e-01 7.369937e-01 2 237094090 237094138 49 + 2.594 2.632 0.126
ENSG00000198612 E014 444.3719311 0.0006949387 5.891028e-01 7.121947e-01 2 237094139 237094197 59 + 2.642 2.657 0.050
ENSG00000198612 E015 437.8774136 0.0001403694 5.720030e-01 6.981802e-01 2 237095822 237095884 63 + 2.627 2.667 0.133
ENSG00000198612 E016 1.0478208 0.2773849893 6.131882e-01 7.319521e-01 2 237096678 237096821 144 + 0.360 0.255 -0.692
ENSG00000198612 E017 396.0511094 0.0001621583 6.222084e-01 7.390361e-01 2 237096822 237096869 48 + 2.592 2.614 0.072
ENSG00000198612 E018 499.7376502 0.0001554526 1.218380e-01 2.225433e-01 2 237097663 237097802 140 + 2.676 2.731 0.182
ENSG00000198612 E019 1306.1876977 0.0027463012 2.974921e-08 3.351311e-07 2 237097803 237098957 1155 + 3.046 3.190 0.478
ENSG00000198612 E020 18.1310027 0.0009881810 3.034579e-09 4.112833e-08 2 237098958 237099038 81 + 1.435 0.924 -1.826
ENSG00000198612 E021 79.4342687 0.0082079046 2.223313e-12 5.156710e-11 2 237099039 237100474 1436 + 2.037 1.618 -1.414
ENSG00000198612 E022 0.2214452 0.0503666787 3.252267e-01   2 237126999 237127051 53 + 0.000 0.150 9.742