ENSG00000198604

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358716 ENSG00000198604 HEK293_OSMI2_2hA HEK293_TMG_2hB BAZ1A protein_coding protein_coding 19.90695 7.347034 36.12068 0.391217 1.014855 2.296028 2.1420489 0.4687055 4.419311 0.08454626 0.1849610 3.2098720 0.09110000 0.0634000 0.1228333 0.05943333 1.613656e-02 2.005309e-39 FALSE TRUE
ENST00000382422 ENSG00000198604 HEK293_OSMI2_2hA HEK293_TMG_2hB BAZ1A protein_coding protein_coding 19.90695 7.347034 36.12068 0.391217 1.014855 2.296028 7.6951951 5.3438097 9.744172 0.11840585 1.1061369 0.8654535 0.47065417 0.7335333 0.2685000 -0.46503333 2.699758e-06 2.005309e-39 FALSE TRUE
ENST00000555331 ENSG00000198604 HEK293_OSMI2_2hA HEK293_TMG_2hB BAZ1A protein_coding nonsense_mediated_decay 19.90695 7.347034 36.12068 0.391217 1.014855 2.296028 0.9201685 0.8901527 1.080760 0.44568903 0.9097777 0.2770922 0.08238333 0.1150333 0.0314000 -0.08363333 6.948239e-01 2.005309e-39   FALSE
MSTRG.9366.5 ENSG00000198604 HEK293_OSMI2_2hA HEK293_TMG_2hB BAZ1A protein_coding   19.90695 7.347034 36.12068 0.391217 1.014855 2.296028 6.2849332 0.0000000 15.421003 0.00000000 0.4112484 10.5916161 0.21684583 0.0000000 0.4283000 0.42830000 2.005309e-39 2.005309e-39 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198604 E001 0.8146179 0.1571475755 6.718775e-04 2.795745e-03 14 34752731 34752731 1 - 0.000 0.632 15.709
ENSG00000198604 E002 193.7435675 0.0121930781 2.196006e-14 6.868528e-13 14 34752732 34753233 502 - 2.057 2.522 1.553
ENSG00000198604 E003 124.7811207 0.0002868243 6.038300e-18 3.037540e-16 14 34753234 34753348 115 - 1.932 2.240 1.033
ENSG00000198604 E004 56.5313752 0.0004659087 5.098463e-08 5.486756e-07 14 34753349 34753355 7 - 1.600 1.889 0.976
ENSG00000198604 E005 73.8740431 0.0004024922 4.046314e-06 2.939272e-05 14 34753356 34753365 10 - 1.737 1.958 0.747
ENSG00000198604 E006 265.2976402 0.0021685970 4.327782e-12 9.558001e-11 14 34753366 34753704 339 - 2.281 2.513 0.773
ENSG00000198604 E007 157.7233183 0.0002205229 8.657128e-04 3.493369e-03 14 34754827 34754914 88 - 2.091 2.209 0.397
ENSG00000198604 E008 0.1451727 0.0429709483 1.000000e+00   14 34758566 34758703 138 - 0.064 0.000 -9.727
ENSG00000198604 E009 173.4899718 0.0005269380 3.481702e-04 1.572793e-03 14 34758704 34758846 143 - 2.132 2.257 0.417
ENSG00000198604 E010 228.9469909 0.0002081325 8.719255e-04 3.515968e-03 14 34761757 34762026 270 - 2.258 2.358 0.336
ENSG00000198604 E011 241.5020839 0.0002030378 5.212267e-02 1.129416e-01 14 34762027 34762223 197 - 2.290 2.352 0.206
ENSG00000198604 E012 264.5174908 0.0001959087 5.328738e-01 6.651688e-01 14 34764707 34764881 175 - 2.338 2.364 0.085
ENSG00000198604 E013 145.1996462 0.0002609763 4.986641e-01 6.351140e-01 14 34764882 34764933 52 - 2.089 2.073 -0.051
ENSG00000198604 E014 251.2343506 0.0002104412 9.043740e-01 9.430992e-01 14 34765021 34765268 248 - 2.318 2.324 0.019
ENSG00000198604 E015 0.1451727 0.0429709483 1.000000e+00   14 34768690 34768780 91 - 0.064 0.000 -9.727
ENSG00000198604 E016 0.4804688 0.0215920111 5.473638e-01 6.774180e-01 14 34771175 34771510 336 - 0.119 0.223 1.086
ENSG00000198604 E017 174.7789469 0.0002061391 6.264654e-02 1.310969e-01 14 34771511 34771659 149 - 2.175 2.122 -0.179
ENSG00000198604 E018 196.2714056 0.0002242155 4.234425e-02 9.535118e-02 14 34773572 34773726 155 - 2.226 2.170 -0.186
ENSG00000198604 E019 185.3719511 0.0002421709 3.765250e-03 1.248287e-02 14 34774327 34774490 164 - 2.207 2.120 -0.292
ENSG00000198604 E020 199.4028844 0.0122078317 8.939233e-02 1.742008e-01 14 34775919 34776189 271 - 2.240 2.147 -0.314
ENSG00000198604 E021 250.4561594 0.0022017157 3.347522e-07 3.066476e-06 14 34776190 34776515 326 - 2.353 2.173 -0.604
ENSG00000198604 E022 3.4793972 0.0045132452 1.717543e-01 2.904923e-01 14 34780116 34780176 61 - 0.528 0.755 0.986
ENSG00000198604 E023 3.5254939 0.0450448723 2.028132e-01 3.297462e-01 14 34780177 34780185 9 - 0.528 0.756 0.988
ENSG00000198604 E024 160.6641899 0.0002315776 1.212464e-06 9.891383e-06 14 34780186 34780310 125 - 2.160 1.989 -0.572
ENSG00000198604 E025 154.6448437 0.0002319770 5.541205e-07 4.861372e-06 14 34783119 34783232 114 - 2.146 1.965 -0.606
ENSG00000198604 E026 143.9654168 0.0002538924 2.849369e-04 1.318590e-03 14 34783762 34783895 134 - 2.107 1.977 -0.436
ENSG00000198604 E027 73.9941475 0.0005230778 5.425054e-02 1.166875e-01 14 34783896 34783927 32 - 1.814 1.721 -0.312
ENSG00000198604 E028 162.7092306 0.0004660950 5.161256e-01 6.506980e-01 14 34785777 34786001 225 - 2.136 2.122 -0.047
ENSG00000198604 E029 0.8920389 0.0143468688 4.280778e-01 5.708920e-01 14 34786002 34786091 90 - 0.213 0.369 1.083
ENSG00000198604 E030 77.5936327 0.0010105602 3.144528e-01 4.571641e-01 14 34786126 34786221 96 - 1.803 1.862 0.198
ENSG00000198604 E031 4.1394730 0.0039479515 2.162882e-01 3.459396e-01 14 34786222 34786601 380 - 0.694 0.479 -0.974
ENSG00000198604 E032 137.0530461 0.0002351794 1.352360e-02 3.713482e-02 14 34792775 34792921 147 - 2.038 2.135 0.324
ENSG00000198604 E033 138.0711199 0.0004136469 2.905789e-03 9.986630e-03 14 34794749 34794887 139 - 2.036 2.152 0.386
ENSG00000198604 E034 95.5855746 0.0055732813 5.513833e-02 1.182346e-01 14 34795670 34795765 96 - 1.879 1.993 0.383
ENSG00000198604 E035 85.5933971 0.0076580147 6.677267e-01 7.748826e-01 14 34800224 34800390 167 - 1.864 1.847 -0.059
ENSG00000198604 E036 94.3659277 0.0003628683 4.681866e-05 2.656540e-04 14 34801094 34801193 100 - 1.937 1.748 -0.636
ENSG00000198604 E037 123.7288299 0.0002854600 2.910106e-09 3.959713e-08 14 34802854 34802988 135 - 2.062 1.811 -0.844
ENSG00000198604 E038 96.2689973 0.0042099348 4.044171e-05 2.327963e-04 14 34807451 34807538 88 - 1.950 1.716 -0.788
ENSG00000198604 E039 57.9927207 0.0110312299 2.228515e-03 7.931048e-03 14 34810935 34810941 7 - 1.734 1.486 -0.845
ENSG00000198604 E040 95.3324584 0.0072804611 3.260248e-03 1.103310e-02 14 34810942 34811036 95 - 1.938 1.754 -0.618
ENSG00000198604 E041 0.0000000       14 34816715 34816856 142 -      
ENSG00000198604 E042 103.2947343 0.0051484700 6.215743e-04 2.612201e-03 14 34826013 34826156 144 - 1.975 1.783 -0.648
ENSG00000198604 E043 0.2214452 0.0408236750 1.010313e-01   14 34828559 34828723 165 - 0.000 0.223 13.628
ENSG00000198604 E044 146.6194076 0.0028902079 6.341185e-12 1.363585e-10 14 34862044 34862322 279 - 2.144 1.811 -1.119
ENSG00000198604 E045 95.0691374 0.0112260865 5.703955e-08 6.070770e-07 14 34874492 34874662 171 - 1.966 1.556 -1.387
ENSG00000198604 E046 5.0242148 0.0031850495 2.560783e-04 1.200615e-03 14 34874663 34874868 206 - 0.804 0.000 -14.814
ENSG00000198604 E047 2.3679789 0.0060972578 1.355285e-01 2.418540e-01 14 34874869 34875008 140 - 0.528 0.223 -1.821
ENSG00000198604 E048 57.3551593 0.0136577524 3.944388e-05 2.276890e-04 14 34875138 34876457 1320 - 1.743 1.380 -1.241