ENSG00000198554

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360586 ENSG00000198554 HEK293_OSMI2_2hA HEK293_TMG_2hB WDHD1 protein_coding protein_coding 12.86996 3.354203 17.98585 0.4693307 0.4427764 2.419327 3.1456836 1.2905552 4.4308041 0.2106855 0.1989831 1.771693 0.28490833 0.42360000 0.2462333 -0.1773667 0.50286975 0.01685942 FALSE TRUE
ENST00000420358 ENSG00000198554 HEK293_OSMI2_2hA HEK293_TMG_2hB WDHD1 protein_coding protein_coding 12.86996 3.354203 17.98585 0.4693307 0.4427764 2.419327 2.8075171 0.8515760 3.6807067 0.1498239 0.3022762 2.098847 0.19238333 0.25340000 0.2054000 -0.0480000 0.57321305 0.01685942 FALSE TRUE
ENST00000475379 ENSG00000198554 HEK293_OSMI2_2hA HEK293_TMG_2hB WDHD1 protein_coding retained_intron 12.86996 3.354203 17.98585 0.4693307 0.4427764 2.419327 0.3874468 0.9844013 0.0000000 0.4949890 0.0000000 -6.635756 0.07495417 0.25843333 0.0000000 -0.2584333 0.04739887 0.01685942 FALSE TRUE
ENST00000567693 ENSG00000198554 HEK293_OSMI2_2hA HEK293_TMG_2hB WDHD1 protein_coding nonsense_mediated_decay 12.86996 3.354203 17.98585 0.4693307 0.4427764 2.419327 0.5792614 0.0000000 0.3474137 0.0000000 0.3474137 5.159523 0.10083333 0.00000000 0.0184000 0.0184000 1.00000000 0.01685942 FALSE TRUE
MSTRG.9577.4 ENSG00000198554 HEK293_OSMI2_2hA HEK293_TMG_2hB WDHD1 protein_coding   12.86996 3.354203 17.98585 0.4693307 0.4427764 2.419327 5.5339935 0.1856131 8.4846334 0.1856131 0.1969121 5.440477 0.31687083 0.04723333 0.4720333 0.4248000 0.01685942 0.01685942 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198554 E001 141.8416222 0.0138544963 1.563650e-06 1.244972e-05 14 54938949 54941158 2210 - 1.957 2.290 1.113
ENSG00000198554 E002 19.6835847 0.0020850761 1.948917e-02 5.039045e-02 14 54941159 54941175 17 - 1.156 1.391 0.825
ENSG00000198554 E003 36.4990954 0.0008308929 9.868422e-09 1.218340e-07 14 54941176 54941270 95 - 1.363 1.755 1.341
ENSG00000198554 E004 30.3229010 0.0007028771 1.028789e-18 5.677280e-17 14 54941271 54941326 56 - 1.198 1.806 2.090
ENSG00000198554 E005 135.4142476 0.0002982020 4.396111e-18 2.238189e-16 14 54941327 54941690 364 - 1.939 2.260 1.077
ENSG00000198554 E006 91.6442926 0.0004053966 2.771209e-05 1.661485e-04 14 54944332 54944470 139 - 1.800 2.008 0.698
ENSG00000198554 E007 0.1515154 0.0429102801 1.000000e+00   14 54944471 54944607 137 - 0.055 0.001 -5.748
ENSG00000198554 E008 76.1868563 0.0007361932 1.308785e-04 6.626413e-04 14 54955561 54955694 134 - 1.721 1.931 0.707
ENSG00000198554 E009 86.7668665 0.0013651060 1.747913e-01 2.944336e-01 14 54957034 54957204 171 - 1.805 1.893 0.298
ENSG00000198554 E010 48.8761507 0.0004794838 9.525082e-01 9.742722e-01 14 54957592 54957629 38 - 1.573 1.598 0.082
ENSG00000198554 E011 33.3103226 0.0006472107 7.255318e-01 8.187678e-01 14 54957630 54957635 6 - 1.408 1.456 0.163
ENSG00000198554 E012 50.1397809 0.0004558357 8.586297e-01 9.127925e-01 14 54962498 54962551 54 - 1.589 1.597 0.030
ENSG00000198554 E013 66.1442066 0.0003678983 8.089171e-01 8.786540e-01 14 54962738 54962853 116 - 1.704 1.711 0.022
ENSG00000198554 E014 93.9167022 0.0004071861 1.474756e-02 3.992114e-02 14 54962952 54963172 221 - 1.872 1.767 -0.353
ENSG00000198554 E015 61.7486653 0.0004372363 1.698291e-01 2.879946e-01 14 54966475 54966606 132 - 1.687 1.623 -0.218
ENSG00000198554 E016 52.9031164 0.0006290068 1.312255e-01 2.358584e-01 14 54967280 54967394 115 - 1.623 1.542 -0.277
ENSG00000198554 E017 71.7635019 0.0003748178 2.750098e-02 6.700765e-02 14 54981540 54981696 157 - 1.755 1.647 -0.369
ENSG00000198554 E018 71.0420146 0.0003398718 3.012429e-04 1.384747e-03 14 54984723 54984860 138 - 1.765 1.562 -0.690
ENSG00000198554 E019 102.2860785 0.0003158233 9.417163e-03 2.732464e-02 14 54987146 54987387 242 - 1.908 1.801 -0.361
ENSG00000198554 E020 88.4654940 0.0003946175 4.267267e-01 5.695432e-01 14 54989028 54989212 185 - 1.831 1.812 -0.067
ENSG00000198554 E021 82.3433309 0.0004565463 1.728563e-01 2.919149e-01 14 54991213 54991400 188 - 1.808 1.755 -0.177
ENSG00000198554 E022 88.1521708 0.0003098270 6.834554e-02 1.406397e-01 14 54995603 54995813 211 - 1.841 1.767 -0.249
ENSG00000198554 E023 79.4639107 0.0007549434 2.824166e-02 6.848867e-02 14 55000503 55000644 142 - 1.800 1.697 -0.348
ENSG00000198554 E024 58.7160406 0.0004265397 8.226435e-03 2.435862e-02 14 55000886 55000992 107 - 1.677 1.522 -0.527
ENSG00000198554 E025 53.7302469 0.0004567487 1.650631e-03 6.123227e-03 14 55002093 55002185 93 - 1.646 1.444 -0.694
ENSG00000198554 E026 61.6575375 0.0003935815 2.292393e-04 1.088793e-03 14 55007280 55007375 96 - 1.707 1.479 -0.776
ENSG00000198554 E027 46.2175207 0.0013519924 2.635143e-04 1.230970e-03 14 55008316 55008366 51 - 1.590 1.316 -0.946
ENSG00000198554 E028 58.1819511 0.0004576522 5.771783e-03 1.801336e-02 14 55008608 55008719 112 - 1.676 1.512 -0.559
ENSG00000198554 E029 72.5952316 0.0003285846 1.185957e-02 3.319484e-02 14 55010309 55010460 152 - 1.766 1.639 -0.430
ENSG00000198554 E030 73.6447570 0.0003796782 4.680305e-04 2.037900e-03 14 55013485 55013596 112 - 1.779 1.589 -0.647
ENSG00000198554 E031 66.7454100 0.0003545280 2.979154e-06 2.230621e-05 14 55026711 55026799 89 - 1.748 1.456 -0.997
ENSG00000198554 E032 38.4841936 0.0005155301 8.403237e-06 5.680326e-05 14 55026800 55026803 4 - 1.524 1.133 -1.363
ENSG00000198554 E033 2.6456388 0.0224062209 2.135564e-01 3.427188e-01 14 55026804 55027027 224 - 0.516 0.252 -1.539
ENSG00000198554 E034 39.6209484 0.0005452656 1.361520e-06 1.098488e-05 14 55027028 55027105 78 - 1.538 1.108 -1.503