ENSG00000198498

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358572 ENSG00000198498 HEK293_OSMI2_2hA HEK293_TMG_2hB TMA16 protein_coding protein_coding 27.1066 18.29603 37.48787 1.208653 1.685843 1.03449 11.743678 10.7416941 17.405886 1.7143231 2.0940292 0.6958399 0.44200417 0.58380000 0.46136667 -0.12243333 0.4266785752 0.0004190432 FALSE TRUE
ENST00000508268 ENSG00000198498 HEK293_OSMI2_2hA HEK293_TMG_2hB TMA16 protein_coding protein_coding 27.1066 18.29603 37.48787 1.208653 1.685843 1.03449 2.475692 1.6028304 2.350261 0.9382681 0.7768230 0.5493517 0.12471250 0.09050000 0.06483333 -0.02566667 0.9916517289 0.0004190432 FALSE TRUE
ENST00000509657 ENSG00000198498 HEK293_OSMI2_2hA HEK293_TMG_2hB TMA16 protein_coding protein_coding 27.1066 18.29603 37.48787 1.208653 1.685843 1.03449 1.699090 0.1675418 1.766824 0.1675418 0.8885159 3.3230696 0.05045000 0.00900000 0.04863333 0.03963333 0.5733228401 0.0004190432 FALSE TRUE
ENST00000511562 ENSG00000198498 HEK293_OSMI2_2hA HEK293_TMG_2hB TMA16 protein_coding processed_transcript 27.1066 18.29603 37.48787 1.208653 1.685843 1.03449 2.009474 1.6772404 2.078444 0.1502709 0.4329576 0.3077629 0.07360833 0.09206667 0.05526667 -0.03680000 0.1770238140 0.0004190432   FALSE
ENST00000513272 ENSG00000198498 HEK293_OSMI2_2hA HEK293_TMG_2hB TMA16 protein_coding protein_coding 27.1066 18.29603 37.48787 1.208653 1.685843 1.03449 8.271964 3.8857761 12.535144 0.3589772 0.8699123 1.6871463 0.27697917 0.21263333 0.33366667 0.12103333 0.0004190432 0.0004190432   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198498 E001 1.2772056 0.4704999982 0.8971678000 0.938329943 4 163494442 163494559 118 + 0.357 0.353 -0.020
ENSG00000198498 E002 4.6728286 0.0035826072 0.5671989905 0.694040634 4 163494659 163494666 8 + 0.786 0.711 -0.305
ENSG00000198498 E003 4.8180013 0.0038230499 0.4815816237 0.619786082 4 163494667 163494667 1 + 0.804 0.711 -0.375
ENSG00000198498 E004 25.7606458 0.0027473121 0.5844354197 0.708378355 4 163494668 163494687 20 + 1.441 1.405 -0.123
ENSG00000198498 E005 25.9058185 0.0025659341 0.5445676988 0.675015813 4 163494688 163494689 2 + 1.445 1.405 -0.137
ENSG00000198498 E006 71.8819334 0.0013205449 0.1525190895 0.265107063 4 163494690 163494707 18 + 1.883 1.822 -0.206
ENSG00000198498 E007 152.4890021 0.0003575032 0.6248168998 0.741056446 4 163494708 163494804 97 + 2.176 2.194 0.061
ENSG00000198498 E008 5.5066782 0.0029159774 0.3946747877 0.538513843 4 163494805 163494836 32 + 0.854 0.745 -0.430
ENSG00000198498 E009 223.7926385 0.0008755003 0.2390412568 0.372997290 4 163507033 163507145 113 + 2.334 2.367 0.108
ENSG00000198498 E010 1.5781470 0.0089986027 0.5847430421 0.708596261 4 163512424 163512821 398 + 0.446 0.351 -0.526
ENSG00000198498 E011 135.2937648 0.0002403013 0.0727482816 0.147922547 4 163512822 163512859 38 + 2.109 2.168 0.195
ENSG00000198498 E012 183.0020611 0.0003149755 0.8521332676 0.908356869 4 163514074 163514158 85 + 2.264 2.264 0.000
ENSG00000198498 E013 222.2101174 0.0002283853 0.1110394418 0.207068502 4 163515313 163515461 149 + 2.329 2.370 0.137
ENSG00000198498 E014 5.2651512 0.0199582360 0.0009954676 0.003942229 4 163515462 163516102 641 + 0.951 0.424 -2.258
ENSG00000198498 E015 2.3699760 0.0068151340 0.2535195126 0.390047599 4 163517072 163517433 362 + 0.446 0.634 0.886
ENSG00000198498 E016 170.7247461 0.0007374183 0.4684417543 0.607854168 4 163517434 163517476 43 + 2.241 2.223 -0.058
ENSG00000198498 E017 0.7427016 0.0153787590 0.0567734848 0.121071152 4 163517477 163517559 83 + 0.358 0.000 -10.834
ENSG00000198498 E018 415.4437674 0.0008972902 0.0005903967 0.002498614 4 163519334 163519981 648 + 2.644 2.580 -0.212
ENSG00000198498 E019 143.0772001 0.0135469839 0.0745663624 0.150843781 4 163519982 163520539 558 + 2.101 2.223 0.408