ENSG00000198492

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373812 ENSG00000198492 HEK293_OSMI2_2hA HEK293_TMG_2hB YTHDF2 protein_coding protein_coding 80.37833 68.37001 116.0281 3.602827 0.5379985 0.7629521 75.41751 67.1808 106.7124 3.384976 3.257305 0.6675275 0.9429292 0.9828667 0.9195333 -0.06333333 0.002185498 2.625667e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198492 E001 7.761851 0.0021328439 1.263943e-02 3.506116e-02 1 28736621 28736809 189 + 1.015 0.768 -0.941
ENSG00000198492 E002 25.682555 0.0041923418 4.656569e-02 1.030588e-01 1 28736940 28736949 10 + 1.455 1.371 -0.293
ENSG00000198492 E003 80.412811 0.0084893686 1.377432e-03 5.232823e-03 1 28736950 28736964 15 + 1.950 1.818 -0.444
ENSG00000198492 E004 246.921244 0.0103694768 3.712965e-03 1.233447e-02 1 28736965 28737046 82 + 2.420 2.325 -0.316
ENSG00000198492 E005 383.186467 0.0048685659 4.557097e-04 1.989328e-03 1 28737047 28737147 101 + 2.602 2.532 -0.231
ENSG00000198492 E006 36.700674 0.0005606534 3.508936e-12 7.875339e-11 1 28737148 28737657 510 + 1.681 1.292 -1.337
ENSG00000198492 E007 291.206580 0.0002756501 1.024127e-12 2.510582e-11 1 28737658 28737682 25 + 2.492 2.399 -0.310
ENSG00000198492 E008 2.773100 0.0054663013 4.955226e-01 6.323099e-01 1 28737750 28737797 48 + 0.499 0.657 0.715
ENSG00000198492 E009 1.329532 0.0892758195 8.379111e-01 8.986625e-01 1 28737798 28737829 32 + 0.342 0.437 0.536
ENSG00000198492 E010 445.629087 0.0004643856 3.745484e-13 9.822408e-12 1 28738259 28738329 71 + 2.669 2.592 -0.256
ENSG00000198492 E011 340.850133 0.0002031994 1.380473e-10 2.379460e-09 1 28738330 28738338 9 + 2.548 2.483 -0.214
ENSG00000198492 E012 1.394278 0.0109243274 7.334285e-01 8.246239e-01 1 28739091 28739200 110 + 0.342 0.442 0.562
ENSG00000198492 E013 4.331101 0.0426515306 9.635768e-01 9.810438e-01 1 28740303 28740398 96 + 0.705 0.765 0.247
ENSG00000198492 E014 3929.296482 0.0003143458 2.797768e-13 7.470455e-12 1 28742403 28743986 1584 + 3.576 3.599 0.075
ENSG00000198492 E015 2062.218831 0.0036160524 5.466800e-20 3.466094e-18 1 28768929 28769775 847 + 3.173 3.452 0.927