ENSG00000198467

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000329305 ENSG00000198467 HEK293_OSMI2_2hA HEK293_TMG_2hB TPM2 protein_coding protein_coding 8.431357 9.339595 5.092981 0.7306336 0.2449403 -0.8735636 2.8845563 4.7987065 1.5469178 0.64976986 0.15469043 -1.6269561 0.33770000 0.51310000 0.30293333 -0.210166667 0.03846829 0.02020183 FALSE TRUE
ENST00000471212 ENSG00000198467 HEK293_OSMI2_2hA HEK293_TMG_2hB TPM2 protein_coding retained_intron 8.431357 9.339595 5.092981 0.7306336 0.2449403 -0.8735636 0.4769343 0.2177683 0.5142652 0.04247332 0.17016170 1.2027296 0.06144583 0.02290000 0.10383333 0.080933333 0.02020183 0.02020183 TRUE TRUE
ENST00000486018 ENSG00000198467 HEK293_OSMI2_2hA HEK293_TMG_2hB TPM2 protein_coding retained_intron 8.431357 9.339595 5.092981 0.7306336 0.2449403 -0.8735636 0.7159471 0.6113716 0.5365355 0.17924493 0.06738689 -0.1851410 0.09210417 0.06343333 0.10680000 0.043366667 0.34687447 0.02020183 FALSE TRUE
ENST00000607559 ENSG00000198467 HEK293_OSMI2_2hA HEK293_TMG_2hB TPM2 protein_coding protein_coding 8.431357 9.339595 5.092981 0.7306336 0.2449403 -0.8735636 0.5233158 0.2655799 0.2406402 0.08132223 0.12970399 -0.1368524 0.06577917 0.02753333 0.04636667 0.018833333 0.93530838 0.02020183 FALSE TRUE
ENST00000644325 ENSG00000198467 HEK293_OSMI2_2hA HEK293_TMG_2hB TPM2 protein_coding protein_coding 8.431357 9.339595 5.092981 0.7306336 0.2449403 -0.8735636 0.5911570 0.5114951 0.4722466 0.12341523 0.05082747 -0.1128826 0.07769583 0.05740000 0.09280000 0.035400000 0.46730780 0.02020183 FALSE FALSE
ENST00000645482 ENSG00000198467 HEK293_OSMI2_2hA HEK293_TMG_2hB TPM2 protein_coding protein_coding 8.431357 9.339595 5.092981 0.7306336 0.2449403 -0.8735636 0.4410339 0.4764476 0.2382241 0.24389832 0.23822410 -0.9706412 0.05133750 0.05183333 0.04740000 -0.004433333 0.71413116 0.02020183 FALSE TRUE
MSTRG.32631.3 ENSG00000198467 HEK293_OSMI2_2hA HEK293_TMG_2hB TPM2 protein_coding   8.431357 9.339595 5.092981 0.7306336 0.2449403 -0.8735636 1.9765738 1.6969472 0.7349180 0.44820529 0.17544876 -1.1962649 0.21064167 0.18186667 0.14193333 -0.039933333 0.83133254 0.02020183 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198467 E001 0.0000000       9 35681992 35681992 1 -      
ENSG00000198467 E002 0.0000000       9 35681993 35682002 10 -      
ENSG00000198467 E003 0.0000000       9 35682003 35682007 5 -      
ENSG00000198467 E004 0.9211812 0.0137916067 0.117243400 0.21600757 9 35682008 35682013 6 - 0.001 0.313 9.469
ENSG00000198467 E005 26.6900779 0.0008013894 0.083753429 0.16542429 9 35682014 35682163 150 - 1.291 1.411 0.417
ENSG00000198467 E006 4.7362357 0.0135401411 0.399761827 0.54350154 9 35682164 35682268 105 - 0.813 0.681 -0.536
ENSG00000198467 E007 6.1441558 0.1321893040 0.377723496 0.52203420 9 35682269 35682523 255 - 0.930 0.768 -0.625
ENSG00000198467 E008 9.0898141 0.0484809764 0.007133655 0.02157142 9 35682524 35682904 381 - 1.218 0.809 -1.514
ENSG00000198467 E009 0.5159433 0.1539504073 0.241740900 0.37624022 9 35682905 35682931 27 - 0.301 0.084 -2.228
ENSG00000198467 E010 0.3686942 0.0276583937 0.543126515 0.67377164 9 35682932 35682936 5 - 0.176 0.083 -1.241
ENSG00000198467 E011 7.0188500 0.0025531840 0.280981073 0.42084849 9 35682937 35683241 305 - 0.955 0.813 -0.544
ENSG00000198467 E012 2.3271742 0.0087219086 0.237518141 0.37127851 9 35684041 35684245 205 - 0.603 0.395 -1.018
ENSG00000198467 E013 21.6916755 0.0031494822 0.206949153 0.33489277 9 35684246 35684250 5 - 1.218 1.316 0.344
ENSG00000198467 E014 38.0296115 0.0006524370 0.120614277 0.22083922 9 35684251 35684315 65 - 1.463 1.550 0.298
ENSG00000198467 E015 43.9266901 0.0007507031 0.269562868 0.40805661 9 35684488 35684550 63 - 1.557 1.610 0.181
ENSG00000198467 E016 2.8951941 0.2089145795 0.060684281 0.12778240 9 35684551 35684731 181 - 0.844 0.360 -2.211
ENSG00000198467 E017 32.3249715 0.0048971112 0.176699778 0.29695898 9 35684732 35684750 19 - 1.399 1.491 0.318
ENSG00000198467 E018 44.4091152 0.0015793898 0.027056583 0.06610850 9 35684751 35684807 57 - 1.506 1.630 0.423
ENSG00000198467 E019 11.2731103 0.0337877493 0.003709057 0.01232365 9 35684808 35685063 256 - 1.268 0.897 -1.348
ENSG00000198467 E020 22.1986191 0.0032582658 0.684614516 0.78756257 9 35685064 35685139 76 - 1.343 1.301 -0.146
ENSG00000198467 E021 1.6877435 0.0968752607 0.142673888 0.25166328 9 35685140 35685144 5 - 0.602 0.310 -1.524
ENSG00000198467 E022 4.6134908 0.0035294399 0.011179280 0.03159406 9 35685145 35685268 124 - 0.930 0.574 -1.450
ENSG00000198467 E023 53.3243765 0.0004666359 0.041294495 0.09342152 9 35685269 35685339 71 - 1.603 1.699 0.328
ENSG00000198467 E024 67.9471128 0.0004813192 0.991720191 0.99891590 9 35685434 35685551 118 - 1.786 1.775 -0.037
ENSG00000198467 E025 39.2458670 0.0056465273 0.669205168 0.77606075 9 35685647 35685684 38 - 1.532 1.549 0.056
ENSG00000198467 E026 47.3777493 0.0035450327 0.652678073 0.76334819 9 35685685 35685780 96 - 1.654 1.615 -0.132
ENSG00000198467 E027 0.1817044 0.0403928557 1.000000000   9 35686351 35686425 75 - 0.000 0.083 9.300
ENSG00000198467 E028 42.9390688 0.0007823304 0.405434004 0.54912461 9 35689146 35689271 126 - 1.624 1.565 -0.200
ENSG00000198467 E029 39.7576720 0.0249488081 0.309334945 0.45161934 9 35689704 35690056 353 - 1.619 1.518 -0.345