ENSG00000198431

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000503506 ENSG00000198431 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD1 protein_coding protein_coding 48.70737 25.12963 68.08878 3.935921 1.882863 1.437665 5.065018 1.5241219 8.571949 0.3223634 1.2624771 2.4838922 0.09596250 0.06210000 0.12596667 0.06386667 8.677785e-02 2.443718e-40 FALSE TRUE
ENST00000524698 ENSG00000198431 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD1 protein_coding protein_coding 48.70737 25.12963 68.08878 3.935921 1.882863 1.437665 17.210728 8.2147344 25.028265 1.5027471 0.3052767 1.6060936 0.35378333 0.32456667 0.36790000 0.04333333 2.128514e-01 2.443718e-40 FALSE TRUE
ENST00000525265 ENSG00000198431 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD1 protein_coding retained_intron 48.70737 25.12963 68.08878 3.935921 1.882863 1.437665 1.348519 4.5810772 0.000000 1.5932333 0.0000000 -8.8426889 0.05382917 0.17323333 0.00000000 -0.17323333 1.019057e-27 2.443718e-40   FALSE
ENST00000526580 ENSG00000198431 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD1 protein_coding protein_coding 48.70737 25.12963 68.08878 3.935921 1.882863 1.437665 3.694773 0.0000000 7.678441 0.0000000 0.5563559 9.5865472 0.05096250 0.00000000 0.11253333 0.11253333 2.443718e-40 2.443718e-40 FALSE FALSE
ENST00000526691 ENSG00000198431 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD1 protein_coding protein_coding 48.70737 25.12963 68.08878 3.935921 1.882863 1.437665 3.235439 0.9176418 4.677823 0.1221689 0.4052741 2.3372784 0.06539583 0.03676667 0.06853333 0.03176667 3.511931e-03 2.443718e-40 FALSE TRUE
ENST00000529546 ENSG00000198431 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD1 protein_coding protein_coding 48.70737 25.12963 68.08878 3.935921 1.882863 1.437665 2.800508 2.4590942 3.394550 0.2452409 0.3066249 0.4634820 0.06796250 0.10060000 0.05013333 -0.05046667 1.183537e-02 2.443718e-40 FALSE TRUE
MSTRG.7893.9 ENSG00000198431 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD1 protein_coding   48.70737 25.12963 68.08878 3.935921 1.882863 1.437665 8.476124 5.0085860 9.634644 0.5035491 0.6687610 0.9424471 0.18330833 0.20250000 0.14206667 -0.06043333 8.522998e-02 2.443718e-40 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198431 E001 0.0000000       12 104215779 104215893 115 +      
ENSG00000198431 E002 0.0000000       12 104224816 104224901 86 +      
ENSG00000198431 E003 0.0000000       12 104251527 104251545 19 +      
ENSG00000198431 E004 0.0000000       12 104251546 104251678 133 +      
ENSG00000198431 E005 0.1515154 0.0431618817 1.000000e+00   12 104258019 104258079 61 + 0.079 0.000 -8.113
ENSG00000198431 E006 0.0000000       12 104258080 104258268 189 +      
ENSG00000198431 E007 0.0000000       12 104276605 104276686 82 +      
ENSG00000198431 E008 0.0000000       12 104282882 104282976 95 +      
ENSG00000198431 E009 0.0000000       12 104284276 104284406 131 +      
ENSG00000198431 E010 0.0000000       12 104286002 104286160 159 +      
ENSG00000198431 E011 0.0000000       12 104286682 104286880 199 +      
ENSG00000198431 E012 0.1451727 0.0435468582 1.000000e+00   12 104286881 104286924 44 + 0.079 0.000 -9.724
ENSG00000198431 E013 1.6502694 0.0316205575 1.211436e-01 2.215703e-01 12 104286925 104286958 34 + 0.476 0.185 -1.910
ENSG00000198431 E014 2.4190073 0.1664086248 2.609637e-01 3.985617e-01 12 104286959 104286977 19 + 0.578 0.315 -1.387
ENSG00000198431 E015 4.3346300 0.0642210591 4.750380e-02 1.047435e-01 12 104286978 104286989 12 + 0.791 0.413 -1.705
ENSG00000198431 E016 4.7785671 0.0484634236 2.152151e-02 5.468623e-02 12 104286990 104286994 5 + 0.831 0.413 -1.863
ENSG00000198431 E017 16.1979086 0.0174565561 5.399162e-02 1.162533e-01 12 104286995 104287021 27 + 1.259 1.064 -0.694
ENSG00000198431 E018 16.9092753 0.0068584067 1.376283e-02 3.768282e-02 12 104287022 104287023 2 + 1.282 1.064 -0.777
ENSG00000198431 E019 18.5260304 0.0071205630 3.647255e-02 8.447978e-02 12 104287024 104287031 8 + 1.309 1.137 -0.605
ENSG00000198431 E020 41.3000845 0.0004982087 7.473579e-03 2.244597e-02 12 104287032 104287047 16 + 1.633 1.509 -0.422
ENSG00000198431 E021 43.0547391 0.0004984239 8.206351e-03 2.430689e-02 12 104287048 104287048 1 + 1.649 1.530 -0.404
ENSG00000198431 E022 53.1954340 0.0004326572 6.477165e-02 1.346693e-01 12 104287049 104287056 8 + 1.722 1.664 -0.198
ENSG00000198431 E023 104.7876251 0.0023586125 1.121665e-02 3.168603e-02 12 104287057 104287109 53 + 2.017 1.938 -0.264
ENSG00000198431 E024 40.2467446 0.0004973057 1.711112e-01 2.896192e-01 12 104287110 104287321 212 + 1.599 1.556 -0.146
ENSG00000198431 E025 20.8267769 0.0009661555 3.982463e-01 5.419834e-01 12 104287322 104287346 25 + 1.321 1.291 -0.105
ENSG00000198431 E026 0.0000000       12 104287347 104287350 4 +      
ENSG00000198431 E027 0.0000000       12 104287351 104287367 17 +      
ENSG00000198431 E028 0.4460135 0.0312524023 3.464725e-01 4.905987e-01 12 104287368 104287431 64 + 0.204 0.000 -11.459
ENSG00000198431 E029 3.5870958 0.0081899846 7.349718e-02 1.491188e-01 12 104288718 104288894 177 + 0.698 0.414 -1.325
ENSG00000198431 E030 6.4689442 0.0025096914 4.336045e-05 2.479552e-04 12 104288895 104288930 36 + 0.963 0.314 -2.947
ENSG00000198431 E031 181.0106731 0.0082658755 8.477855e-04 3.429794e-03 12 104288931 104289040 110 + 2.271 2.119 -0.508
ENSG00000198431 E032 1.1028881 0.0118906063 4.500904e-01 5.912580e-01 12 104289041 104289403 363 + 0.255 0.413 0.994
ENSG00000198431 E033 1.1113958 0.0122903267 3.633900e-01 5.078003e-01 12 104289466 104289542 77 + 0.342 0.185 -1.174
ENSG00000198431 E034 8.6967884 0.0617944216 7.729235e-01 8.534545e-01 12 104290993 104291104 112 + 0.935 1.001 0.248
ENSG00000198431 E035 2.0680685 0.0067316881 1.904736e-01 3.143531e-01 12 104309759 104309850 92 + 0.531 0.314 -1.176
ENSG00000198431 E036 2.7635381 0.0065929476 7.167184e-01 8.122862e-01 12 104309851 104309950 100 + 0.531 0.621 0.409
ENSG00000198431 E037 1.8810641 0.0096544774 7.486893e-01 8.358444e-01 12 104309951 104310099 149 + 0.447 0.414 -0.175
ENSG00000198431 E038 281.2810538 0.0049303742 8.235767e-05 4.391582e-04 12 104311290 104311412 123 + 2.457 2.324 -0.443
ENSG00000198431 E039 250.6314196 0.0008398286 2.586553e-07 2.425095e-06 12 104313245 104313317 73 + 2.402 2.293 -0.362
ENSG00000198431 E040 320.7065197 0.0003074979 5.834243e-12 1.260584e-10 12 104315777 104315896 120 + 2.511 2.391 -0.402
ENSG00000198431 E041 0.1515154 0.0431618817 1.000000e+00   12 104315897 104315901 5 + 0.079 0.000 -9.729
ENSG00000198431 E042 353.4275992 0.0003372513 5.451717e-08 5.827520e-07 12 104318913 104319055 143 + 2.543 2.462 -0.271
ENSG00000198431 E043 300.6633686 0.0003600628 1.793770e-07 1.735374e-06 12 104319470 104319585 116 + 2.475 2.389 -0.287
ENSG00000198431 E044 419.3636082 0.0001808376 1.093500e-03 4.281941e-03 12 104321091 104321316 226 + 2.601 2.578 -0.077
ENSG00000198431 E045 324.3269401 0.0001458700 2.784895e-03 9.629489e-03 12 104325337 104325429 93 + 2.491 2.468 -0.079
ENSG00000198431 E046 312.3997163 0.0007564726 1.702344e-02 4.498653e-02 12 104326347 104326423 77 + 2.475 2.455 -0.064
ENSG00000198431 E047 398.3766021 0.0012223934 1.881162e-01 3.113605e-01 12 104327515 104327671 157 + 2.571 2.579 0.026
ENSG00000198431 E048 285.5842153 0.0001874045 1.464064e-01 2.567934e-01 12 104331534 104331641 108 + 2.427 2.435 0.025
ENSG00000198431 E049 0.4407149 0.0217681645 8.867306e-01 9.315561e-01 12 104334127 104334236 110 + 0.146 0.185 0.408
ENSG00000198431 E050 265.3512528 0.0001992055 6.789636e-01 7.832831e-01 12 104334237 104334332 96 + 2.388 2.419 0.103
ENSG00000198431 E051 329.8090604 0.0009075881 4.261012e-01 5.689594e-01 12 104339139 104339273 135 + 2.472 2.530 0.194
ENSG00000198431 E052 4.2834973 0.0038593284 6.167365e-01 7.347340e-01 12 104346019 104346155 137 + 0.715 0.673 -0.176
ENSG00000198431 E053 1997.1000496 0.0008738235 8.920104e-47 4.579639e-44 12 104348353 104350307 1955 + 3.194 3.402 0.691