ENSG00000198420

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000479870 ENSG00000198420 HEK293_OSMI2_2hA HEK293_TMG_2hB TCAF1 protein_coding protein_coding 27.73454 16.96285 36.3396 1.469099 0.7776308 1.09871 20.773157 14.813408 24.466155 0.8448400 1.2434181 0.7234998 0.7743375 0.87830000 0.6725 -0.2058000 0.003705620 0.00370562 FALSE TRUE
MSTRG.30865.2 ENSG00000198420 HEK293_OSMI2_2hA HEK293_TMG_2hB TCAF1 protein_coding   27.73454 16.96285 36.3396 1.469099 0.7776308 1.09871 4.166664 1.355117 7.430092 0.3674002 0.7596868 2.4462960 0.1339042 0.07766667 0.2055 0.1278333 0.005849126 0.00370562 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198420 E001 94.2682847 0.0247284447 2.276689e-10 3.774498e-09 7 143851375 143851648 274 - 1.652 2.257 2.033
ENSG00000198420 E002 619.8741471 0.0077075711 7.592362e-11 1.365436e-09 7 143851649 143853695 2047 - 2.641 2.944 1.008
ENSG00000198420 E003 3.5388051 0.0426100598 9.749939e-01 9.884235e-01 7 143853696 143853827 132 - 0.593 0.664 0.310
ENSG00000198420 E004 98.3129221 0.0052900319 3.863990e-03 1.276010e-02 7 143853828 143854142 315 - 1.989 1.922 -0.228
ENSG00000198420 E005 13.7248407 0.0012901529 8.939250e-05 4.721255e-04 7 143857074 143857099 26 - 1.226 0.882 -1.259
ENSG00000198420 E006 166.2076612 0.0006802073 4.911435e-06 3.501906e-05 7 143857100 143857350 251 - 2.213 2.153 -0.204
ENSG00000198420 E007 78.6542228 0.0006744634 1.587087e-03 5.916931e-03 7 143858824 143859161 338 - 1.891 1.834 -0.195
ENSG00000198420 E008 0.9223296 0.0136968632 3.725400e-01 5.169840e-01 7 143860208 143860447 240 - 0.310 0.179 -1.034
ENSG00000198420 E009 0.6558305 0.0507570381 5.001714e-01 6.364373e-01 7 143861095 143861308 214 - 0.151 0.305 1.290
ENSG00000198420 E010 0.3634088 0.3258394826 1.180241e-01   7 143862416 143862513 98 - 0.000 0.306 12.539
ENSG00000198420 E011 100.0945840 0.0119736476 6.485216e-03 1.988488e-02 7 143862802 143863796 995 - 2.005 1.915 -0.303
ENSG00000198420 E012 151.4766513 0.0082011960 1.685624e-05 1.063108e-04 7 143875989 143876107 119 - 2.197 2.057 -0.471
ENSG00000198420 E013 129.3827323 0.0015964862 1.105493e-10 1.936319e-09 7 143876108 143876158 51 - 2.138 1.969 -0.567
ENSG00000198420 E014 84.6870526 0.0004532750 9.710993e-14 2.766910e-12 7 143876159 143876171 13 - 1.975 1.727 -0.837
ENSG00000198420 E015 268.5327238 0.0011341446 1.813784e-06 1.424551e-05 7 143876172 143876383 212 - 2.418 2.373 -0.151
ENSG00000198420 E016 253.6136448 0.0001892801 2.281972e-01 3.602816e-01 7 143876384 143876622 239 - 2.360 2.413 0.177
ENSG00000198420 E017 1.0759214 0.0120173389 2.627683e-01 4.005687e-01 7 143881923 143882099 177 - 0.352 0.179 -1.297
ENSG00000198420 E018 0.1472490 0.0431422905 1.000000e+00   7 143882736 143882905 170 - 0.082 0.000 -9.230
ENSG00000198420 E019 0.3729606 0.0301570491 6.050515e-01 7.254759e-01 7 143885210 143885370 161 - 0.082 0.179 1.290
ENSG00000198420 E020 65.0859389 0.0007472312 4.563217e-02 1.013574e-01 7 143901961 143902026 66 - 1.797 1.782 -0.050
ENSG00000198420 E021 82.2753854 0.0009900704 5.327021e-01 6.650202e-01 7 143902027 143902073 47 - 1.854 1.960 0.356
ENSG00000198420 E022 75.0325625 0.0049694522 4.699100e-01 6.091320e-01 7 143902074 143902198 125 - 1.811 1.928 0.395