ENSG00000198399

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361999 ENSG00000198399 HEK293_OSMI2_2hA HEK293_TMG_2hB ITSN2 protein_coding protein_coding 6.075079 1.721275 7.679017 0.2136395 0.2700474 2.150964 1.81450283 0.8468461 1.9960866 0.08175712 0.27327877 1.22727585 0.34277083 0.51216667 0.25903333 -0.25313333 6.571794e-02 1.448996e-09 FALSE TRUE
ENST00000416160 ENSG00000198399 HEK293_OSMI2_2hA HEK293_TMG_2hB ITSN2 protein_coding protein_coding 6.075079 1.721275 7.679017 0.2136395 0.2700474 2.150964 1.14875563 0.3457533 0.9039884 0.02255833 0.47400550 1.36129887 0.18194167 0.20510000 0.11370000 -0.09140000 6.594655e-01 1.448996e-09 FALSE FALSE
ENST00000427234 ENSG00000198399 HEK293_OSMI2_2hA HEK293_TMG_2hB ITSN2 protein_coding nonsense_mediated_decay 6.075079 1.721275 7.679017 0.2136395 0.2700474 2.150964 0.08711227 0.2326235 0.0000000 0.17051915 0.00000000 -4.60064711 0.03181250 0.11560000 0.00000000 -0.11560000 4.787380e-02 1.448996e-09 FALSE TRUE
ENST00000478720 ENSG00000198399 HEK293_OSMI2_2hA HEK293_TMG_2hB ITSN2 protein_coding retained_intron 6.075079 1.721275 7.679017 0.2136395 0.2700474 2.150964 0.20674753 0.1850483 0.1778433 0.03077014 0.03848659 -0.05430226 0.06455833 0.11350000 0.02353333 -0.08996667 6.921504e-03 1.448996e-09   FALSE
MSTRG.18048.13 ENSG00000198399 HEK293_OSMI2_2hA HEK293_TMG_2hB ITSN2 protein_coding   6.075079 1.721275 7.679017 0.2136395 0.2700474 2.150964 0.50836794 0.0000000 1.6738437 0.00000000 0.45968693 7.39561445 0.06688333 0.00000000 0.22273333 0.22273333 1.260622e-04 1.448996e-09 FALSE TRUE
MSTRG.18048.18 ENSG00000198399 HEK293_OSMI2_2hA HEK293_TMG_2hB ITSN2 protein_coding   6.075079 1.721275 7.679017 0.2136395 0.2700474 2.150964 1.44648358 0.0000000 2.0254110 0.00000000 0.31641792 7.66917631 0.14982500 0.00000000 0.26190000 0.26190000 1.448996e-09 1.448996e-09 FALSE TRUE
MSTRG.18048.5 ENSG00000198399 HEK293_OSMI2_2hA HEK293_TMG_2hB ITSN2 protein_coding   6.075079 1.721275 7.679017 0.2136395 0.2700474 2.150964 0.09488458 0.0000000 0.3871190 0.00000000 0.38711905 5.31149966 0.01100833 0.00000000 0.05373333 0.05373333 1.000000e+00 1.448996e-09 FALSE TRUE
MSTRG.18048.7 ENSG00000198399 HEK293_OSMI2_2hA HEK293_TMG_2hB ITSN2 protein_coding   6.075079 1.721275 7.679017 0.2136395 0.2700474 2.150964 0.27016243 0.1055730 0.0000000 0.10557296 0.00000000 -3.53073205 0.07586667 0.04976667 0.00000000 -0.04976667 4.531895e-01 1.448996e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198399 E001 8.4913032 0.0328417317 1.261305e-07 1.256821e-06 2 24202864 24203058 195 - 0.635 1.352 2.693
ENSG00000198399 E002 21.3170052 0.0277582976 1.145955e-09 1.680063e-08 2 24203059 24203281 223 - 1.027 1.692 2.319
ENSG00000198399 E003 19.0913830 0.0568178709 3.546661e-05 2.070519e-04 2 24203282 24203413 132 - 1.020 1.601 2.036
ENSG00000198399 E004 15.7942604 0.0482954886 7.102508e-05 3.851358e-04 2 24203414 24203541 128 - 0.961 1.502 1.920
ENSG00000198399 E005 10.5347458 0.0028244796 5.511093e-05 3.072301e-04 2 24203542 24203592 51 - 0.847 1.285 1.598
ENSG00000198399 E006 21.4948563 0.0009389232 3.133399e-07 2.887504e-06 2 24203593 24203783 191 - 1.140 1.549 1.426
ENSG00000198399 E007 2.8315038 0.0056046100 6.289954e-03 1.937362e-02 2 24203784 24204244 461 - 0.372 0.821 2.052
ENSG00000198399 E008 19.0088659 0.0010029682 6.370624e-06 4.429300e-05 2 24204245 24204362 118 - 1.101 1.484 1.346
ENSG00000198399 E009 14.2708238 0.0012672231 6.901357e-06 4.760044e-05 2 24204363 24204418 56 - 0.968 1.396 1.527
ENSG00000198399 E010 9.9864002 0.0084151273 2.166847e-03 7.740951e-03 2 24205214 24205265 52 - 0.856 1.216 1.323
ENSG00000198399 E011 8.5597581 0.0047833846 4.659555e-02 1.031116e-01 2 24205266 24205297 32 - 0.838 1.088 0.934
ENSG00000198399 E012 1.7274724 0.0081851966 4.433585e-01 5.849334e-01 2 24205298 24205693 396 - 0.344 0.492 0.806
ENSG00000198399 E013 0.1515154 0.0432648540 1.000000e+00   2 24206244 24206275 32 - 0.061 0.000 -8.856
ENSG00000198399 E014 13.2601345 0.0089144546 8.234035e-03 2.437745e-02 2 24208237 24208319 83 - 0.995 1.284 1.035
ENSG00000198399 E015 19.1799521 0.0010152760 1.769723e-04 8.652544e-04 2 24209100 24209221 122 - 1.131 1.453 1.131
ENSG00000198399 E016 22.9351104 0.0008357931 6.840510e-05 3.724533e-04 2 24209818 24210033 216 - 1.206 1.523 1.100
ENSG00000198399 E017 0.1472490 0.0428695429 1.000000e+00   2 24210034 24210329 296 - 0.061 0.000 -8.857
ENSG00000198399 E018 15.4179537 0.0056882447 4.930047e-02 1.079250e-01 2 24210780 24210947 168 - 1.079 1.285 0.730
ENSG00000198399 E019 7.4458920 0.0436282636 9.153608e-02 1.775311e-01 2 24212650 24212748 99 - 0.776 1.036 0.991
ENSG00000198399 E020 15.9291740 0.0012671146 4.533071e-04 1.979797e-03 2 24216049 24216232 184 - 1.057 1.383 1.156
ENSG00000198399 E021 13.4362006 0.0021371288 3.336494e-03 1.125314e-02 2 24217907 24218013 107 - 1.002 1.300 1.067
ENSG00000198399 E022 0.0000000       2 24220319 24220944 626 -      
ENSG00000198399 E023 18.0596252 0.0010663125 4.927468e-02 1.078772e-01 2 24220945 24221066 122 - 1.145 1.330 0.653
ENSG00000198399 E024 110.8666668 0.0018502658 1.975209e-02 5.096391e-02 2 24238933 24241963 3031 - 1.977 1.874 -0.345
ENSG00000198399 E025 3.7538004 0.0147010803 3.979429e-02 9.064457e-02 2 24241964 24241964 1 - 0.664 0.231 -2.362
ENSG00000198399 E026 4.3513293 0.0087726886 1.853624e-02 4.831175e-02 2 24241965 24242007 43 - 0.718 0.231 -2.586
ENSG00000198399 E027 2.7292862 0.0053462420 1.242856e-01 2.261081e-01 2 24242008 24242065 58 - 0.552 0.231 -1.866
ENSG00000198399 E028 11.1319910 0.0489391646 4.598315e-06 3.301512e-05 2 24242066 24242206 141 - 1.091 0.000 -14.031
ENSG00000198399 E029 39.9196208 0.0021641603 3.786002e-02 8.708677e-02 2 24246129 24246320 192 - 1.549 1.396 -0.525
ENSG00000198399 E030 22.3174994 0.0008636469 1.229251e-01 2.241237e-01 2 24246797 24246893 97 - 1.301 1.157 -0.508
ENSG00000198399 E031 18.7593579 0.0013825913 6.762855e-01 7.813021e-01 2 24248629 24248750 122 - 1.214 1.178 -0.130
ENSG00000198399 E032 19.5583139 0.0009985874 4.817523e-01 6.199456e-01 2 24248837 24248882 46 - 1.241 1.177 -0.226
ENSG00000198399 E033 37.2938765 0.0007186936 7.952821e-01 8.692560e-01 2 24252345 24252511 167 - 1.498 1.484 -0.046
ENSG00000198399 E034 25.7251634 0.0007751418 5.466532e-01 6.767894e-01 2 24254367 24254431 65 - 1.329 1.383 0.188
ENSG00000198399 E035 39.5880145 0.0005588783 8.244474e-01 8.894103e-01 2 24257888 24258093 206 - 1.512 1.532 0.068
ENSG00000198399 E036 34.0962107 0.0006200036 8.045057e-01 8.756415e-01 2 24261106 24261250 145 - 1.456 1.443 -0.047
ENSG00000198399 E037 31.7959938 0.0006498872 8.220975e-02 1.629887e-01 2 24261561 24261742 182 - 1.452 1.315 -0.472
ENSG00000198399 E038 20.7675201 0.0189344469 5.996066e-03 1.859996e-02 2 24270671 24270768 98 - 1.300 0.943 -1.287
ENSG00000198399 E039 11.1197008 0.0056498509 5.586061e-02 1.194495e-01 2 24271766 24271804 39 - 1.039 0.773 -1.014
ENSG00000198399 E040 32.6384553 0.0252507955 3.579803e-03 1.195436e-02 2 24271805 24271941 137 - 1.486 1.140 -1.210
ENSG00000198399 E041 30.0866441 0.0216287401 5.322558e-02 1.148938e-01 2 24275713 24275849 137 - 1.439 1.219 -0.769
ENSG00000198399 E042 0.0000000       2 24284763 24284843 81 -      
ENSG00000198399 E043 23.7557613 0.0130215631 3.160851e-01 4.588470e-01 2 24286212 24286322 111 - 1.323 1.218 -0.369
ENSG00000198399 E044 15.2533566 0.0024114321 9.279509e-01 9.586428e-01 2 24286323 24286351 29 - 1.121 1.135 0.051
ENSG00000198399 E045 0.0000000       2 24293261 24293687 427 -      
ENSG00000198399 E046 20.2401199 0.0057044342 3.215579e-01 4.648220e-01 2 24293688 24293775 88 - 1.256 1.157 -0.350
ENSG00000198399 E047 31.3619733 0.0183111989 3.447285e-01 4.888270e-01 2 24295664 24295804 141 - 1.437 1.346 -0.317
ENSG00000198399 E048 0.0000000       2 24296852 24296917 66 -      
ENSG00000198399 E049 31.1389959 0.0099155641 2.485262e-02 6.156768e-02 2 24298665 24298814 150 - 1.452 1.236 -0.749
ENSG00000198399 E050 44.1122986 0.0006128826 5.895413e-06 4.129972e-05 2 24299909 24300171 263 - 1.615 1.269 -1.196
ENSG00000198399 E051 20.3342348 0.0008963547 3.854633e-07 3.485674e-06 2 24301154 24301239 86 - 1.317 0.654 -2.491
ENSG00000198399 E052 27.6438048 0.0154206339 7.105504e-04 2.936618e-03 2 24301965 24302102 138 - 1.425 1.036 -1.377
ENSG00000198399 E053 18.4970557 0.0489070834 4.192992e-02 9.459989e-02 2 24303799 24303862 64 - 1.248 0.946 -1.093
ENSG00000198399 E054 24.9544698 0.0029074434 9.873252e-03 2.845409e-02 2 24308617 24308756 140 - 1.365 1.113 -0.890
ENSG00000198399 E055 0.1451727 0.0426869491 1.000000e+00   2 24308878 24308952 75 - 0.061 0.000 -8.858
ENSG00000198399 E056 16.8311305 0.0033205330 2.231989e-02 5.633935e-02 2 24310284 24310343 60 - 1.206 0.941 -0.963
ENSG00000198399 E057 14.4704393 0.0078061940 5.492532e-02 1.178699e-01 2 24310344 24310380 37 - 1.145 0.904 -0.884
ENSG00000198399 E058 28.9656944 0.0085895463 3.231596e-03 1.094886e-02 2 24310489 24310692 204 - 1.435 1.136 -1.049
ENSG00000198399 E059 0.0000000       2 24311620 24311662 43 -      
ENSG00000198399 E060 19.4778251 0.0067769023 4.260528e-02 9.582509e-02 2 24312212 24312375 164 - 1.260 1.036 -0.802
ENSG00000198399 E061 11.7359693 0.0149785630 8.428350e-02 1.662736e-01 2 24313460 24313523 64 - 1.063 0.821 -0.909
ENSG00000198399 E062 14.6680539 0.0208313868 6.770165e-03 2.062601e-02 2 24315132 24315224 93 - 1.168 0.772 -1.482
ENSG00000198399 E063 1.0457324 0.0319831286 2.081199e-01 3.362148e-01 2 24321814 24321880 67 - 0.313 0.000 -11.502
ENSG00000198399 E064 0.0000000       2 24326660 24326681 22 -      
ENSG00000198399 E065 12.4658586 0.0172517456 5.926941e-02 1.253864e-01 2 24328052 24328115 64 - 1.090 0.821 -1.009
ENSG00000198399 E066 0.5911862 0.0184560147 4.924268e-01 6.296107e-01 2 24359839 24359876 38 - 0.205 0.000 -10.831
ENSG00000198399 E067 12.7944759 0.0054691544 5.007907e-03 1.595153e-02 2 24360304 24360576 273 - 1.111 0.717 -1.498