ENSG00000198393

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328654 ENSG00000198393 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF26 protein_coding protein_coding 2.870374 1.04707 4.409029 0.09169578 0.08533908 2.063659 0.1227330 0.07833095 0.1460764 0.01253620 0.01992286 0.82126138 0.05625000 0.07803333 0.03323333 -0.04480000 0.3438884265 0.0009326155 FALSE TRUE
ENST00000534834 ENSG00000198393 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF26 protein_coding retained_intron 2.870374 1.04707 4.409029 0.09169578 0.08533908 2.063659 0.1823838 0.07122121 0.1044467 0.02517682 0.02087801 0.49474743 0.08667500 0.06623333 0.02386667 -0.04236667 0.3928622905 0.0009326155 FALSE TRUE
ENST00000537956 ENSG00000198393 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF26 protein_coding processed_transcript 2.870374 1.04707 4.409029 0.09169578 0.08533908 2.063659 0.2955138 0.05024537 0.7079423 0.05024537 0.18146516 3.57494565 0.08067917 0.04760000 0.16010000 0.11250000 0.3008416281 0.0009326155   FALSE
ENST00000540238 ENSG00000198393 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF26 protein_coding protein_coding 2.870374 1.04707 4.409029 0.09169578 0.08533908 2.063659 0.6755456 0.00000000 0.7875347 0.00000000 0.21363861 6.31747531 0.18742083 0.00000000 0.17730000 0.17730000 0.0009326155 0.0009326155 FALSE TRUE
ENST00000544181 ENSG00000198393 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF26 protein_coding protein_coding 2.870374 1.04707 4.409029 0.09169578 0.08533908 2.063659 0.4818941 0.05131742 1.0336348 0.05131742 0.18822962 4.08917617 0.15329583 0.05803333 0.23613333 0.17810000 0.2087431913 0.0009326155 FALSE TRUE
MSTRG.8363.4 ENSG00000198393 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF26 protein_coding   2.870374 1.04707 4.409029 0.09169578 0.08533908 2.063659 0.3970225 0.22174981 0.9596190 0.11171260 0.18867274 2.06484986 0.12483333 0.19823333 0.21646667 0.01823333 0.8984480212 0.0009326155 TRUE TRUE
MSTRG.8363.8 ENSG00000198393 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF26 protein_coding   2.870374 1.04707 4.409029 0.09169578 0.08533908 2.063659 0.5494955 0.36817384 0.5376058 0.18442977 0.26896077 0.53408827 0.22206250 0.36333333 0.12356667 -0.23976667 0.7568306418 0.0009326155 TRUE TRUE
MSTRG.8363.9 ENSG00000198393 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF26 protein_coding   2.870374 1.04707 4.409029 0.09169578 0.08533908 2.063659 0.1436563 0.10223135 0.1013142 0.10223135 0.10131421 -0.01183793 0.07487500 0.09686667 0.02243333 -0.07443333 0.8286880909 0.0009326155 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198393 E001 0.000000       12 132986365 132986366 2 +      
ENSG00000198393 E002 1.743494 0.0180036855 0.529555271 0.662326912 12 132986367 132986417 51 + 0.442 0.318 -0.711
ENSG00000198393 E003 5.041200 0.0414023765 0.912973327 0.948883210 12 132986418 132986427 10 + 0.757 0.726 -0.126
ENSG00000198393 E004 9.628748 0.0018272658 0.188651519 0.312039677 12 132986428 132986442 15 + 1.034 0.873 -0.601
ENSG00000198393 E005 12.743705 0.0025960496 0.143463220 0.252721460 12 132986443 132986467 25 + 1.145 0.984 -0.587
ENSG00000198393 E006 15.021027 0.0193154200 0.084642467 0.166821971 12 132986468 132986532 65 + 1.224 1.008 -0.776
ENSG00000198393 E007 12.916315 0.0145336643 0.031578097 0.075026545 12 132986533 132986592 60 + 1.175 0.904 -0.993
ENSG00000198393 E008 6.599631 0.0028619067 0.017031129 0.045004341 12 132986593 132986607 15 + 0.928 0.568 -1.468
ENSG00000198393 E009 16.679839 0.0179622075 0.091878707 0.178042485 12 132986608 132986873 266 + 1.267 1.070 -0.701
ENSG00000198393 E010 8.401212 0.0020148526 0.146377759 0.256750278 12 132987665 132987768 104 + 0.993 0.806 -0.713
ENSG00000198393 E011 0.481513 0.0207287535 0.149165121 0.260524986 12 133001633 133001731 99 + 0.078 0.318 2.456
ENSG00000198393 E012 2.030501 0.0074987701 0.086480271 0.169774695 12 133004404 133006056 1653 + 0.338 0.627 1.459
ENSG00000198393 E013 10.727696 0.0220854556 0.667592747 0.774774674 12 133006057 133007041 985 + 1.050 0.986 -0.236
ENSG00000198393 E014 17.202976 0.0012737034 0.253874497 0.390504955 12 133007042 133007168 127 + 1.253 1.145 -0.383
ENSG00000198393 E015 14.431120 0.0324878567 0.110628460 0.206454512 12 133007437 133007532 96 + 1.202 0.990 -0.765
ENSG00000198393 E016 110.472577 0.0073456859 0.200639853 0.326995562 12 133010136 133011500 1365 + 2.028 1.971 -0.191
ENSG00000198393 E017 32.793397 0.0007464824 0.004903635 0.015661788 12 133011501 133011852 352 + 1.439 1.606 0.570
ENSG00000198393 E018 12.171156 0.0164580684 0.055795504 0.119338529 12 133011853 133012204 352 + 1.010 1.221 0.762
ENSG00000198393 E019 13.075450 0.0149399975 0.001701271 0.006287212 12 133012205 133012324 120 + 0.993 1.319 1.170
ENSG00000198393 E020 28.175431 0.0099451300 0.166404895 0.283520322 12 133012325 133025301 12977 + 1.401 1.506 0.364
ENSG00000198393 E021 17.236830 0.0073537380 0.001728433 0.006372413 12 133025302 133026551 1250 + 1.120 1.394 0.964
ENSG00000198393 E022 2.809517 0.1699242150 0.027208175 0.066413790 12 133026552 133026718 167 + 0.338 0.837 2.316
ENSG00000198393 E023 2.142188 0.0315325057 0.082850769 0.164012473 12 133026719 133027102 384 + 0.376 0.676 1.446
ENSG00000198393 E024 0.000000       12 133032631 133032952 322 +