ENSG00000198382

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356136 ENSG00000198382 HEK293_OSMI2_2hA HEK293_TMG_2hB UVRAG protein_coding protein_coding 5.729766 3.174596 7.625791 0.3304052 0.5098225 1.261667 2.9852915 1.17387212 4.036248 0.11627243 0.03535907 1.773071 0.53594167 0.37713333 0.5341667 0.1570333 1.949433e-01 2.094983e-20 FALSE TRUE
ENST00000528420 ENSG00000198382 HEK293_OSMI2_2hA HEK293_TMG_2hB UVRAG protein_coding protein_coding 5.729766 3.174596 7.625791 0.3304052 0.5098225 1.261667 0.5150270 1.15321517 0.000000 0.04596139 0.00000000 -6.861974 0.13353333 0.37336667 0.0000000 -0.3733667 2.094983e-20 2.094983e-20 FALSE TRUE
ENST00000532130 ENSG00000198382 HEK293_OSMI2_2hA HEK293_TMG_2hB UVRAG protein_coding protein_coding 5.729766 3.174596 7.625791 0.3304052 0.5098225 1.261667 0.1675005 0.63907214 0.000000 0.33541998 0.00000000 -6.020307 0.04689583 0.18760000 0.0000000 -0.1876000 6.622244e-02 2.094983e-20 FALSE TRUE
MSTRG.6009.3 ENSG00000198382 HEK293_OSMI2_2hA HEK293_TMG_2hB UVRAG protein_coding   5.729766 3.174596 7.625791 0.3304052 0.5098225 1.261667 1.7841146 0.09543561 3.261556 0.09543561 0.36514500 4.955543 0.22588750 0.02493333 0.4251333 0.4002000 5.478050e-03 2.094983e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198382 E001 17.1991737 0.0103444947 5.892688e-03 1.832856e-02 11 75815210 75815524 315 + 1.332 1.094 -0.841
ENSG00000198382 E002 0.0000000       11 75838944 75839042 99 +      
ENSG00000198382 E003 20.0561688 0.0010079904 2.967483e-05 1.768087e-04 11 75851883 75852000 118 + 1.416 1.109 -1.080
ENSG00000198382 E004 0.2934659 0.0283481225 7.130348e-01   11 75859611 75859666 56 + 0.094 0.158 0.864
ENSG00000198382 E005 16.1652334 0.0014684655 3.888566e-02 8.896959e-02 11 75861746 75861780 35 + 1.280 1.138 -0.505
ENSG00000198382 E006 0.0000000       11 75878404 75878485 82 +      
ENSG00000198382 E007 41.8285993 0.0005237119 1.122299e-03 4.378063e-03 11 75879879 75880040 162 + 1.677 1.536 -0.479
ENSG00000198382 E008 30.3201992 0.0006959814 2.075809e-02 5.307739e-02 11 75888829 75888903 75 + 1.532 1.423 -0.374
ENSG00000198382 E009 21.1507857 0.0144080499 2.946530e-02 7.090301e-02 11 75911954 75911978 25 + 1.400 1.226 -0.608
ENSG00000198382 E010 27.4280761 0.0008139802 1.397036e-02 3.815641e-02 11 75911979 75912039 61 + 1.497 1.369 -0.439
ENSG00000198382 E011 0.6172225 0.4109756699 8.154874e-01 8.831778e-01 11 75916133 75916784 652 + 0.235 0.159 -0.704
ENSG00000198382 E012 0.0000000       11 75930860 75930912 53 +      
ENSG00000198382 E013 18.6170499 0.0030218139 2.616899e-02 6.429137e-02 11 75961444 75961462 19 + 1.347 1.201 -0.510
ENSG00000198382 E014 32.2952953 0.0006826456 2.028719e-02 5.208424e-02 11 75961463 75961549 87 + 1.556 1.451 -0.360
ENSG00000198382 E015 0.2934659 0.0283481225 7.130348e-01   11 75979526 75980038 513 + 0.094 0.158 0.864
ENSG00000198382 E016 0.0000000       11 75980060 75980119 60 +      
ENSG00000198382 E017 35.5056245 0.0006148750 3.180256e-02 7.547446e-02 11 75983387 75983513 127 + 1.589 1.502 -0.300
ENSG00000198382 E018 0.1482932 0.0411597534 2.982763e-01   11 75983514 75983824 311 + 0.000 0.158 9.817
ENSG00000198382 E019 28.3499627 0.0014159993 9.156461e-02 1.775773e-01 11 76004005 76004089 85 + 1.490 1.415 -0.256
ENSG00000198382 E020 35.4376914 0.0006577436 1.799208e-01 3.010843e-01 11 76007534 76007621 88 + 1.570 1.531 -0.134
ENSG00000198382 E021 36.3352193 0.0006236120 4.001184e-02 9.106236e-02 11 76008807 76008867 61 + 1.595 1.514 -0.277
ENSG00000198382 E022 0.4751703 0.0205193293 3.149159e-01 4.576642e-01 11 76012927 76013102 176 + 0.094 0.274 1.865
ENSG00000198382 E023 57.1997779 0.0004871078 1.641028e-01 2.804987e-01 11 76016815 76016980 166 + 1.768 1.744 -0.081
ENSG00000198382 E024 41.2878689 0.0005812649 4.374066e-01 5.793687e-01 11 76065710 76065788 79 + 1.587 1.669 0.280
ENSG00000198382 E025 0.1515154 0.0428392471 7.998234e-01   11 76115900 76115923 24 + 0.094 0.000 -9.715
ENSG00000198382 E026 41.8640781 0.0023480765 4.129099e-01 5.564717e-01 11 76115924 76116015 92 + 1.592 1.680 0.300
ENSG00000198382 E027 0.6213751 0.0234812985 6.065681e-01 7.266735e-01 11 76133440 76133504 65 + 0.236 0.158 -0.718
ENSG00000198382 E028 2.4178614 0.0591082753 1.585298e-01 2.731588e-01 11 76137194 76137452 259 + 0.616 0.365 -1.249
ENSG00000198382 E029 345.2490378 0.0027942515 6.898675e-15 2.330896e-13 11 76140711 76144232 3522 + 2.439 2.643 0.680