ENSG00000198380

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361060 ENSG00000198380 HEK293_OSMI2_2hA HEK293_TMG_2hB GFPT1 protein_coding protein_coding 11.09152 5.383071 18.47931 0.3351831 0.1772895 1.777512 3.4344468 1.861222 5.894506 0.20550084 0.2671312 1.657835 0.31975417 0.3471667 0.31880000 -0.02836667 8.214519e-01 1.285382e-07 FALSE  
ENST00000674438 ENSG00000198380 HEK293_OSMI2_2hA HEK293_TMG_2hB GFPT1 protein_coding protein_coding 11.09152 5.383071 18.47931 0.3351831 0.1772895 1.777512 3.6127927 2.213700 5.395438 0.25469235 0.5468227 1.281449 0.35263750 0.4090333 0.29196667 -0.11706667 1.423934e-01 1.285382e-07 FALSE  
ENST00000674507 ENSG00000198380 HEK293_OSMI2_2hA HEK293_TMG_2hB GFPT1 protein_coding protein_coding 11.09152 5.383071 18.47931 0.3351831 0.1772895 1.777512 0.6732051 0.000000 1.415053 0.00000000 0.2567918 7.154872 0.04005833 0.0000000 0.07646667 0.07646667 1.285382e-07 1.285382e-07 FALSE  
MSTRG.18575.5 ENSG00000198380 HEK293_OSMI2_2hA HEK293_TMG_2hB GFPT1 protein_coding   11.09152 5.383071 18.47931 0.3351831 0.1772895 1.777512 3.2514822 1.283856 5.530058 0.08670527 0.7148072 2.098224 0.27434583 0.2397000 0.29943333 0.05973333 6.046814e-01 1.285382e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198380 E001 253.396470 0.0132257731 9.273145e-03 2.696748e-02 2 69319780 69322277 2498 - 2.315 2.471 0.522
ENSG00000198380 E002 336.065532 0.0045415518 9.058460e-06 6.080711e-05 2 69322278 69325422 3145 - 2.530 2.365 -0.550
ENSG00000198380 E003 144.150967 0.0017500846 1.282059e-01 2.316508e-01 2 69325423 69325977 555 - 2.107 2.166 0.196
ENSG00000198380 E004 88.096785 0.0004144316 3.591005e-06 2.641984e-05 2 69325978 69326233 256 - 1.851 2.037 0.623
ENSG00000198380 E005 101.225538 0.0030923970 2.867803e-03 9.876507e-03 2 69326914 69327075 162 - 1.929 2.068 0.465
ENSG00000198380 E006 104.782160 0.0002732009 2.183981e-03 7.792611e-03 2 69328271 69328438 168 - 1.950 2.065 0.384
ENSG00000198380 E007 110.595760 0.0003545649 1.976072e-01 3.232209e-01 2 69329297 69329424 128 - 1.996 2.046 0.166
ENSG00000198380 E008 102.225719 0.0003252645 1.060397e-01 1.996671e-01 2 69329684 69329798 115 - 1.956 2.019 0.212
ENSG00000198380 E009 127.049223 0.0008841388 2.504961e-01 3.865354e-01 2 69337898 69338055 158 - 2.056 2.099 0.144
ENSG00000198380 E010 100.900294 0.0003249604 5.545689e-01 6.835340e-01 2 69338445 69338565 121 - 1.976 1.955 -0.070
ENSG00000198380 E011 97.637999 0.0003998609 3.172870e-01 4.601475e-01 2 69342152 69342249 98 - 1.942 1.983 0.139
ENSG00000198380 E012 89.998069 0.0009211352 9.756428e-01 9.888009e-01 2 69345904 69345999 96 - 1.918 1.922 0.010
ENSG00000198380 E013 100.375009 0.0003427280 7.667094e-01 8.491169e-01 2 69348171 69348334 164 - 1.969 1.960 -0.032
ENSG00000198380 E014 74.021930 0.0011278092 8.439220e-01 9.028325e-01 2 69350078 69350183 106 - 1.837 1.829 -0.028
ENSG00000198380 E015 0.000000       2 69354259 69354312 54 -      
ENSG00000198380 E016 70.935030 0.0003694291 3.047199e-01 4.467544e-01 2 69354489 69354568 80 - 1.830 1.784 -0.155
ENSG00000198380 E017 62.805583 0.0016749885 3.866745e-01 5.308554e-01 2 69356496 69356557 62 - 1.778 1.733 -0.150
ENSG00000198380 E018 93.129418 0.0003104707 1.686992e-02 4.464561e-02 2 69358329 69358463 135 - 1.960 1.863 -0.328
ENSG00000198380 E019 57.475280 0.0004612640 1.797035e-02 4.707127e-02 2 69359268 69359326 59 - 1.764 1.640 -0.420
ENSG00000198380 E020 55.250943 0.0062496418 2.801829e-01 4.200084e-01 2 69363545 69363610 66 - 1.733 1.665 -0.234
ENSG00000198380 E021 58.793960 0.0075732666 2.059766e-02 5.274124e-02 2 69363611 69363670 60 - 1.780 1.622 -0.536
ENSG00000198380 E022 68.976580 0.0075037982 1.833867e-02 4.787189e-02 2 69370001 69370108 108 - 1.847 1.695 -0.516
ENSG00000198380 E023 0.000000       2 69371310 69371472 163 -      
ENSG00000198380 E024 61.877958 0.0004046018 2.546000e-05 1.540849e-04 2 69374006 69374113 108 - 1.816 1.593 -0.756
ENSG00000198380 E025 3.756852 0.0042089281 7.916970e-03 2.357026e-02 2 69382924 69383007 84 - 0.492 0.883 1.658
ENSG00000198380 E026 54.050910 0.0069938969 1.111242e-02 3.143612e-02 2 69387065 69387250 186 - 1.746 1.569 -0.602