ENSG00000198373

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359154 ENSG00000198373 HEK293_OSMI2_2hA HEK293_TMG_2hB WWP2 protein_coding protein_coding 13.42464 20.06026 9.921138 0.4606613 0.2782096 -1.015028 6.4980226 8.806610 5.9721403 1.27203924 0.07928573 -0.5595623 0.50247500 0.43663333 0.60256667 0.165933333 9.529566e-02 1.731686e-15 FALSE TRUE
ENST00000569174 ENSG00000198373 HEK293_OSMI2_2hA HEK293_TMG_2hB WWP2 protein_coding protein_coding 13.42464 20.06026 9.921138 0.4606613 0.2782096 -1.015028 0.6542652 1.067907 0.5903089 0.01494459 0.01058163 -0.8444556 0.05355417 0.05330000 0.05956667 0.006266667 8.290905e-01 1.731686e-15 FALSE TRUE
ENST00000569297 ENSG00000198373 HEK293_OSMI2_2hA HEK293_TMG_2hB WWP2 protein_coding processed_transcript 13.42464 20.06026 9.921138 0.4606613 0.2782096 -1.015028 1.5477525 5.971518 0.0000000 1.13660187 0.00000000 -9.2243678 0.08262500 0.30043333 0.00000000 -0.300433333 1.731686e-15 1.731686e-15 FALSE TRUE
MSTRG.12892.1 ENSG00000198373 HEK293_OSMI2_2hA HEK293_TMG_2hB WWP2 protein_coding   13.42464 20.06026 9.921138 0.4606613 0.2782096 -1.015028 0.8948111 1.331666 0.4109474 0.08094889 0.22254830 -1.6723142 0.06628750 0.06656667 0.04223333 -0.024333333 6.818992e-01 1.731686e-15 FALSE TRUE
MSTRG.12892.2 ENSG00000198373 HEK293_OSMI2_2hA HEK293_TMG_2hB WWP2 protein_coding   13.42464 20.06026 9.921138 0.4606613 0.2782096 -1.015028 2.2864451 2.144071 2.0656174 0.32927205 0.06320966 -0.0535254 0.18394583 0.10626667 0.20876667 0.102500000 1.176473e-02 1.731686e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198373 E001 0.8889039 0.2045726775 2.903943e-01 4.311908e-01 16 69762295 69762314 20 + 0.369 0.172 -1.461
ENSG00000198373 E002 4.0482272 0.0040584003 3.865710e-01 5.307514e-01 16 69762315 69762327 13 + 0.738 0.636 -0.427
ENSG00000198373 E003 4.6717924 0.0035487353 1.493873e-01 2.608241e-01 16 69762328 69762331 4 + 0.833 0.659 -0.706
ENSG00000198373 E004 14.0926949 0.0013603832 1.259583e-02 3.495998e-02 16 69762332 69762361 30 + 1.265 1.067 -0.706
ENSG00000198373 E005 33.7158394 0.0225248835 1.245539e-02 3.463077e-02 16 69762362 69762391 30 + 1.629 1.436 -0.661
ENSG00000198373 E006 0.3697384 0.0248758991 4.670457e-01 6.065620e-01 16 69774694 69774788 95 + 0.000 0.169 12.233
ENSG00000198373 E007 0.2214452 0.0393568240 1.000000e+00   16 69775079 69775140 62 + 0.000 0.093 11.082
ENSG00000198373 E008 0.0000000       16 69776187 69776188 2 +      
ENSG00000198373 E009 14.5273983 0.0013040220 1.216570e-02 3.392788e-02 16 69776189 69776241 53 + 1.286 1.093 -0.687
ENSG00000198373 E010 10.7975102 0.0017033657 5.163444e-01 6.509262e-01 16 69783032 69783152 121 + 1.069 1.030 -0.141
ENSG00000198373 E011 58.3054953 0.0105830942 3.268332e-03 1.105651e-02 16 69786996 69787080 85 + 1.844 1.680 -0.554
ENSG00000198373 E012 0.0000000       16 69787938 69788202 265 +      
ENSG00000198373 E013 101.3210522 0.0053249890 2.933015e-03 1.006632e-02 16 69798682 69798829 148 + 2.047 1.932 -0.383
ENSG00000198373 E014 0.0000000       16 69798865 69798954 90 +      
ENSG00000198373 E015 0.1472490 0.0429800943 2.438204e-01   16 69799046 69799173 128 + 0.160 0.000 -12.893
ENSG00000198373 E016 97.0576964 0.0042858835 1.894495e-03 6.897007e-03 16 69799174 69799295 122 + 2.029 1.913 -0.389
ENSG00000198373 E017 0.0000000       16 69799296 69799493 198 +      
ENSG00000198373 E018 0.2214452 0.0393568240 1.000000e+00   16 69827894 69828019 126 + 0.000 0.093 11.082
ENSG00000198373 E019 0.0000000       16 69838737 69838889 153 +      
ENSG00000198373 E020 98.0997939 0.0053350118 1.418855e-02 3.865314e-02 16 69840126 69840263 138 + 2.018 1.926 -0.307
ENSG00000198373 E021 71.6836810 0.0107342282 5.178260e-02 1.123319e-01 16 69842024 69842120 97 + 1.881 1.790 -0.307
ENSG00000198373 E022 0.0000000       16 69871713 69871803 91 +      
ENSG00000198373 E023 76.5033371 0.0019272997 1.917461e-02 4.971972e-02 16 69871804 69871931 128 + 1.901 1.824 -0.260
ENSG00000198373 E024 115.9542928 0.0002956988 1.814482e-06 1.424915e-05 16 69888039 69888249 211 + 2.116 1.985 -0.438
ENSG00000198373 E025 0.0000000       16 69890798 69890879 82 +      
ENSG00000198373 E026 0.0000000       16 69894962 69895149 188 +      
ENSG00000198373 E027 73.3842701 0.0003874505 1.969315e-04 9.506455e-04 16 69908761 69908850 90 + 1.918 1.790 -0.429
ENSG00000198373 E028 35.9231918 0.0006061178 4.353560e-01 5.775976e-01 16 69908851 69910250 1400 + 1.478 1.557 0.273
ENSG00000198373 E029 0.1451727 0.0428973008 2.441457e-01   16 69917583 69917708 126 + 0.160 0.000 -12.894
ENSG00000198373 E030 93.0350539 0.0003134608 2.460155e-05 1.495008e-04 16 69917709 69917883 175 + 2.020 1.891 -0.431
ENSG00000198373 E031 0.0000000       16 69924990 69925011 22 +      
ENSG00000198373 E032 0.2214452 0.0393568240 1.000000e+00   16 69925012 69925429 418 + 0.000 0.093 11.082
ENSG00000198373 E033 57.2218877 0.0109080599 4.279249e-03 1.392509e-02 16 69925430 69925484 55 + 1.835 1.668 -0.564
ENSG00000198373 E034 2.2980440 0.0310934277 8.394270e-02 1.657152e-01 16 69925980 69926096 117 + 0.660 0.385 -1.327
ENSG00000198373 E035 71.4188422 0.0004045333 1.294916e-04 6.565797e-04 16 69929448 69929529 82 + 1.911 1.777 -0.451
ENSG00000198373 E036 52.8125107 0.0004751057 2.510588e-02 6.209264e-02 16 69930130 69930165 36 + 1.748 1.666 -0.278
ENSG00000198373 E037 82.6813282 0.0003204895 1.085471e-01 2.034019e-01 16 69930166 69930258 93 + 1.908 1.874 -0.116
ENSG00000198373 E038 84.9912099 0.0003740254 1.376295e-02 3.768282e-02 16 69931152 69931227 76 + 1.943 1.875 -0.228
ENSG00000198373 E039 86.3443349 0.0014624212 7.749027e-04 3.168911e-03 16 69931509 69931580 72 + 1.981 1.871 -0.371
ENSG00000198373 E040 3.4581895 0.0046337057 7.309357e-02 1.484807e-01 16 69931581 69931801 221 + 0.772 0.528 -1.050
ENSG00000198373 E041 84.1967949 0.0003241691 3.193995e-02 7.573979e-02 16 69931802 69931890 89 + 1.929 1.874 -0.187
ENSG00000198373 E042 77.1346324 0.0019453794 2.187749e-01 3.489358e-01 16 69933970 69934050 81 + 1.787 1.878 0.305
ENSG00000198373 E043 89.4316617 0.0018285206 9.708926e-01 9.858220e-01 16 69934051 69934129 79 + 1.896 1.929 0.112
ENSG00000198373 E044 131.9110755 0.0038918721 5.630608e-01 6.905887e-01 16 69935853 69935986 134 + 2.082 2.089 0.025
ENSG00000198373 E045 152.3230784 0.0002828442 7.544317e-01 8.400819e-01 16 69936312 69936452 141 + 2.120 2.161 0.138
ENSG00000198373 E046 2.3551110 0.0064955185 3.435188e-01 4.875602e-01 16 69936453 69936796 344 + 0.369 0.557 0.960
ENSG00000198373 E047 0.6234634 0.0188848056 7.360763e-01 8.266687e-01 16 69936920 69937117 198 + 0.160 0.233 0.669
ENSG00000198373 E048 127.7670534 0.0002950051 3.251171e-02 7.682827e-02 16 69937118 69937238 121 + 1.999 2.104 0.351
ENSG00000198373 E049 121.1300131 0.0008009480 2.229634e-04 1.061834e-03 16 69937548 69937652 105 + 1.927 2.098 0.573
ENSG00000198373 E050 116.6456067 0.0003020045 1.380796e-03 5.243393e-03 16 69939027 69939123 97 + 1.927 2.075 0.497
ENSG00000198373 E051 102.6692799 0.0003214190 3.183301e-05 1.882179e-04 16 69939341 69939413 73 + 1.835 2.031 0.659
ENSG00000198373 E052 810.5956994 0.0036541443 2.198527e-15 7.942495e-14 16 69939841 69941741 1901 + 2.690 2.935 0.816