ENSG00000198363

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379454 ENSG00000198363 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPH protein_coding protein_coding 40.42837 11.21107 67.83533 0.2418298 2.266635 2.596039 11.1917859 3.8182970 15.8076073 0.16890374 0.4899802 2.0467567 0.31531250 0.340800000 0.23310000 -0.10770000 2.189412e-04 3.897012e-24 FALSE TRUE
ENST00000445642 ENSG00000198363 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPH protein_coding protein_coding 40.42837 11.21107 67.83533 0.2418298 2.266635 2.596039 0.7696075 1.1775963 0.7962873 0.10490359 0.7962873 -0.5586787 0.04060000 0.104866667 0.01153333 -0.09333333 5.026643e-02 3.897012e-24 FALSE TRUE
ENST00000518068 ENSG00000198363 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPH protein_coding protein_coding 40.42837 11.21107 67.83533 0.2418298 2.266635 2.596039 10.2154967 3.2862031 15.6584814 0.19276680 0.7741857 2.2489883 0.26850833 0.293266667 0.23123333 -0.06203333 1.919782e-01 3.897012e-24 FALSE TRUE
ENST00000519234 ENSG00000198363 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPH protein_coding protein_coding 40.42837 11.21107 67.83533 0.2418298 2.266635 2.596039 0.9221378 1.5783106 2.0512605 0.10924523 1.0613331 0.3760337 0.04039583 0.140500000 0.03086667 -0.10963333 3.540049e-01 3.897012e-24 FALSE TRUE
ENST00000541428 ENSG00000198363 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPH protein_coding protein_coding 40.42837 11.21107 67.83533 0.2418298 2.266635 2.596039 0.8625078 0.0000000 3.7605340 0.00000000 0.9634740 8.5586250 0.01235417 0.000000000 0.05566667 0.05566667 1.623636e-06 3.897012e-24 FALSE TRUE
MSTRG.31562.2 ENSG00000198363 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPH protein_coding   40.42837 11.21107 67.83533 0.2418298 2.266635 2.596039 2.6007102 0.0260551 4.6868632 0.01455241 0.3194438 7.0253503 0.04266667 0.002266667 0.06920000 0.06693333 2.195768e-14 3.897012e-24 FALSE TRUE
MSTRG.31562.30 ENSG00000198363 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPH protein_coding   40.42837 11.21107 67.83533 0.2418298 2.266635 2.596039 2.6625237 0.0000000 8.2253306 0.00000000 0.7465627 9.6856828 0.03761250 0.000000000 0.12090000 0.12090000 3.897012e-24 3.897012e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198363 E001 608.9951208 0.0001115964 1.105832e-52 7.817035e-50 8 61500556 61503013 2458 - 2.613 2.883 0.897
ENSG00000198363 E002 91.6689664 0.0003663335 3.372095e-01 4.810817e-01 8 61503014 61503115 102 - 1.863 1.837 -0.088
ENSG00000198363 E003 63.2755279 0.0004765975 1.320087e-01 2.369089e-01 8 61503116 61503153 38 - 1.714 1.645 -0.234
ENSG00000198363 E004 48.7595472 0.0004537036 1.519857e-01 2.643740e-01 8 61503154 61503164 11 - 1.604 1.528 -0.260
ENSG00000198363 E005 197.6394249 0.0014903370 1.761693e-02 4.630686e-02 8 61503165 61503509 345 - 2.203 2.133 -0.235
ENSG00000198363 E006 2.9828063 0.0938409818 7.454185e-02 1.508103e-01 8 61517013 61517527 515 - 0.433 0.791 1.599
ENSG00000198363 E007 111.4326491 0.0002773751 2.654739e-01 4.035274e-01 8 61517528 61517661 134 - 1.950 1.922 -0.096
ENSG00000198363 E008 90.5120407 0.0003457891 4.597496e-01 5.998456e-01 8 61518032 61518123 92 - 1.857 1.841 -0.052
ENSG00000198363 E009 107.1511363 0.0041193584 1.652417e-01 2.819888e-01 8 61525977 61526112 136 - 1.937 1.879 -0.194
ENSG00000198363 E010 115.7900517 0.0020585858 6.422956e-03 1.972267e-02 8 61548071 61548208 138 - 1.981 1.864 -0.392
ENSG00000198363 E011 109.8406021 0.0002969511 1.092594e-02 3.098309e-02 8 61553031 61553120 90 - 1.956 1.860 -0.324
ENSG00000198363 E012 93.5005199 0.0007900287 3.235857e-01 4.668910e-01 8 61555924 61556022 99 - 1.874 1.846 -0.094
ENSG00000198363 E013 107.9384297 0.0005636401 1.041173e-01 1.967650e-01 8 61562744 61562880 137 - 1.940 1.886 -0.182
ENSG00000198363 E014 87.2948223 0.0003399550 1.144062e-02 3.221113e-02 8 61567168 61567256 89 - 1.859 1.748 -0.373
ENSG00000198363 E015 77.3143259 0.0080590596 3.846112e-02 8.821346e-02 8 61567257 61567318 62 - 1.809 1.681 -0.434
ENSG00000198363 E016 0.3666179 0.0298318241 2.432458e-01 3.779862e-01 8 61576601 61576771 171 - 0.058 0.242 2.387
ENSG00000198363 E017 72.6653204 0.0010937665 9.651825e-03 2.790680e-02 8 61576772 61576858 87 - 1.784 1.652 -0.448
ENSG00000198363 E018 0.4470576 0.0216514035 4.595292e-01 5.996447e-01 8 61582999 61583535 537 - 0.109 0.241 1.382
ENSG00000198363 E019 68.7342622 0.0040967132 3.710034e-03 1.232646e-02 8 61583944 61584029 86 - 1.767 1.590 -0.602
ENSG00000198363 E020 6.8376918 0.0683726968 1.072933e-02 3.052010e-02 8 61606461 61607322 862 - 0.684 1.128 1.698
ENSG00000198363 E021 59.3308144 0.0027022817 6.425767e-02 1.337959e-01 8 61618978 61619019 42 - 1.694 1.590 -0.353
ENSG00000198363 E022 29.0753327 0.0029166761 2.639670e-14 8.160534e-13 8 61623710 61624536 827 - 1.203 1.765 1.934
ENSG00000198363 E023 2.4464389 0.0402577442 1.406964e-01 2.489704e-01 8 61624537 61624538 2 - 0.385 0.675 1.388
ENSG00000198363 E024 24.2593807 0.0023813821 3.534526e-16 1.417754e-14 8 61624539 61624602 64 - 1.093 1.724 2.190
ENSG00000198363 E025 364.5465168 0.0101875451 1.497596e-08 1.787294e-07 8 61624603 61625305 703 - 2.377 2.693 1.052
ENSG00000198363 E026 171.5248396 0.0045005421 2.885960e-07 2.680737e-06 8 61625306 61625644 339 - 2.071 2.322 0.839
ENSG00000198363 E027 126.8699515 0.0022271096 3.179783e-05 1.880416e-04 8 61625645 61625909 265 - 1.955 2.153 0.666
ENSG00000198363 E028 175.8477550 0.0005185224 6.946646e-02 1.424728e-01 8 61625910 61626140 231 - 2.125 2.208 0.278
ENSG00000198363 E029 169.7855988 0.0012900125 4.430580e-01 5.846265e-01 8 61626141 61626280 140 - 2.118 2.168 0.169
ENSG00000198363 E030 1.0246279 0.1125627985 2.777720e-01 4.173784e-01 8 61633125 61633376 252 - 0.300 0.000 -12.078
ENSG00000198363 E031 145.7298451 0.0003180393 4.852204e-01 6.231359e-01 8 61633683 61633727 45 - 2.063 2.057 -0.020
ENSG00000198363 E032 126.7236474 0.0054433452 6.130111e-01 7.318237e-01 8 61637947 61637968 22 - 1.992 2.043 0.169
ENSG00000198363 E033 166.1712618 0.0006384139 8.184977e-01 8.852840e-01 8 61637969 61638003 35 - 2.112 2.141 0.098
ENSG00000198363 E034 0.5954526 0.0183841792 5.428721e-01 6.735663e-01 8 61638004 61638046 43 - 0.196 0.000 -11.587
ENSG00000198363 E035 167.8442457 0.0003340033 7.954949e-01 8.694090e-01 8 61638322 61638360 39 - 2.118 2.130 0.038
ENSG00000198363 E036 110.4061741 0.0006501573 4.664001e-01 6.059410e-01 8 61638361 61638363 3 - 1.942 1.930 -0.041
ENSG00000198363 E037 179.1858003 0.0002310864 4.605006e-01 6.005374e-01 8 61642888 61642920 33 - 2.149 2.144 -0.016
ENSG00000198363 E038 220.3480059 0.0002246181 7.610681e-05 4.095660e-04 8 61643386 61643433 48 - 2.256 2.146 -0.366
ENSG00000198363 E039 210.7654414 0.0001820316 7.993780e-06 5.429700e-05 8 61643945 61644001 57 - 2.240 2.110 -0.435
ENSG00000198363 E040 234.6642590 0.0002787696 2.721348e-06 2.056693e-05 8 61644600 61644632 33 - 2.287 2.155 -0.440
ENSG00000198363 E041 298.2356691 0.0001855994 3.009850e-09 4.082531e-08 8 61646750 61646878 129 - 2.393 2.243 -0.501
ENSG00000198363 E042 284.0524935 0.0002835196 4.608187e-10 7.261143e-09 8 61651050 61651124 75 - 2.374 2.207 -0.560
ENSG00000198363 E043 0.4418608 0.0248590741 8.084937e-01 8.783603e-01 8 61651125 61651431 307 - 0.155 0.000 -11.170
ENSG00000198363 E044 257.1928876 0.0001634136 6.178431e-09 7.929579e-08 8 61653568 61653660 93 - 2.331 2.171 -0.534
ENSG00000198363 E045 74.6307543 0.0257989704 7.986800e-01 8.715369e-01 8 61656128 61661813 5686 - 1.764 1.822 0.195
ENSG00000198363 E046 6.5388860 0.0025412246 3.518050e-01 4.960214e-01 8 61661814 61661926 113 - 0.807 0.674 -0.542
ENSG00000198363 E047 0.1472490 0.0437855716 1.000000e+00   8 61664725 61665139 415 - 0.058 0.000 -9.555
ENSG00000198363 E048 0.5922303 0.0179974886 6.629565e-01 7.711340e-01 8 61665140 61665606 467 - 0.155 0.241 0.797
ENSG00000198363 E049 0.1515154 0.0429914767 1.000000e+00   8 61668234 61668275 42 - 0.058 0.000 -9.557
ENSG00000198363 E050 0.9651910 0.0121989077 3.266639e-01 4.701069e-01 8 61675259 61675877 619 - 0.196 0.396 1.384
ENSG00000198363 E051 2.7366851 0.0057400378 5.541033e-01 6.831262e-01 8 61675878 61676319 442 - 0.476 0.599 0.575
ENSG00000198363 E052 1.6724181 0.0104307954 9.010090e-01 9.408538e-01 8 61680524 61680967 444 - 0.358 0.396 0.213
ENSG00000198363 E053 184.5138316 0.0002023045 1.555715e-05 9.891776e-05 8 61680968 61681036 69 - 2.184 2.048 -0.455
ENSG00000198363 E054 7.2004675 0.0420992909 4.981456e-01 6.346609e-01 8 61682439 61682483 45 - 0.843 0.736 -0.424
ENSG00000198363 E055 0.0000000       8 61683553 61684038 486 -      
ENSG00000198363 E056 219.6247203 0.0029636109 1.772045e-05 1.111986e-04 8 61684039 61684188 150 - 2.263 2.101 -0.543
ENSG00000198363 E057 1.1855920 0.0168167201 4.407569e-01 5.824240e-01 8 61684189 61684190 2 - 0.234 0.396 1.065
ENSG00000198363 E058 1.0393897 0.0119328363 2.315859e-01 3.643621e-01 8 61684485 61684700 216 - 0.300 0.000 -12.385
ENSG00000198363 E059 0.2998086 0.0292933699 2.449258e-01   8 61687415 61687700 286 - 0.058 0.241 2.381
ENSG00000198363 E060 0.4417471 0.7190878863 1.000000e+00 1.000000e+00 8 61689673 61689849 177 - 0.154 0.000 -8.872
ENSG00000198363 E061 1.8980160 0.1068222478 4.954225e-01 6.322248e-01 8 61713943 61714268 326 - 0.359 0.510 0.798
ENSG00000198363 E062 161.2405696 0.0031009813 1.278415e-04 6.493252e-04 8 61714269 61714640 372 - 2.129 1.967 -0.543