ENSG00000198276

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354216 ENSG00000198276 HEK293_OSMI2_2hA HEK293_TMG_2hB UCKL1 protein_coding protein_coding 42.63413 58.34104 32.53149 3.212734 0.893233 -0.8424783 22.635309 41.659089 13.847478 1.1550184 0.4080062 -1.58831284 0.51829583 0.71636667 0.42633333 -0.29003333 8.212547e-11 8.212547e-11 FALSE TRUE
ENST00000430743 ENSG00000198276 HEK293_OSMI2_2hA HEK293_TMG_2hB UCKL1 protein_coding protein_coding 42.63413 58.34104 32.53149 3.212734 0.893233 -0.8424783 3.992175 2.820270 2.969281 0.3241555 0.6709256 0.07402445 0.09554583 0.04853333 0.09123333 0.04270000 2.573422e-01 8.212547e-11 FALSE FALSE
ENST00000492660 ENSG00000198276 HEK293_OSMI2_2hA HEK293_TMG_2hB UCKL1 protein_coding retained_intron 42.63413 58.34104 32.53149 3.212734 0.893233 -0.8424783 2.184827 1.643252 1.828755 0.1800056 0.3726074 0.15342244 0.05479583 0.02816667 0.05573333 0.02756667 7.379796e-02 8.212547e-11 TRUE FALSE
ENST00000607800 ENSG00000198276 HEK293_OSMI2_2hA HEK293_TMG_2hB UCKL1 protein_coding miRNA 42.63413 58.34104 32.53149 3.212734 0.893233 -0.8424783 3.441273 1.727589 4.576750 1.7275893 0.8084558 1.40038505 0.07679167 0.02683333 0.14020000 0.11336667 8.495746e-02 8.212547e-11   FALSE
MSTRG.21002.13 ENSG00000198276 HEK293_OSMI2_2hA HEK293_TMG_2hB UCKL1 protein_coding   42.63413 58.34104 32.53149 3.212734 0.893233 -0.8424783 3.063631 4.741066 2.688807 0.2343428 0.1074322 -0.81592930 0.07252500 0.08170000 0.08260000 0.00090000 9.985418e-01 8.212547e-11 TRUE TRUE
MSTRG.21002.16 ENSG00000198276 HEK293_OSMI2_2hA HEK293_TMG_2hB UCKL1 protein_coding   42.63413 58.34104 32.53149 3.212734 0.893233 -0.8424783 2.785323 1.159708 3.047709 0.2062224 0.6672386 1.38630229 0.07249583 0.01963333 0.09460000 0.07496667 3.794323e-05 8.212547e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198276 E001 0.0000000       20 63933967 63933968 2 -      
ENSG00000198276 E002 1.9843284 0.0076042148 6.098474e-01 7.292422e-01 20 63933969 63935981 2013 - 0.501 0.409 -0.472
ENSG00000198276 E003 0.1451727 0.0431155502 1.719081e-01   20 63938827 63939291 465 - 0.188 0.000 -10.610
ENSG00000198276 E004 0.2924217 0.0290785164 4.118621e-02   20 63939292 63939828 537 - 0.319 0.000 -11.784
ENSG00000198276 E005 2.3195217 0.0232778916 7.411728e-02 1.501245e-01 20 63939829 63939836 8 - 0.188 0.547 2.220
ENSG00000198276 E006 2.5409669 0.0080267412 5.016701e-02 1.094589e-01 20 63939837 63939839 3 - 0.188 0.572 2.333
ENSG00000198276 E007 17.3017986 0.0010458543 1.438782e-02 3.910491e-02 20 63939840 63939902 63 - 0.985 1.236 0.904
ENSG00000198276 E008 19.2496840 0.0009643100 1.552850e-01 2.687731e-01 20 63939903 63939903 1 - 1.129 1.260 0.464
ENSG00000198276 E009 124.9659251 0.0002507533 4.134433e-01 5.569297e-01 20 63939904 63939923 20 - 2.003 2.031 0.095
ENSG00000198276 E010 283.0212965 0.0002242969 2.413578e-01 3.757808e-01 20 63939924 63940055 132 - 2.358 2.385 0.091
ENSG00000198276 E011 8.9978653 0.0019227673 3.814439e-01 5.257356e-01 20 63940097 63940149 53 - 1.009 0.905 -0.389
ENSG00000198276 E012 379.5111515 0.0001434456 8.185568e-03 2.425443e-02 20 63940150 63940306 157 - 2.461 2.516 0.182
ENSG00000198276 E013 286.5681696 0.0031235123 7.200849e-03 2.174649e-02 20 63940378 63940485 108 - 2.308 2.406 0.326
ENSG00000198276 E014 293.1376109 0.0018903352 8.202027e-05 4.375562e-04 20 63940594 63940716 123 - 2.294 2.420 0.421
ENSG00000198276 E015 246.5432069 0.0006281933 5.575076e-02 1.192644e-01 20 63940794 63940856 63 - 2.274 2.327 0.176
ENSG00000198276 E016 276.4328691 0.0004785813 2.946101e-02 7.089542e-02 20 63940950 63941043 94 - 2.323 2.379 0.187
ENSG00000198276 E017 10.2482074 0.0016327089 1.977432e-03 7.156994e-03 20 63941044 63941109 66 - 1.209 0.883 -1.191
ENSG00000198276 E018 175.4443145 0.0005092966 7.170713e-04 2.960210e-03 20 63941110 63941135 26 - 2.086 2.197 0.372
ENSG00000198276 E019 218.4249838 0.0004160124 6.418655e-05 3.519217e-04 20 63941136 63941208 73 - 2.175 2.292 0.394
ENSG00000198276 E020 34.6265941 0.0260458389 6.189079e-06 4.315907e-05 20 63941209 63941464 256 - 1.775 1.326 -1.538
ENSG00000198276 E021 23.3238659 0.0089789861 6.061292e-06 4.234419e-05 20 63941465 63941609 145 - 1.572 1.190 -1.326
ENSG00000198276 E022 7.4178255 0.0025605711 1.925742e-04 9.321054e-04 20 63942470 63942492 23 - 1.146 0.708 -1.664
ENSG00000198276 E023 133.6288436 0.0017341656 4.272327e-02 9.603915e-02 20 63943653 63943669 17 - 1.989 2.070 0.272
ENSG00000198276 E024 26.9286342 0.0113641523 2.807661e-12 6.404507e-11 20 63943747 63944021 275 - 1.733 1.152 -2.010
ENSG00000198276 E025 250.1182128 0.0001696545 1.690465e-01 2.869502e-01 20 63944397 63944458 62 - 2.297 2.331 0.114
ENSG00000198276 E026 427.8474171 0.0001780488 8.496150e-01 9.066723e-01 20 63944545 63944734 190 - 2.561 2.555 -0.019
ENSG00000198276 E027 254.1193252 0.0022137561 3.516024e-01 4.958463e-01 20 63945651 63945696 46 - 2.356 2.323 -0.110
ENSG00000198276 E028 214.0532816 0.0017670972 1.516184e-01 2.638561e-01 20 63945697 63945722 26 - 2.295 2.245 -0.166
ENSG00000198276 E029 380.7810200 0.0001323244 3.659705e-04 1.642550e-03 20 63945805 63945914 110 - 2.561 2.488 -0.246
ENSG00000198276 E030 267.1302488 0.0001867907 6.612736e-04 2.756840e-03 20 63945915 63945975 61 - 2.415 2.331 -0.282
ENSG00000198276 E031 19.9546717 0.0011951207 7.288795e-04 3.002676e-03 20 63945976 63946160 185 - 1.440 1.167 -0.957
ENSG00000198276 E032 282.1699741 0.0001661613 2.017399e-02 5.184699e-02 20 63946161 63946267 107 - 2.419 2.362 -0.191
ENSG00000198276 E033 326.2844076 0.0016940758 5.029441e-02 1.096864e-01 20 63946453 63946640 188 - 2.483 2.425 -0.194
ENSG00000198276 E034 65.9881385 0.0005053788 3.766521e-01 5.209686e-01 20 63946641 63946643 3 - 1.783 1.737 -0.154
ENSG00000198276 E035 10.0129253 0.0053120911 3.234526e-01 4.667845e-01 20 63948225 63948475 251 - 1.053 0.936 -0.431
ENSG00000198276 E036 7.1670293 0.2405184111 4.685152e-01 6.079285e-01 20 63950759 63951126 368 - 0.936 0.811 -0.477
ENSG00000198276 E037 180.6110630 0.0039615340 1.590737e-01 2.738822e-01 20 63956260 63956467 208 - 2.228 2.167 -0.203