ENSG00000198270

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355445 ENSG00000198270 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM116 protein_coding protein_coding 4.560194 3.316001 6.194826 0.5811983 0.5544113 0.899602 0.5523971 0.32356649 0.7368199 0.19660967 0.07827341 1.1627860 0.12269583 0.104300000 0.12166667 0.01736667 0.755914924 0.002104596 FALSE TRUE
ENST00000437003 ENSG00000198270 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM116 protein_coding processed_transcript 4.560194 3.316001 6.194826 0.5811983 0.5544113 0.899602 0.7809414 0.83250651 0.3807873 0.14432099 0.03476880 -1.1083042 0.19948750 0.267600000 0.06263333 -0.20496667 0.002104596 0.002104596 FALSE FALSE
ENST00000549537 ENSG00000198270 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM116 protein_coding protein_coding 4.560194 3.316001 6.194826 0.5811983 0.5544113 0.899602 0.6140024 0.55997888 0.8851124 0.04122947 0.13705176 0.6511603 0.13260000 0.178500000 0.14220000 -0.03630000 0.778228522 0.002104596 FALSE TRUE
ENST00000550831 ENSG00000198270 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM116 protein_coding protein_coding 4.560194 3.316001 6.194826 0.5811983 0.5544113 0.899602 0.7525098 0.36217239 1.2228066 0.36217239 0.61205869 1.7279035 0.15145000 0.080866667 0.19086667 0.11000000 0.640917063 0.002104596 FALSE TRUE
ENST00000552374 ENSG00000198270 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM116 protein_coding protein_coding 4.560194 3.316001 6.194826 0.5811983 0.5544113 0.899602 0.4583760 0.46483557 0.3529275 0.24298585 0.35292754 -0.3877465 0.10612917 0.142933333 0.06293333 -0.08000000 0.529730585 0.002104596 FALSE TRUE
ENST00000552839 ENSG00000198270 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM116 protein_coding processed_transcript 4.560194 3.316001 6.194826 0.5811983 0.5544113 0.899602 0.2908092 0.06907326 0.7674382 0.06907326 0.42004867 3.2974662 0.05335417 0.025200000 0.11690000 0.09170000 0.591392971 0.002104596   FALSE
MSTRG.8041.9 ENSG00000198270 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM116 protein_coding   4.560194 3.316001 6.194826 0.5811983 0.5544113 0.899602 0.1820510 0.01896834 0.6578054 0.01896834 0.27196227 4.5268791 0.03252500 0.004233333 0.10980000 0.10556667 0.011092498 0.002104596 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198270 E001 0.0000000       12 111931282 111931297 16 -      
ENSG00000198270 E002 0.0000000       12 111931298 111931298 1 -      
ENSG00000198270 E003 4.2102249 0.0475363841 1.509480e-01 2.629558e-01 12 111931299 111931369 71 - 0.580 0.835 1.057
ENSG00000198270 E004 4.4995261 0.0464343989 4.162292e-01 5.596049e-01 12 111931370 111931379 10 - 0.660 0.808 0.606
ENSG00000198270 E005 18.9880687 0.0012484743 3.567083e-02 8.294139e-02 12 111931380 111931521 142 - 1.212 1.413 0.701
ENSG00000198270 E006 20.6133674 0.0009597500 6.440769e-03 1.976839e-02 12 111931522 111931639 118 - 1.226 1.465 0.835
ENSG00000198270 E007 29.8442942 0.0007532376 1.008439e-01 1.917494e-01 12 111931640 111931827 188 - 1.432 1.574 0.488
ENSG00000198270 E008 0.2934659 0.0275921158 7.769702e-01   12 111932585 111932585 1 - 0.099 0.151 0.701
ENSG00000198270 E009 20.5554918 0.0011022259 2.843637e-02 6.888456e-02 12 111932586 111932659 74 - 1.245 1.446 0.701
ENSG00000198270 E010 0.9890372 0.0139434910 6.349494e-01 7.493351e-01 12 111932660 111932731 72 - 0.247 0.351 0.704
ENSG00000198270 E011 27.1810741 0.0007890146 7.712150e-01 8.522932e-01 12 111933886 111934030 145 - 1.448 1.472 0.082
ENSG00000198270 E012 9.9929869 0.0017700816 7.644417e-03 2.288469e-02 12 111934031 111936691 2661 - 1.130 0.883 -0.912
ENSG00000198270 E013 14.9356841 0.0013722210 4.316500e-02 9.684597e-02 12 111936692 111936741 50 - 1.263 1.128 -0.479
ENSG00000198270 E014 12.5667628 0.0016136372 1.030732e-01 1.951539e-01 12 111936742 111936754 13 - 1.184 1.071 -0.405
ENSG00000198270 E015 18.4210478 0.0079120265 1.059732e-02 3.020401e-02 12 111936755 111936830 76 - 1.365 1.177 -0.661
ENSG00000198270 E016 14.6308040 0.0015860946 4.728520e-02 1.043457e-01 12 111937160 111937174 15 - 1.251 1.115 -0.484
ENSG00000198270 E017 19.7876287 0.0058143283 4.561799e-02 1.013307e-01 12 111937175 111937243 69 - 1.375 1.253 -0.425
ENSG00000198270 E018 0.0000000       12 111938047 111938160 114 -      
ENSG00000198270 E019 15.9775765 0.0022216279 3.050596e-01 4.471003e-01 12 111938161 111938183 23 - 1.257 1.213 -0.157
ENSG00000198270 E020 15.3173898 0.0115052034 6.756997e-01 7.808896e-01 12 111938184 111938210 27 - 1.219 1.230 0.038
ENSG00000198270 E021 0.0000000       12 111943261 111943264 4 -      
ENSG00000198270 E022 20.2704723 0.0232854721 5.837374e-01 7.077816e-01 12 111943265 111943369 105 - 1.336 1.335 -0.005
ENSG00000198270 E023 0.0000000       12 111965592 111965594 3 -      
ENSG00000198270 E024 6.1850044 0.0031892139 9.787864e-02 1.872822e-01 12 111965595 111965759 165 - 0.747 0.987 0.924
ENSG00000198270 E025 3.1010257 0.0379013270 2.577359e-01 3.949086e-01 12 111978736 111978787 52 - 0.683 0.539 -0.636
ENSG00000198270 E026 0.1451727 0.0449310336 7.609564e-01   12 111991744 111991757 14 - 0.099 0.000 -9.823
ENSG00000198270 E027 19.4870148 0.0011174041 1.795465e-02 4.703730e-02 12 111991758 111991813 56 - 1.375 1.235 -0.489
ENSG00000198270 E028 20.4696961 0.0010152425 2.708622e-02 6.616896e-02 12 111991814 111991889 76 - 1.389 1.265 -0.430
ENSG00000198270 E029 0.1515154 0.0451168692 7.607024e-01   12 112003569 112003799 231 - 0.099 0.000 -9.824
ENSG00000198270 E030 7.8639582 0.0022994463 1.825497e-01 3.044107e-01 12 112003800 112003863 64 - 0.997 0.883 -0.427
ENSG00000198270 E031 19.3555719 0.0010563152 5.084959e-04 2.191528e-03 12 112005257 112005303 47 - 1.393 1.155 -0.836
ENSG00000198270 E032 0.0000000       12 112005602 112005686 85 -      
ENSG00000198270 E033 0.0000000       12 112005687 112005943 257 -      
ENSG00000198270 E034 0.0000000       12 112005944 112005948 5 -      
ENSG00000198270 E035 1.0017226 0.0139701164 6.357112e-01 7.499129e-01 12 112005949 112006126 178 - 0.247 0.351 0.704
ENSG00000198270 E036 44.6979144 0.0741227954 6.810387e-06 4.703465e-05 12 112010425 112013001 2577 - 1.298 1.898 2.050
ENSG00000198270 E037 25.0565080 0.0022257853 2.514049e-02 6.216929e-02 12 112013002 112013185 184 - 1.459 1.338 -0.422
ENSG00000198270 E038 1.6438130 0.2408424760 1.052449e-01 1.984683e-01 12 112013442 112013525 84 - 0.549 0.151 -2.607