ENSG00000198265

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358691 ENSG00000198265 HEK293_OSMI2_2hA HEK293_TMG_2hB HELZ protein_coding protein_coding 6.966937 2.742488 10.01508 0.1181928 0.4314261 1.864806 4.420135 2.63458883 5.309327 0.09950695 0.2011233 1.008200 0.7347958 0.961400000 0.5305667 -0.4308333 1.245365e-20 1.245365e-20 FALSE TRUE
ENST00000580168 ENSG00000198265 HEK293_OSMI2_2hA HEK293_TMG_2hB HELZ protein_coding protein_coding 6.966937 2.742488 10.01508 0.1181928 0.4314261 1.864806 2.057320 0.01120555 3.546057 0.01120555 0.2834074 7.389693 0.2051375 0.003766667 0.3556000 0.3518333 1.413643e-15 1.245365e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198265 E001 808.3086958 0.0047126650 9.444281e-23 8.162366e-21 17 67070444 67077928 7485 - 2.728 3.082 1.179
ENSG00000198265 E002 8.1755051 0.0213699810 1.139585e-12 2.768188e-11 17 67077929 67077971 43 - 0.379 1.409 4.146
ENSG00000198265 E003 94.5641332 0.0161276913 3.823480e-09 5.088134e-08 17 67077972 67078586 615 - 1.715 2.245 1.782
ENSG00000198265 E004 89.2791040 0.0021129150 2.296958e-06 1.763461e-05 17 67086829 67087081 253 - 1.791 2.108 1.064
ENSG00000198265 E005 121.9226435 0.0002944864 2.969421e-01 4.382298e-01 17 67107169 67107685 517 - 1.987 2.136 0.497
ENSG00000198265 E006 60.7969960 0.0008520282 9.585041e-01 9.779996e-01 17 67108492 67108726 235 - 1.698 1.812 0.385
ENSG00000198265 E007 95.4039590 0.0003490462 4.831201e-01 6.211868e-01 17 67109116 67109686 571 - 1.901 1.985 0.282
ENSG00000198265 E008 40.7954543 0.0006536022 4.087812e-03 1.338837e-02 17 67114324 67114403 80 - 1.579 1.505 -0.251
ENSG00000198265 E009 68.1256675 0.0003636223 2.858314e-03 9.848480e-03 17 67120405 67120612 208 - 1.790 1.756 -0.115
ENSG00000198265 E010 61.2360579 0.0033584709 2.024362e-02 5.199219e-02 17 67122970 67123160 191 - 1.740 1.717 -0.078
ENSG00000198265 E011 31.0389809 0.0105892821 4.321772e-03 1.404633e-02 17 67123963 67124014 52 - 1.481 1.337 -0.499
ENSG00000198265 E012 0.4482035 0.0255064243 3.795874e-01 5.238513e-01 17 67128495 67128650 156 - 0.183 0.000 -11.172
ENSG00000198265 E013 56.8657796 0.0004838833 8.813988e-03 2.581847e-02 17 67128651 67128855 205 - 1.713 1.685 -0.096
ENSG00000198265 E014 66.9734256 0.0015975799 8.053341e-03 2.391500e-02 17 67135970 67136198 229 - 1.785 1.760 -0.085
ENSG00000198265 E015 54.4337037 0.0084053607 4.687766e-01 6.081554e-01 17 67137931 67138114 184 - 1.670 1.736 0.223
ENSG00000198265 E016 39.9597753 0.0472730754 2.395251e-01 3.735588e-01 17 67145743 67145890 148 - 1.558 1.548 -0.033
ENSG00000198265 E017 43.1217006 0.0220170138 3.467096e-02 8.101722e-02 17 67148569 67148714 146 - 1.607 1.524 -0.286
ENSG00000198265 E018 38.7344718 0.0008141824 8.364771e-03 2.470004e-02 17 67149867 67149985 119 - 1.558 1.497 -0.211
ENSG00000198265 E019 39.6414349 0.0024554231 8.660649e-02 1.699735e-01 17 67151046 67151224 179 - 1.554 1.552 -0.008
ENSG00000198265 E020 30.2118272 0.0007089850 2.322343e-03 8.220330e-03 17 67160261 67160362 102 - 1.466 1.348 -0.407
ENSG00000198265 E021 5.2144640 0.0032794399 6.458859e-03 1.981718e-02 17 67160363 67160365 3 - 0.818 0.451 -1.612
ENSG00000198265 E022 42.2080015 0.0052854225 7.198040e-05 3.898028e-04 17 67160897 67161076 180 - 1.619 1.434 -0.632
ENSG00000198265 E023 34.9221400 0.0006158901 1.122503e-06 9.221809e-06 17 67166478 67166608 131 - 1.548 1.298 -0.864
ENSG00000198265 E024 27.7449906 0.0007561377 4.447482e-07 3.973600e-06 17 67167463 67167525 63 - 1.460 1.139 -1.125
ENSG00000198265 E025 37.3913642 0.0006216983 2.285375e-04 1.085596e-03 17 67167526 67167711 186 - 1.556 1.414 -0.489
ENSG00000198265 E026 26.8331037 0.0006869079 5.525029e-04 2.356045e-03 17 67167712 67167796 85 - 1.425 1.256 -0.588
ENSG00000198265 E027 1.1856066 0.0105448714 3.216856e-01 4.649393e-01 17 67176321 67176669 349 - 0.346 0.206 -1.004
ENSG00000198265 E028 48.2346794 0.0004744773 3.105998e-06 2.315619e-05 17 67178659 67178926 268 - 1.672 1.497 -0.596
ENSG00000198265 E029 0.0000000       17 67179596 67179736 141 -      
ENSG00000198265 E030 1.3693873 0.0096181692 7.387215e-01 8.285325e-01 17 67188218 67188318 101 - 0.346 0.346 -0.004
ENSG00000198265 E031 63.6390983 0.0005953230 3.181107e-12 7.194977e-11 17 67188319 67188616 298 - 1.811 1.529 -0.957
ENSG00000198265 E032 40.6652683 0.0112306735 4.836644e-04 2.097536e-03 17 67189589 67189696 108 - 1.606 1.422 -0.629
ENSG00000198265 E033 26.8840129 0.0602271095 1.837011e-02 4.794271e-02 17 67190157 67190188 32 - 1.444 1.200 -0.850
ENSG00000198265 E034 45.5598583 0.0030403926 1.227755e-09 1.788501e-08 17 67190189 67190355 167 - 1.677 1.348 -1.129
ENSG00000198265 E035 32.3183104 0.0006325000 2.345909e-08 2.697574e-07 17 67193967 67194042 76 - 1.528 1.193 -1.165
ENSG00000198265 E036 28.3693896 0.0007455745 1.344401e-08 1.618226e-07 17 67195419 67195470 52 - 1.481 1.099 -1.340
ENSG00000198265 E037 0.0000000       17 67200613 67201128 516 -      
ENSG00000198265 E038 24.6704080 0.0007584306 6.978981e-08 7.303469e-07 17 67201129 67201185 57 - 1.422 1.031 -1.386
ENSG00000198265 E039 22.5554567 0.0008267859 2.227023e-04 1.060750e-03 17 67203319 67203379 61 - 1.361 1.139 -0.781
ENSG00000198265 E040 21.8664556 0.0010484373 8.208109e-05 4.378436e-04 17 67203380 67203443 64 - 1.354 1.099 -0.902
ENSG00000198265 E041 0.1515154 0.0426125215 1.000000e+00   17 67215788 67215898 111 - 0.070 0.000 -9.549
ENSG00000198265 E042 18.3227121 0.0038688256 3.022837e-03 1.033344e-02 17 67215899 67215935 37 - 1.269 1.078 -0.683
ENSG00000198265 E043 16.0152013 0.0014703676 5.081096e-03 1.615137e-02 17 67218595 67218607 13 - 1.213 1.031 -0.655
ENSG00000198265 E044 44.1669876 0.0006128277 2.057775e-10 3.439253e-09 17 67218608 67218822 215 - 1.660 1.336 -1.114
ENSG00000198265 E045 19.8410264 0.0009325861 1.088353e-06 8.963140e-06 17 67239433 67239489 57 - 1.337 0.950 -1.391
ENSG00000198265 E046 0.1451727 0.0431393393 1.000000e+00   17 67239490 67239800 311 - 0.070 0.000 -9.547
ENSG00000198265 E047 18.4166735 0.0010417835 6.408701e-09 8.197348e-08 17 67243784 67243839 56 - 1.323 0.768 -2.042
ENSG00000198265 E048 13.3484394 0.0013517665 1.126711e-06 9.253165e-06 17 67245148 67245196 49 - 1.189 0.667 -1.986
ENSG00000198265 E049 0.1472490 0.0439111188 1.000000e+00   17 67245815 67245989 175 - 0.070 0.000 -9.545