ENSG00000198252

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354586 ENSG00000198252 HEK293_OSMI2_2hA HEK293_TMG_2hB STYX protein_coding protein_coding 9.531357 6.176253 13.07441 1.222785 0.6392368 1.080711 1.7544873 0.3504982 4.8380930 0.3504982 0.3701922 3.74935348 0.16871667 0.08686667 0.37173333 0.28486667 1.000151e-01 3.999946e-08 FALSE TRUE
ENST00000442123 ENSG00000198252 HEK293_OSMI2_2hA HEK293_TMG_2hB STYX protein_coding protein_coding 9.531357 6.176253 13.07441 1.222785 0.6392368 1.080711 1.6513945 0.8545540 0.9033652 0.4500443 0.6199457 0.07923582 0.14555000 0.11710000 0.06703333 -0.05006667 8.697876e-01 3.999946e-08 FALSE TRUE
ENST00000556861 ENSG00000198252 HEK293_OSMI2_2hA HEK293_TMG_2hB STYX protein_coding processed_transcript 9.531357 6.176253 13.07441 1.222785 0.6392368 1.080711 0.3728441 1.3885005 0.0000000 0.6801339 0.0000000 -7.12773700 0.06664583 0.19633333 0.00000000 -0.19633333 3.999946e-08 3.999946e-08   FALSE
MSTRG.9549.1 ENSG00000198252 HEK293_OSMI2_2hA HEK293_TMG_2hB STYX protein_coding   9.531357 6.176253 13.07441 1.222785 0.6392368 1.080711 5.7526306 3.5827007 7.3329541 0.4407131 0.3689924 1.03129184 0.61909583 0.59973333 0.56120000 -0.03853333 8.526089e-01 3.999946e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198252 E001 0.2924217 0.0275527523 6.064109e-01   14 52730165 52730165 1 + 0.148 0.000 -8.585
ENSG00000198252 E002 0.8857980 0.0136968632 9.016711e-02 1.753769e-01 14 52730166 52730179 14 + 0.345 0.000 -12.375
ENSG00000198252 E003 6.4258888 0.0025926536 4.514936e-01 5.924400e-01 14 52730180 52730210 31 + 0.873 0.795 -0.307
ENSG00000198252 E004 57.8796023 0.0009058056 8.983962e-01 9.392074e-01 14 52730211 52730458 248 + 1.736 1.752 0.055
ENSG00000198252 E005 53.0300006 0.0004819170 6.036283e-01 7.243800e-01 14 52730459 52730531 73 + 1.690 1.740 0.169
ENSG00000198252 E006 0.0000000       14 52731594 52731712 119 +      
ENSG00000198252 E007 43.8773061 0.0005514553 1.678591e-01 2.854090e-01 14 52744852 52744884 33 + 1.642 1.588 -0.186
ENSG00000198252 E008 45.2949473 0.0005371247 6.869824e-01 7.894045e-01 14 52746426 52746479 54 + 1.636 1.638 0.004
ENSG00000198252 E009 61.8151516 0.0004486486 2.480622e-01 3.836422e-01 14 52750683 52750780 98 + 1.745 1.822 0.260
ENSG00000198252 E010 39.0375804 0.0006622333 1.009613e-02 2.899804e-02 14 52756551 52756611 61 + 1.521 1.691 0.581
ENSG00000198252 E011 39.5352234 0.0005902078 2.021798e-02 5.194245e-02 14 52757319 52757355 37 + 1.526 1.682 0.532
ENSG00000198252 E012 39.1619541 0.0007647840 5.040318e-03 1.604074e-02 14 52757743 52757782 40 + 1.507 1.692 0.628
ENSG00000198252 E013 46.9737846 0.0024376557 4.915325e-03 1.569489e-02 14 52757874 52757924 51 + 1.584 1.764 0.609
ENSG00000198252 E014 48.1627992 0.0066253101 5.255862e-01 6.589297e-01 14 52759682 52759754 73 + 1.640 1.697 0.194
ENSG00000198252 E015 65.1981645 0.0004017522 3.455324e-01 4.896408e-01 14 52768840 52768933 94 + 1.799 1.779 -0.066
ENSG00000198252 E016 65.5454215 0.0004283394 3.174259e-01 4.603031e-01 14 52771033 52771183 151 + 1.804 1.783 -0.072
ENSG00000198252 E017 220.4549701 0.0002900815 2.175334e-22 1.809089e-20 14 52771184 52773615 2432 + 2.377 2.153 -0.748
ENSG00000198252 E018 140.9325987 0.0215974285 2.801742e-02 6.805085e-02 14 52773616 52774989 1374 + 2.051 2.248 0.656
ENSG00000198252 E019 0.1472490 0.0460889229 1.000000e+00   14 52790517 52790561 45 + 0.080 0.000 -9.602