ENSG00000198242

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000422514 ENSG00000198242 HEK293_OSMI2_2hA HEK293_TMG_2hB RPL23A protein_coding protein_coding 1040.838 1629.942 804.989 175.5608 33.06818 -1.01777 653.9003 1214.9366 421.5429 106.2145 9.27120 -1.5271071 0.6019167 0.7484333 0.5248000 -0.2236333 2.567738e-11 6.176842e-14 FALSE TRUE
ENST00000578181 ENSG00000198242 HEK293_OSMI2_2hA HEK293_TMG_2hB RPL23A protein_coding protein_coding 1040.838 1629.942 804.989 175.5608 33.06818 -1.01777 367.6366 394.6827 357.3880 68.2436 27.37351 -0.1431982 0.3770500 0.2390667 0.4427333 0.2036667 5.708279e-09 6.176842e-14 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198242 E001 21.832547 0.0017646548 4.491903e-01 5.903868e-01 17 28719985 28719990 6 + 1.240 1.315 0.262
ENSG00000198242 E002 13258.643392 0.0008126243 7.248099e-05 3.921326e-04 17 28719991 28720030 40 + 4.093 4.049 -0.144
ENSG00000198242 E003 29.555301 0.0006898173 2.581469e-11 5.026223e-10 17 28720079 28720213 135 + 1.696 1.279 -1.435
ENSG00000198242 E004 16.400670 0.0207977264 1.066358e-03 4.188904e-03 17 28720244 28720263 20 + 1.408 1.058 -1.238
ENSG00000198242 E005 35.890076 0.0005825096 1.382330e-01 2.456321e-01 17 28720264 28720298 35 + 1.572 1.491 -0.279
ENSG00000198242 E006 43.675346 0.0005011869 4.899742e-02 1.073757e-01 17 28720299 28720328 30 + 1.668 1.568 -0.342
ENSG00000198242 E007 47.635933 0.0009555134 3.955578e-01 5.393651e-01 17 28720329 28720413 85 + 1.663 1.628 -0.120
ENSG00000198242 E008 32.878543 0.0514251528 7.168515e-01 8.123934e-01 17 28720414 28720430 17 + 1.495 1.469 -0.087
ENSG00000198242 E009 6.618553 0.0742285205 4.698272e-05 2.665050e-04 17 28720550 28720568 19 + 1.226 0.558 -2.597
ENSG00000198242 E010 15.599635 0.0184929174 1.121600e-07 1.129272e-06 17 28720569 28720704 136 + 1.501 0.947 -1.966
ENSG00000198242 E011 13.668399 0.0015261834 6.534132e-02 1.356096e-01 17 28720705 28720706 2 + 1.227 1.062 -0.590
ENSG00000198242 E012 18540.513193 0.0008314156 6.051439e-04 2.552210e-03 17 28720707 28720890 184 + 4.230 4.198 -0.109
ENSG00000198242 E013 94.153549 0.0032514723 7.417221e-29 1.129558e-26 17 28720891 28721261 371 + 2.232 1.733 -1.675
ENSG00000198242 E014 18602.177118 0.0004945722 2.382810e-02 5.946024e-02 17 28722723 28722899 177 + 4.190 4.214 0.080
ENSG00000198242 E015 27.340812 0.0138517348 1.755582e-04 8.592421e-04 17 28723300 28723428 129 + 1.606 1.294 -1.076
ENSG00000198242 E016 31.171169 0.0010168903 2.297840e-05 1.404572e-04 17 28723429 28723570 142 + 1.633 1.371 -0.899
ENSG00000198242 E017 10918.842116 0.0009192589 3.146806e-03 1.069774e-02 17 28723571 28723640 70 + 3.943 3.987 0.146
ENSG00000198242 E018 19.636806 0.0012461089 8.449662e-04 3.419777e-03 17 28723641 28723681 41 + 1.433 1.178 -0.893
ENSG00000198242 E019 25.358293 0.0007558109 8.591621e-05 4.559008e-04 17 28723682 28723800 119 + 1.548 1.283 -0.915
ENSG00000198242 E020 4223.037023 0.0016546602 4.019110e-20 2.593352e-18 17 28723867 28724359 493 + 3.411 3.605 0.644