ENSG00000198231

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389924 ENSG00000198231 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX42 protein_coding protein_coding 49.05436 40.6444 60.34985 0.9699641 0.7395376 0.5701778 6.111538 9.0415207 9.9156699 1.1391427 1.2333841 0.1330043 0.12928333 0.22276667 0.164633333 -0.05813333 4.435577e-01 2.862823e-26 FALSE TRUE
ENST00000579511 ENSG00000198231 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX42 protein_coding retained_intron 49.05436 40.6444 60.34985 0.9699641 0.7395376 0.5701778 4.661688 1.9141904 8.0963028 0.3962604 0.9289225 2.0747925 0.09097917 0.04750000 0.134133333 0.08663333 4.188876e-03 2.862823e-26 FALSE FALSE
ENST00000579539 ENSG00000198231 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX42 protein_coding retained_intron 49.05436 40.6444 60.34985 0.9699641 0.7395376 0.5701778 1.304409 4.6866976 0.3450018 2.4779156 0.1565849 -3.7257485 0.03061667 0.11620000 0.005666667 -0.11053333 4.651082e-01 2.862823e-26 FALSE TRUE
ENST00000580108 ENSG00000198231 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX42 protein_coding retained_intron 49.05436 40.6444 60.34985 0.9699641 0.7395376 0.5701778 3.576375 0.6434055 6.8482097 0.1072547 0.2231900 3.3917815 0.06841667 0.01586667 0.113533333 0.09766667 7.462833e-22 2.862823e-26 FALSE TRUE
MSTRG.14907.10 ENSG00000198231 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX42 protein_coding   49.05436 40.6444 60.34985 0.9699641 0.7395376 0.5701778 6.642584 0.6133985 9.2118546 0.6133985 0.8928219 3.8868304 0.12815417 0.01516667 0.152333333 0.13716667 4.198724e-02 2.862823e-26 FALSE TRUE
MSTRG.14907.7 ENSG00000198231 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX42 protein_coding   49.05436 40.6444 60.34985 0.9699641 0.7395376 0.5701778 19.091306 19.6210936 15.1614629 1.9683478 1.9948846 -0.3717803 0.39993750 0.48103333 0.251066667 -0.22996667 1.845783e-03 2.862823e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198231 E001 0.4407149 0.0215575539 6.742758e-01 7.797745e-01 17 63773603 63773815 213 + 0.193 0.139 -0.565
ENSG00000198231 E002 4.8874812 0.0033580442 2.493857e-02 6.174422e-02 17 63773816 63773861 46 + 0.871 0.605 -1.087
ENSG00000198231 E003 4.8874812 0.0033580442 2.493857e-02 6.174422e-02 17 63773862 63773862 1 + 0.871 0.605 -1.087
ENSG00000198231 E004 5.8129313 0.0029419109 2.187655e-02 5.542185e-02 17 63773863 63773883 21 + 0.932 0.680 -0.996
ENSG00000198231 E005 7.6167012 0.0023282465 8.785041e-02 1.718519e-01 17 63773884 63773915 32 + 0.998 0.849 -0.564
ENSG00000198231 E006 14.3862046 0.0018332179 1.771775e-03 6.509530e-03 17 63773916 63774066 151 + 1.283 1.050 -0.831
ENSG00000198231 E007 7.6366755 0.0968418992 1.257131e-01 2.281661e-01 17 63774067 63774091 25 + 1.035 0.796 -0.904
ENSG00000198231 E008 3.0375390 0.0050747177 1.777876e-02 4.666037e-02 17 63774092 63774169 78 + 0.738 0.400 -1.564
ENSG00000198231 E009 2.5528038 0.0058257864 1.614794e-02 4.305368e-02 17 63774170 63774188 19 + 0.692 0.329 -1.787
ENSG00000198231 E010 5.0324660 0.0039141974 3.260897e-02 7.701679e-02 17 63774189 63774189 1 + 0.887 0.644 -0.980
ENSG00000198231 E011 91.1994869 0.0085386341 1.996059e-02 5.140273e-02 17 63774190 63774376 187 + 2.001 1.919 -0.277
ENSG00000198231 E012 21.2275725 0.0008923858 4.615629e-01 6.015005e-01 17 63775108 63775178 71 + 1.348 1.346 -0.004
ENSG00000198231 E013 66.3390850 0.0062377061 3.377908e-02 7.931171e-02 17 63787034 63787035 2 + 1.859 1.790 -0.235
ENSG00000198231 E014 67.1359210 0.0080185833 5.971598e-02 1.261416e-01 17 63787036 63787037 2 + 1.861 1.798 -0.211
ENSG00000198231 E015 278.7891467 0.0011359581 3.844391e-10 6.151253e-09 17 63787038 63787270 233 + 2.497 2.385 -0.372
ENSG00000198231 E016 214.7981831 0.0001871464 2.292382e-13 6.195218e-12 17 63792412 63792485 74 + 2.391 2.265 -0.418
ENSG00000198231 E017 187.5653000 0.0001966328 1.784142e-12 4.194676e-11 17 63792486 63792528 43 + 2.334 2.203 -0.436
ENSG00000198231 E018 162.3796685 0.0014537640 1.307311e-06 1.058855e-05 17 63792529 63792562 34 + 2.261 2.155 -0.356
ENSG00000198231 E019 196.5129071 0.0023341312 7.743929e-07 6.589104e-06 17 63798038 63798099 62 + 2.348 2.233 -0.385
ENSG00000198231 E020 35.1355359 0.0006111220 3.424491e-27 4.505275e-25 17 63798100 63798381 282 + 1.762 1.064 -2.421
ENSG00000198231 E021 14.5707314 0.0012280376 2.577989e-06 1.958819e-05 17 63799480 63799523 44 + 1.336 0.952 -1.381
ENSG00000198231 E022 154.7579888 0.0057443927 1.179651e-03 4.572321e-03 17 63799589 63799625 37 + 2.238 2.142 -0.320
ENSG00000198231 E023 16.1037282 0.0020972191 1.401154e-07 1.384325e-06 17 63800151 63800176 26 + 1.384 0.952 -1.546
ENSG00000198231 E024 50.6746582 0.0179624661 2.212103e-08 2.558506e-07 17 63800177 63800467 291 + 1.864 1.431 -1.474
ENSG00000198231 E025 294.6481869 0.0024483863 1.457896e-03 5.500119e-03 17 63800468 63800617 150 + 2.493 2.449 -0.148
ENSG00000198231 E026 4.4598791 0.0061853190 1.646027e-03 6.108060e-03 17 63805044 63805070 27 + 0.887 0.461 -1.826
ENSG00000198231 E027 249.8197785 0.0008839947 1.402955e-03 5.316137e-03 17 63805071 63805175 105 + 2.414 2.385 -0.096
ENSG00000198231 E028 3.7730561 0.0050621868 3.174222e-06 2.361464e-05 17 63805176 63805287 112 + 0.887 0.139 -4.148
ENSG00000198231 E029 18.6657952 0.0009484349 1.544594e-11 3.118605e-10 17 63805508 63806534 1027 + 1.470 0.933 -1.914
ENSG00000198231 E030 238.1295947 0.0002020943 2.447714e-04 1.153398e-03 17 63806535 63806654 120 + 2.394 2.364 -0.100
ENSG00000198231 E031 295.7143016 0.0006641231 1.180680e-05 7.715701e-05 17 63807724 63807900 177 + 2.496 2.448 -0.161
ENSG00000198231 E032 301.1781289 0.0010362323 3.330760e-03 1.123700e-02 17 63808820 63808948 129 + 2.491 2.471 -0.065
ENSG00000198231 E033 272.9373982 0.0002096592 1.497905e-02 4.044087e-02 17 63809560 63809659 100 + 2.438 2.440 0.007
ENSG00000198231 E034 3.0042270 0.0060132110 8.817134e-02 1.723306e-01 17 63810263 63810512 250 + 0.692 0.461 -1.049
ENSG00000198231 E035 207.3815521 0.0002004095 2.562517e-02 6.317626e-02 17 63810513 63810560 48 + 2.321 2.321 0.001
ENSG00000198231 E036 292.7084579 0.0004715237 2.574877e-01 3.946081e-01 17 63811076 63811173 98 + 2.454 2.484 0.097
ENSG00000198231 E037 3.5868898 0.0095215283 9.865562e-01 9.956527e-01 17 63811174 63811271 98 + 0.639 0.680 0.174
ENSG00000198231 E038 12.4614571 0.0773675535 1.976726e-01 3.233083e-01 17 63811281 63811931 651 + 1.193 1.046 -0.529
ENSG00000198231 E039 459.9935330 0.0002190117 2.890828e-01 4.297587e-01 17 63811932 63812208 277 + 2.648 2.685 0.124
ENSG00000198231 E040 198.3401959 0.0001856717 6.106091e-01 7.299257e-01 17 63813228 63813271 44 + 2.267 2.336 0.229
ENSG00000198231 E041 394.2560417 0.0001331704 8.805165e-01 9.273655e-01 17 63813272 63813454 183 + 2.569 2.628 0.194
ENSG00000198231 E042 348.0840364 0.0001571287 9.002816e-01 9.403728e-01 17 63815563 63815673 111 + 2.515 2.573 0.193
ENSG00000198231 E043 2.5884155 0.0966651528 6.177165e-01 7.354703e-01 17 63815674 63815970 297 + 0.580 0.516 -0.296
ENSG00000198231 E044 2.1077207 0.0087916881 1.956817e-01 3.208138e-01 17 63816589 63816867 279 + 0.579 0.400 -0.888
ENSG00000198231 E045 340.9168729 0.0012325013 2.886871e-01 4.292984e-01 17 63816868 63816966 99 + 2.496 2.578 0.274
ENSG00000198231 E046 1.7682679 0.0080598899 1.239233e-01 2.255658e-01 17 63816967 63816967 1 + 0.265 0.563 1.660
ENSG00000198231 E047 2.6582185 0.0058083866 8.823083e-01 9.286458e-01 17 63816968 63817072 105 + 0.546 0.563 0.075
ENSG00000198231 E048 3.4685606 0.0885549711 3.554059e-01 4.997519e-01 17 63817073 63817345 273 + 0.716 0.562 -0.663
ENSG00000198231 E049 3.9365689 0.0051317803 9.835022e-01 9.937436e-01 17 63817346 63817693 348 + 0.666 0.713 0.196
ENSG00000198231 E050 1826.8350790 0.0026134614 4.645643e-19 2.661656e-17 17 63817694 63818934 1241 + 3.133 3.372 0.794
ENSG00000198231 E051 423.7791778 0.0052592456 8.638679e-19 4.812031e-17 17 63818935 63819448 514 + 2.396 2.795 1.330