ENSG00000198218

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357496 ENSG00000198218 HEK293_OSMI2_2hA HEK293_TMG_2hB QRICH1 protein_coding protein_coding 61.58563 64.54719 60.88758 3.223789 1.269438 -0.08419287 5.498798 4.170503 7.524755 0.7517710 0.6629437 0.8498841 0.09088333 0.06613333 0.1233333 0.0572000 8.194566e-02 2.67111e-08 FALSE TRUE
ENST00000395443 ENSG00000198218 HEK293_OSMI2_2hA HEK293_TMG_2hB QRICH1 protein_coding protein_coding 61.58563 64.54719 60.88758 3.223789 1.269438 -0.08419287 40.677853 50.023962 35.463113 3.1825685 0.4599150 -0.4961817 0.65713333 0.77390000 0.5832333 -0.1906667 2.671110e-08 2.67111e-08 FALSE TRUE
ENST00000489642 ENSG00000198218 HEK293_OSMI2_2hA HEK293_TMG_2hB QRICH1 protein_coding retained_intron 61.58563 64.54719 60.88758 3.223789 1.269438 -0.08419287 8.511984 6.643351 9.246495 0.7411024 0.4049064 0.4763849 0.13941250 0.10393333 0.1517333 0.0478000 1.327956e-01 2.67111e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198218 E001 299.5246242 0.0045120591 3.147236e-11 6.037816e-10 3 49029707 49029930 224 - 2.278 2.541 0.876
ENSG00000198218 E002 216.4511769 0.0048072816 1.046386e-09 1.546293e-08 3 49029931 49029931 1 - 2.138 2.402 0.882
ENSG00000198218 E003 790.9782838 0.0013547632 2.630755e-16 1.076433e-14 3 49029932 49030211 280 - 2.767 2.937 0.568
ENSG00000198218 E004 503.8638864 0.0009995240 3.808446e-22 3.078066e-20 3 49030212 49030374 163 - 2.540 2.752 0.707
ENSG00000198218 E005 894.1267295 0.0001103168 2.328945e-18 1.225588e-16 3 49030375 49030644 270 - 2.866 2.973 0.358
ENSG00000198218 E006 594.2006143 0.0004881555 2.511903e-05 1.522207e-04 3 49032183 49032273 91 - 2.713 2.785 0.240
ENSG00000198218 E007 35.3974656 0.0257753509 3.278843e-07 3.009570e-06 3 49032274 49032618 345 - 1.797 1.308 -1.673
ENSG00000198218 E008 4.6897950 0.0061070434 8.608584e-04 3.476446e-03 3 49032619 49032621 3 - 0.986 0.533 -1.851
ENSG00000198218 E009 649.4389187 0.0013502206 8.334404e-03 2.462880e-02 3 49032622 49032773 152 - 2.762 2.816 0.180
ENSG00000198218 E010 55.3104673 0.0004943845 1.353934e-20 9.293432e-19 3 49032774 49032898 125 - 1.963 1.517 -1.510
ENSG00000198218 E011 56.4804958 0.0005168101 1.348574e-16 5.714233e-15 3 49032899 49033046 148 - 1.950 1.558 -1.326
ENSG00000198218 E012 30.3761108 0.0020615901 3.760516e-07 3.408048e-06 3 49033047 49033082 36 - 1.663 1.330 -1.145
ENSG00000198218 E013 32.2688559 0.0014893421 1.864245e-08 2.186280e-07 3 49033083 49033119 37 - 1.699 1.346 -1.211
ENSG00000198218 E014 445.9679982 0.0001535024 1.846471e-01 3.070319e-01 3 49033120 49033228 109 - 2.622 2.643 0.069
ENSG00000198218 E015 2.8117205 0.0055926203 6.625231e-01 7.708130e-01 3 49033229 49033830 602 - 0.528 0.596 0.315
ENSG00000198218 E016 417.2767742 0.0001308887 1.162087e-01 2.145686e-01 3 49044390 49044504 115 - 2.590 2.616 0.086
ENSG00000198218 E017 479.9329036 0.0001734984 6.960903e-01 7.965336e-01 3 49046425 49046579 155 - 2.665 2.669 0.013
ENSG00000198218 E018 457.1702586 0.0001423523 7.475149e-03 2.244962e-02 3 49047069 49047246 178 - 2.676 2.627 -0.163
ENSG00000198218 E019 429.1188973 0.0015783637 1.515813e-02 4.084579e-02 3 49056862 49057043 182 - 2.658 2.590 -0.225
ENSG00000198218 E020 1099.6732078 0.0011276528 1.805512e-15 6.599438e-14 3 49057044 49057791 748 - 3.113 2.965 -0.490
ENSG00000198218 E021 298.9994881 0.0010979692 8.330189e-10 1.252981e-08 3 49057792 49057890 99 - 2.556 2.394 -0.540
ENSG00000198218 E022 1.9573486 0.0073918385 5.154040e-01 6.500782e-01 3 49076707 49076708 2 - 0.528 0.416 -0.559
ENSG00000198218 E023 369.6430267 0.0005107166 2.783337e-23 2.543631e-21 3 49076709 49076872 164 - 2.675 2.464 -0.703
ENSG00000198218 E024 319.6806942 0.0050307990 3.487713e-08 3.876881e-07 3 49076873 49077038 166 - 2.618 2.395 -0.743
ENSG00000198218 E025 0.2214452 0.0409775475 6.735332e-01   3 49086883 49087089 207 - 0.000 0.103 9.643
ENSG00000198218 E026 0.0000000       3 49092284 49092293 10 -      
ENSG00000198218 E027 28.5926173 0.0006979533 3.426133e-04 1.550649e-03 3 49092397 49092456 60 - 1.586 1.351 -0.806
ENSG00000198218 E028 10.6316677 0.1201625854 4.563185e-01 5.967664e-01 3 49093255 49093611 357 - 1.147 0.983 -0.596
ENSG00000198218 E029 0.7320925 0.0633386456 7.511536e-03 2.254396e-02 3 49093894 49093911 18 - 0.473 0.000 -13.236
ENSG00000198218 E030 170.3036444 0.0235067512 9.156479e-03 2.667283e-02 3 49093912 49094071 160 - 2.338 2.128 -0.701
ENSG00000198218 E031 30.9496902 0.0244967583 2.210311e-01 3.516496e-01 3 49094137 49094230 94 - 1.564 1.437 -0.436
ENSG00000198218 E032 2.1745300 0.0067044018 2.140974e-02 5.445114e-02 3 49094337 49094363 27 - 0.695 0.316 -1.881