ENSG00000198176

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375370 ENSG00000198176 HEK293_OSMI2_2hA HEK293_TMG_2hB TFDP1 protein_coding protein_coding 110.6067 114.0355 140.3302 4.350942 1.46072 0.2993182 25.314059 12.1362771 53.388575 0.7404483 1.37413976 2.1362871 0.21302083 0.10696667 0.380600000 0.27363333 1.125107e-26 1.125107e-26 FALSE TRUE
ENST00000408980 ENSG00000198176 HEK293_OSMI2_2hA HEK293_TMG_2hB TFDP1 protein_coding protein_coding 110.6067 114.0355 140.3302 4.350942 1.46072 0.2993182 3.988962 0.0000000 8.173587 0.0000000 2.06277965 9.6765894 0.03177917 0.00000000 0.057966667 0.05796667 1.344488e-20 1.125107e-26 FALSE TRUE
ENST00000464794 ENSG00000198176 HEK293_OSMI2_2hA HEK293_TMG_2hB TFDP1 protein_coding processed_transcript 110.6067 114.0355 140.3302 4.350942 1.46072 0.2993182 27.977525 41.3387936 27.978809 3.5916679 1.09413104 -0.5629951 0.25837500 0.36586667 0.199266667 -0.16660000 6.507788e-03 1.125107e-26   FALSE
MSTRG.9109.17 ENSG00000198176 HEK293_OSMI2_2hA HEK293_TMG_2hB TFDP1 protein_coding   110.6067 114.0355 140.3302 4.350942 1.46072 0.2993182 6.154572 7.1153989 0.300443 1.4003089 0.07728044 -4.5205704 0.06029167 0.06173333 0.002133333 -0.05960000 6.050289e-17 1.125107e-26 FALSE TRUE
MSTRG.9109.19 ENSG00000198176 HEK293_OSMI2_2hA HEK293_TMG_2hB TFDP1 protein_coding   110.6067 114.0355 140.3302 4.350942 1.46072 0.2993182 16.449661 21.5540220 1.284034 2.9244943 1.28403410 -4.0586787 0.16286667 0.18763333 0.009233333 -0.17840000 1.826709e-02 1.125107e-26 FALSE TRUE
MSTRG.9109.6 ENSG00000198176 HEK293_OSMI2_2hA HEK293_TMG_2hB TFDP1 protein_coding   110.6067 114.0355 140.3302 4.350942 1.46072 0.2993182 7.210339 0.5490153 22.849682 0.5490153 1.18073986 5.3537738 0.05595833 0.00450000 0.162900000 0.15840000 5.590283e-03 1.125107e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198176 E001 0.0000000       13 113584396 113584569 174 +      
ENSG00000198176 E002 0.0000000       13 113584570 113584588 19 +      
ENSG00000198176 E003 0.7490443 0.0922628439 8.604989e-02 1.690682e-01 13 113584589 113584633 45 + 0.337 0.000 -10.613
ENSG00000198176 E004 33.0618619 0.0183046999 1.884419e-01 3.117679e-01 13 113584634 113584720 87 + 1.551 1.460 -0.312
ENSG00000198176 E005 39.7068895 0.0080504349 1.249306e-01 2.270308e-01 13 113584721 113584730 10 + 1.624 1.545 -0.270
ENSG00000198176 E006 11.3817232 0.0135276136 5.200429e-11 9.630553e-10 13 113584731 113584732 2 + 1.267 0.280 -4.273
ENSG00000198176 E007 19.2321233 0.0178925890 2.730399e-15 9.765260e-14 13 113584733 113584742 10 + 1.486 0.373 -4.447
ENSG00000198176 E008 33.2274460 0.0204476745 1.337346e-19 8.154368e-18 13 113584743 113584752 10 + 1.715 0.571 -4.223
ENSG00000198176 E009 121.5235399 0.2365720077 7.938846e-06 5.395869e-05 13 113584753 113584798 46 + 2.265 1.177 -3.706
ENSG00000198176 E010 248.3392482 0.0131525589 1.898864e-02 4.930903e-02 13 113584799 113584888 90 + 2.425 2.311 -0.380
ENSG00000198176 E011 3.2732509 0.0071273935 7.183147e-01 8.134531e-01 13 113584993 113585000 8 + 0.580 0.665 0.372
ENSG00000198176 E012 5.3339550 0.0030882387 4.602665e-01 6.003134e-01 13 113585001 113585047 47 + 0.736 0.866 0.515
ENSG00000198176 E013 5.2931806 0.0167249713 1.293284e-01 2.332395e-01 13 113585048 113585064 17 + 0.676 0.917 0.959
ENSG00000198176 E014 4.5557776 0.0453674477 7.365987e-02 1.493868e-01 13 113585065 113585106 42 + 0.580 0.895 1.289
ENSG00000198176 E015 4.7426933 0.0449732684 8.021569e-02 1.598870e-01 13 113585107 113585149 43 + 0.606 0.916 1.252
ENSG00000198176 E016 3.7914834 0.0780582315 4.345039e-01 5.768706e-01 13 113585246 113585250 5 + 0.580 0.752 0.731
ENSG00000198176 E017 4.7794764 0.1191342574 5.665117e-01 6.934863e-01 13 113585251 113585272 22 + 0.675 0.824 0.602
ENSG00000198176 E018 5.1126962 0.1023417884 5.203814e-01 6.543478e-01 13 113585273 113585285 13 + 0.696 0.852 0.623
ENSG00000198176 E019 7.8180690 0.0126392216 1.571865e-01 2.713477e-01 13 113585286 113585332 47 + 0.835 1.042 0.776
ENSG00000198176 E020 19.1409552 0.0009585419 3.451663e-02 8.074423e-02 13 113585333 113585425 93 + 1.203 1.406 0.710
ENSG00000198176 E021 11.5571161 0.0015812999 4.617081e-02 1.023511e-01 13 113585426 113585427 2 + 0.984 1.215 0.833
ENSG00000198176 E022 2.7573963 0.0142966243 5.835632e-01 7.076563e-01 13 113585428 113585579 152 + 0.580 0.515 -0.304
ENSG00000198176 E023 20.0533713 0.0010455185 7.579244e-05 4.080901e-04 13 113585580 113585677 98 + 1.149 1.490 1.192
ENSG00000198176 E024 265.0348971 0.0053796112 7.460906e-04 3.064582e-03 13 113585774 113585799 26 + 2.339 2.511 0.572
ENSG00000198176 E025 480.1980210 0.0018819535 2.323672e-14 7.242722e-13 13 113585800 113585849 50 + 2.566 2.798 0.772
ENSG00000198176 E026 309.2145754 0.0059350806 2.623478e-57 2.401015e-54 13 113585966 113586180 215 + 2.054 2.781 2.425
ENSG00000198176 E027 353.0194129 0.0001640493 3.143514e-12 7.115896e-11 13 113610996 113611062 67 + 2.576 2.475 -0.338
ENSG00000198176 E028 505.5006412 0.0001058172 1.071036e-16 4.589561e-15 13 113623180 113623286 107 + 2.730 2.631 -0.331
ENSG00000198176 E029 580.1518378 0.0003312555 1.782129e-08 2.097013e-07 13 113631623 113631744 122 + 2.776 2.720 -0.189
ENSG00000198176 E030 5.9169886 0.0034977695 8.026247e-01 8.742703e-01 13 113631745 113631905 161 + 0.835 0.838 0.010
ENSG00000198176 E031 789.2046948 0.0001042767 7.334598e-22 5.746558e-20 13 113633120 113633285 166 + 2.921 2.831 -0.300
ENSG00000198176 E032 0.7374030 0.0156454884 4.398744e-01 5.816127e-01 13 113633286 113633287 2 + 0.287 0.162 -1.046
ENSG00000198176 E033 671.3832936 0.0003218915 3.601601e-11 6.840912e-10 13 113633890 113634033 144 + 2.843 2.776 -0.224
ENSG00000198176 E034 427.8988627 0.0008183758 5.608187e-04 2.387752e-03 13 113634534 113634602 69 + 2.637 2.601 -0.122
ENSG00000198176 E035 655.4685111 0.0001216906 3.724597e-02 8.594250e-02 13 113635977 113636128 152 + 2.805 2.814 0.032
ENSG00000198176 E036 789.9514869 0.0001170228 3.543144e-01 4.985909e-01 13 113636534 113636700 167 + 2.878 2.905 0.091
ENSG00000198176 E037 8.1722557 0.0034062549 5.679778e-06 3.991753e-05 13 113637151 113637242 92 + 1.103 0.514 -2.368
ENSG00000198176 E038 26.5132167 0.0043570668 3.887357e-04 1.731190e-03 13 113637620 113637817 198 + 1.506 1.261 -0.853
ENSG00000198176 E039 504.8349707 0.0001336159 9.080511e-01 9.456324e-01 13 113637818 113637884 67 + 2.678 2.720 0.139
ENSG00000198176 E040 272.6349391 0.0002346661 8.266664e-01 8.909250e-01 13 113637885 113637896 12 + 2.414 2.448 0.115
ENSG00000198176 E041 2635.5859061 0.0029536810 1.162031e-04 5.965135e-04 13 113640120 113641473 1354 + 3.360 3.478 0.393