ENSG00000198169

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292562 ENSG00000198169 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF251 protein_coding protein_coding 6.304844 3.736618 8.85552 0.2991996 0.2245747 1.242616 4.4350651 2.7909354 6.4121282 0.21012118 0.193634113 1.1971428 0.70599167 0.7475667 0.72410000 -0.02346667 0.818804029 0.006794487 FALSE  
ENST00000525191 ENSG00000198169 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF251 protein_coding protein_coding 6.304844 3.736618 8.85552 0.2991996 0.2245747 1.242616 0.2647004 0.2936272 0.2307593 0.01774675 0.005712395 -0.3347097 0.04887083 0.0798000 0.02606667 -0.05373333 0.006794487 0.006794487 FALSE  
ENST00000530353 ENSG00000198169 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF251 protein_coding retained_intron 6.304844 3.736618 8.85552 0.2991996 0.2245747 1.242616 1.4188846 0.5869853 1.9811206 0.14528242 0.107810099 1.7378132 0.21759583 0.1535333 0.22350000 0.06996667 0.241626857 0.006794487 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198169 E001 0.6664265 0.0172671820 0.4610634112 0.601053977 8 144720907 144720908 2 - 0.158 0.294 1.149
ENSG00000198169 E002 13.9033094 0.0014145150 0.0337823336 0.079318375 8 144720909 144721022 114 - 1.069 1.277 0.743
ENSG00000198169 E003 333.0650459 0.0049546646 0.0554926972 0.118829051 8 144721023 144722798 1776 - 2.478 2.547 0.227
ENSG00000198169 E004 52.0796513 0.0004922050 0.0111794228 0.031594065 8 144722799 144722980 182 - 1.739 1.625 -0.384
ENSG00000198169 E005 67.7547682 0.0003911569 0.0005417210 0.002316123 8 144722981 144723382 402 - 1.861 1.723 -0.468
ENSG00000198169 E006 7.9993689 0.0022487022 0.0003489298 0.001575924 8 144753454 144753680 227 - 0.747 1.163 1.563
ENSG00000198169 E007 4.8306841 0.0034398922 0.1994419295 0.325543397 8 144753681 144753682 2 - 0.674 0.863 0.761
ENSG00000198169 E008 34.0539998 0.0038887188 0.5502689627 0.679916282 8 144753683 144753796 114 - 1.500 1.556 0.194
ENSG00000198169 E009 20.6077252 0.0010413333 0.5616741048 0.689434447 8 144754192 144754204 13 - 1.287 1.349 0.216
ENSG00000198169 E010 43.6125735 0.0050415935 0.9617909435 0.979910453 8 144754205 144754321 117 - 1.617 1.637 0.068
ENSG00000198169 E011 26.8605196 0.0061227529 0.1816644777 0.303324376 8 144754322 144754695 374 - 1.449 1.360 -0.308
ENSG00000198169 E012 44.3696785 0.0005834690 0.2306564782 0.363241100 8 144754696 144754745 50 - 1.648 1.600 -0.165
ENSG00000198169 E013 37.4044846 0.0006332133 0.6202495159 0.737491575 8 144754746 144754803 58 - 1.543 1.589 0.158
ENSG00000198169 E014 37.4777787 0.0009669144 0.0038189783 0.012633919 8 144754804 144755135 332 - 1.613 1.450 -0.559
ENSG00000198169 E015 21.2697414 0.0021814567 0.1720293215 0.290843237 8 144755136 144755404 269 - 1.359 1.266 -0.325
ENSG00000198169 E016 24.8444804 0.0008070103 0.1359564061 0.242423557 8 144755405 144756417 1013 - 1.342 1.464 0.422