ENSG00000198168

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000530199 ENSG00000198168 HEK293_OSMI2_2hA HEK293_TMG_2hB SVIP protein_coding processed_transcript 18.12342 19.99078 23.79446 1.97422 1.032782 0.2511759 1.372770 1.510636 2.042462 0.5862979 0.4508154 0.43268054 0.07007083 0.07153333 0.08480000 0.01326667 8.475355e-01 7.128001e-08   FALSE
ENST00000533774 ENSG00000198168 HEK293_OSMI2_2hA HEK293_TMG_2hB SVIP protein_coding processed_transcript 18.12342 19.99078 23.79446 1.97422 1.032782 0.2511759 3.068179 5.977675 1.606948 0.7266937 0.8050217 -1.88872240 0.18298750 0.29960000 0.06746667 -0.23213333 3.065633e-01 7.128001e-08   FALSE
MSTRG.5294.1 ENSG00000198168 HEK293_OSMI2_2hA HEK293_TMG_2hB SVIP protein_coding   18.12342 19.99078 23.79446 1.97422 1.032782 0.2511759 7.677330 9.628257 9.378624 0.7023437 1.0160895 -0.03785851 0.43858750 0.48413333 0.39316667 -0.09096667 2.621924e-01 7.128001e-08 TRUE FALSE
MSTRG.5294.3 ENSG00000198168 HEK293_OSMI2_2hA HEK293_TMG_2hB SVIP protein_coding   18.12342 19.99078 23.79446 1.97422 1.032782 0.2511759 5.208821 2.507819 9.240392 0.3901435 0.3248300 1.87733987 0.26552917 0.12653333 0.38973333 0.26320000 7.128001e-08 7.128001e-08 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198168 E001 3.8039705 0.0104151004 5.720918e-01 6.982596e-01 11 22813799 22813860 62 - 0.729 0.614 -0.484
ENSG00000198168 E002 12.0060552 0.0022437972 1.530919e-01 2.658808e-01 11 22813861 22814066 206 - 1.188 1.014 -0.627
ENSG00000198168 E003 25.5102227 0.0009047773 8.763459e-07 7.366275e-06 11 22818927 22820191 1265 - 1.564 1.165 -1.388
ENSG00000198168 E004 10.6978476 0.0016527825 6.790984e-04 2.822641e-03 11 22820192 22820336 145 - 1.210 0.809 -1.484
ENSG00000198168 E005 307.7569239 0.0056440057 2.209847e-22 1.835374e-20 11 22820337 22822746 2410 - 2.631 2.222 -1.363
ENSG00000198168 E006 77.2432557 0.0003728636 1.877368e-03 6.844651e-03 11 22822747 22822866 120 - 1.961 1.798 -0.546
ENSG00000198168 E007 284.6358482 0.0009467298 6.874760e-07 5.912487e-06 11 22822867 22823133 267 - 2.423 2.500 0.257
ENSG00000198168 E008 189.3325968 0.0002383715 6.805969e-09 8.657560e-08 11 22827207 22827244 38 - 2.231 2.340 0.363
ENSG00000198168 E009 274.1921815 0.0001881214 3.274328e-05 1.930216e-04 11 22827245 22827320 76 - 2.420 2.469 0.162
ENSG00000198168 E010 258.5552946 0.0002740205 2.526683e-04 1.186478e-03 11 22827824 22827874 51 - 2.397 2.439 0.140
ENSG00000198168 E011 0.6600969 0.1671190983 6.756971e-01 7.808896e-01 11 22827875 22827877 3 - 0.189 0.251 0.522
ENSG00000198168 E012 4.0555044 0.0045461296 7.574383e-01 8.422715e-01 11 22829257 22829294 38 - 0.706 0.722 0.068
ENSG00000198168 E013 7.1023247 0.0127587371 4.978976e-01 6.344262e-01 11 22829295 22829694 400 - 0.877 0.925 0.185
ENSG00000198168 E014 261.7265950 0.0003696574 3.266616e-04 1.487407e-03 11 22829695 22829872 178 - 2.402 2.444 0.138
ENSG00000198168 E015 0.0000000       11 22830164 22830299 136 -