ENSG00000198162

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356554 ENSG00000198162 HEK293_OSMI2_2hA HEK293_TMG_2hB MAN1A2 protein_coding protein_coding 8.646819 2.748961 14.35919 0.01676492 0.2676338 2.380782 7.0121772 1.231878 12.251990 0.1218982 0.4149704 3.303598 0.72121250 0.4486333 0.8527667 0.4041333 6.004565e-11 8.425467e-22 FALSE TRUE
ENST00000422329 ENSG00000198162 HEK293_OSMI2_2hA HEK293_TMG_2hB MAN1A2 protein_coding protein_coding 8.646819 2.748961 14.35919 0.01676492 0.2676338 2.380782 0.4691497 1.355295 0.000000 0.2139946 0.0000000 -7.093068 0.17285417 0.4921333 0.0000000 -0.4921333 8.425467e-22 8.425467e-22   FALSE
MSTRG.1897.2 ENSG00000198162 HEK293_OSMI2_2hA HEK293_TMG_2hB MAN1A2 protein_coding   8.646819 2.748961 14.35919 0.01676492 0.2676338 2.380782 0.7870630 0.000000 1.589898 0.0000000 0.1539481 7.321836 0.05791667 0.0000000 0.1111333 0.1111333 1.446357e-07 8.425467e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198162 E001 105.694347 0.0002688275 8.649869e-14 2.480611e-12 1 117367449 117367942 494 + 1.835 1.518 -1.079
ENSG00000198162 E002 70.330223 0.0003636941 1.048348e-05 6.937728e-05 1 117367943 117368073 131 + 1.652 1.503 -0.507
ENSG00000198162 E003 126.572851 0.0002691916 4.384568e-08 4.782607e-07 1 117368074 117368485 412 + 1.901 1.782 -0.399
ENSG00000198162 E004 105.328884 0.0003107101 2.185547e-07 2.079481e-06 1 117402186 117402441 256 + 1.823 1.689 -0.451
ENSG00000198162 E005 69.695568 0.0003621915 2.765776e-04 1.284386e-03 1 117405549 117405645 97 + 1.642 1.558 -0.288
ENSG00000198162 E006 75.480519 0.0004238958 1.118084e-05 7.346110e-05 1 117414713 117414831 119 + 1.680 1.545 -0.460
ENSG00000198162 E007 48.491622 0.0011075695 1.605805e-02 4.286588e-02 1 117420569 117420596 28 + 1.485 1.457 -0.095
ENSG00000198162 E008 57.471400 0.0015696380 2.170213e-03 7.750786e-03 1 117420597 117420649 53 + 1.559 1.489 -0.241
ENSG00000198162 E009 57.288146 0.0004443325 4.833933e-04 2.096553e-03 1 117442231 117442325 95 + 1.560 1.458 -0.352
ENSG00000198162 E010 64.574521 0.0004024331 1.404999e-07 1.387907e-06 1 117460489 117460612 124 + 1.622 1.368 -0.871
ENSG00000198162 E011 55.463105 0.0004126934 1.181614e-04 6.053848e-04 1 117466334 117466427 94 + 1.549 1.406 -0.491
ENSG00000198162 E012 70.935414 0.0003645741 4.066760e-06 2.952426e-05 1 117493147 117493262 116 + 1.655 1.489 -0.567
ENSG00000198162 E013 39.434084 0.0005281372 1.893176e-03 6.892965e-03 1 117496763 117496779 17 + 1.406 1.281 -0.436
ENSG00000198162 E014 82.146528 0.0003235685 4.813904e-05 2.723710e-04 1 117496780 117496982 203 + 1.711 1.618 -0.318
ENSG00000198162 E015 68.308765 0.0004027397 6.887011e-02 1.414968e-01 1 117499382 117499554 173 + 1.619 1.670 0.174
ENSG00000198162 E016 29.655406 0.0006904884 1.838588e-01 3.060630e-01 1 117502855 117502860 6 + 1.270 1.305 0.122
ENSG00000198162 E017 58.100137 0.0004268005 2.136166e-01 3.428010e-01 1 117502861 117502970 110 + 1.546 1.629 0.283
ENSG00000198162 E018 2.217592 0.2051327375 2.093781e-01 3.377987e-01 1 117514849 117515939 1091 + 0.278 0.738 2.319
ENSG00000198162 E019 66.660981 0.0038962442 2.923321e-01 4.332938e-01 1 117522825 117522937 113 + 1.604 1.699 0.324
ENSG00000198162 E020 104.281358 0.0045783435 1.050523e-01 1.981643e-01 1 117522938 117523249 312 + 1.796 1.868 0.241
ENSG00000198162 E021 292.165974 0.0031754262 8.148360e-01 8.826792e-01 1 117523250 117525088 1839 + 2.225 2.408 0.610
ENSG00000198162 E022 654.715291 0.0111359634 1.598296e-19 9.667702e-18 1 117525089 117528872 3784 + 2.512 3.012 1.664