ENSG00000198157

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358130 ENSG00000198157 HEK293_OSMI2_2hA HEK293_TMG_2hB HMGN5 protein_coding protein_coding 56.18437 29.41829 86.89361 1.916954 5.337221 1.562212 10.301025 9.984538 13.19334 0.3626686 0.6256636 0.4016916 0.2143042 0.34066667 0.1526333 -0.188033333 3.850957e-14 3.850957e-14 FALSE TRUE
ENST00000373250 ENSG00000198157 HEK293_OSMI2_2hA HEK293_TMG_2hB HMGN5 protein_coding protein_coding 56.18437 29.41829 86.89361 1.916954 5.337221 1.562212 7.184928 2.332608 11.63504 0.5343288 1.9144526 2.3135278 0.1201375 0.07783333 0.1322333 0.054400000 9.624704e-02 3.850957e-14 FALSE FALSE
ENST00000430960 ENSG00000198157 HEK293_OSMI2_2hA HEK293_TMG_2hB HMGN5 protein_coding protein_coding 56.18437 29.41829 86.89361 1.916954 5.337221 1.562212 31.014215 15.184439 45.25982 1.2691589 1.2658708 1.5750062 0.5438750 0.51503333 0.5240000 0.008966667 9.516507e-01 3.850957e-14 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198157 E001 313.4486380 0.0028479424 2.724818e-48 1.518261e-45 X 81113699 81114641 943 - 2.261 2.717 1.520
ENSG00000198157 E002 93.1186373 0.0003425848 5.633262e-09 7.285170e-08 X 81114642 81114661 20 - 1.860 2.086 0.758
ENSG00000198157 E003 78.7090122 0.0003364604 5.138039e-04 2.210935e-03 X 81114662 81114662 1 - 1.821 1.971 0.505
ENSG00000198157 E004 93.6125073 0.0002757570 2.493551e-03 8.744890e-03 X 81114663 81114669 7 - 1.907 2.029 0.409
ENSG00000198157 E005 141.3303378 0.0002234256 5.627204e-03 1.762369e-02 X 81114670 81114725 56 - 2.096 2.189 0.312
ENSG00000198157 E006 188.6730107 0.0027448874 2.862372e-01 4.266365e-01 X 81114726 81114834 109 - 2.266 2.235 -0.104
ENSG00000198157 E007 195.3694933 0.0066546911 2.195145e-04 1.047515e-03 X 81114835 81114984 150 - 2.321 2.155 -0.552
ENSG00000198157 E008 150.9255504 0.0102082435 2.386864e-07 2.254046e-06 X 81114985 81115053 69 - 2.240 1.945 -0.990
ENSG00000198157 E009 167.3233698 0.0010411590 2.109484e-17 9.869980e-16 X 81115054 81115110 57 - 2.284 1.995 -0.966
ENSG00000198157 E010 234.2975064 0.0001974585 3.346744e-08 3.735304e-07 X 81115111 81115191 81 - 2.390 2.258 -0.441
ENSG00000198157 E011 205.4127532 0.0001937681 4.287405e-03 1.394732e-02 X 81115192 81115230 39 - 2.314 2.246 -0.227
ENSG00000198157 E012 422.9685784 0.0003187712 4.253683e-01 5.683147e-01 X 81116204 81116341 138 - 2.607 2.600 -0.021
ENSG00000198157 E013 308.0682942 0.0007657876 4.405198e-01 5.821979e-01 X 81118432 81118485 54 - 2.470 2.460 -0.032
ENSG00000198157 E014 18.6514663 0.0072382928 7.211307e-01 8.155987e-01 X 81118486 81118488 3 - 1.278 1.252 -0.093
ENSG00000198157 E015 232.0824782 0.0003022237 1.393861e-01 2.472036e-01 X 81118730 81118759 30 - 2.353 2.324 -0.097
ENSG00000198157 E016 7.0850422 0.0211527499 3.906756e-01 5.346436e-01 X 81118760 81118780 21 - 0.929 0.808 -0.462
ENSG00000198157 E017 199.1075975 0.0004211551 5.531958e-02 1.185454e-01 X 81119788 81119817 30 - 2.291 2.246 -0.150
ENSG00000198157 E018 264.6262306 0.0008260899 1.507628e-01 2.627196e-01 X 81121535 81121672 138 - 2.409 2.380 -0.096
ENSG00000198157 E019 4.3918646 0.0041257056 1.990265e-07 1.907664e-06 X 81121673 81121688 16 - 0.316 1.056 3.280
ENSG00000198157 E020 3.1504464 0.0050308327 8.603484e-02 1.690456e-01 X 81195118 81195297 180 - 0.686 0.395 -1.375
ENSG00000198157 E021 0.4804688 0.0224291368 9.194398e-01 9.531177e-01 X 81197706 81197778 73 - 0.155 0.175 0.211
ENSG00000198157 E022 3.7214690 0.0042595458 8.838401e-01 9.297260e-01 X 81201737 81201939 203 - 0.666 0.650 -0.070