ENSG00000198081

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000400143 ENSG00000198081 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB14 protein_coding protein_coding 4.405127 1.942408 7.18625 0.151912 0.3121541 1.881991 1.1696731 0.1847664 2.0226251 0.07077382 0.09325726 3.383527 0.2199167 0.10253333 0.2814667 0.1789333 0.0168910 0.016891 FALSE TRUE
ENST00000585253 ENSG00000198081 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB14 protein_coding retained_intron 4.405127 1.942408 7.18625 0.151912 0.3121541 1.881991 0.4782292 0.1449917 0.9318381 0.07713578 0.22005397 2.603288 0.1104333 0.06973333 0.1275333 0.0578000 0.5298484 0.016891   FALSE
ENST00000614697 ENSG00000198081 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB14 protein_coding protein_coding 4.405127 1.942408 7.18625 0.151912 0.3121541 1.881991 2.5761149 1.5334043 3.9227711 0.23615121 0.30305855 1.349430 0.6261958 0.77953333 0.5455667 -0.2339667 0.0347645 0.016891 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198081 E001 0.0000000       18 5289019 5289019 1 -      
ENSG00000198081 E002 0.0000000       18 5289020 5289021 2 -      
ENSG00000198081 E003 134.8727872 0.0003842362 5.670266e-13 1.446754e-11 18 5289022 5290857 1836 - 2.031 2.220 0.635
ENSG00000198081 E004 108.4989477 0.0003036387 7.796760e-02 1.562147e-01 18 5290858 5291544 687 - 2.016 1.958 -0.193
ENSG00000198081 E005 38.7228894 0.0007480631 7.296017e-01 8.217609e-01 18 5291545 5291711 167 - 1.564 1.545 -0.068
ENSG00000198081 E006 33.9341742 0.0006471326 3.112040e-02 7.413787e-02 18 5291712 5291900 189 - 1.541 1.398 -0.494
ENSG00000198081 E007 28.6536616 0.0007502834 1.853305e-03 6.768513e-03 18 5291901 5292077 177 - 1.486 1.249 -0.822
ENSG00000198081 E008 20.8669187 0.0009638184 9.608390e-04 3.824681e-03 18 5292078 5292204 127 - 1.366 1.065 -1.066
ENSG00000198081 E009 14.5012294 0.0013421039 8.899391e-02 1.735923e-01 18 5293244 5293327 84 - 1.194 1.021 -0.623
ENSG00000198081 E010 4.3445712 0.0253310638 3.855205e-01 5.297163e-01 18 5293328 5293647 320 - 0.730 0.579 -0.646
ENSG00000198081 E011 3.2202479 0.0624850831 9.899271e-01 9.978118e-01 18 5293972 5294001 30 - 0.585 0.582 -0.016
ENSG00000198081 E012 0.8783093 0.0467829770 6.224892e-01 7.392723e-01 18 5294801 5294824 24 - 0.290 0.192 -0.769
ENSG00000198081 E013 0.2903454 0.3299407873 8.374752e-01   18 5295652 5295812 161 - 0.139 0.000 -8.691
ENSG00000198081 E014 8.0812410 0.0467259554 5.972946e-01 7.190833e-01 18 5295813 5296195 383 - 0.944 0.855 -0.336
ENSG00000198081 E015 0.0000000       18 5297012 5297053 42 -